Barium
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Basic Info
Common Name | Barium(F03354) |
2D Structure | |
Description | Barium is a dense alkaline earth metal that occurs in nature as a divalent cation in combination with other elements. Physiologically, it exists as an ion in the body. In addition to its natural presence in the Earth's crust, and therefore its natural occurrence in most surface waters, barium is also released to the environment via industrial emissions. The residence time of barium in the atmosphere may be up to several days. Barium sulfate exists as a white orthorhombic powder or crystals. Barite, the mineral from which barium sulfate is produced, is a moderately soft crystalline white opaque to transparent mineral. The most important impurities are iron(III) oxide, aluminium oxide, silica, and strontium sulfate.Barium sulfate has a low toxicity and relatively high density of about 4.5 g*cm-3 (and thus opacity to X-rays). For this reason it is used as a radiocontrast agent in X-ray imaging of the digestive system (barium meals and barium enemas). Lithopone, a pigment that contains barium sulfate and zinc sulfide, is a permanent white that has good covering power, and does not darken when exposed to sulfides. (Wikipedia). Barium hydroxide is strongly alkaline and therefore corrosive. Barium nitrate caused mild skin irritation and severe eye irritation in rabbits. The lack of reports of skin or eye irritation in humans, despite its widespread use, suggests that barium sulfate, often used as a contrast medium, is not a strong irritant. Useful information on the sensitization potential of barium compounds was not identified. Oral intake from drinking water and food is the most prevalent route of exposure to barium compounds for the general population. For the occupational environment, data from industry in the United Kingdom and predictions made using the Estimation and Assessment of Substance Exposure (EASE) model suggest that exposures can be controlled to less than 10 mg/m3 8 hours time weighted average (total inhalable dust). In some situations, control will be to levels significantly below this value. Short term exposures may be higher than 10 mg/m3 for some tasks.The critical end points in humans for toxicity resulting from exposure to barium and barium compounds appear to be hypertension and renal function. Using a no observed adverse effect level (NOAEL) in humans of 0.21 mg barium/kg body weight per day, a tolerable intake value of 0.02 mg/kg body weight per day for barium and barium compounds has been developed in this document.Dissolved barium in aquatic environments may represent a risk to aquatic organisms such as daphnids, but it is apparently of lesser risk to fish and aquatic plants, although data are limited. No adverse effects have been reported in ecological assessments of terrestrial plants or wildlife, although some plants are known to bioaccumulate barium from the soil.(Concise international chemical assessment document 33; http://www.inchem.org/documents/cicads/cicads/cicad33.htm). |
FRCD ID | F03354 |
CAS Number | 7440-39-3 |
PubChem CID | 104810 |
Formula | Ba+2 |
IUPAC Name | barium(2+) |
InChI Key | XDFCIPNJCBUZJN-UHFFFAOYSA-N |
InChI | InChI=1S/Ba/q+2 |
Canonical SMILES | [Ba+2] |
Isomeric SMILES | [Ba+2] |
Wikipedia | Barium |
Synonyms | barium(II) cation barium(2+) BARIUM ION barium cation Ba2+ Barium (II) ion UNII-V645272HLN Ba(2+) V645272HLN 22541-12-4 |
Classifies | Metal |
Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
Kingdom | Inorganic compounds |
Superclass | Homogeneous metal compounds |
Class | Homogeneous alkaline earth metal compounds |
Subclass | Not available |
Intermediate Tree Nodes | Not available |
Direct Parent | Homogeneous alkaline earth metal compounds |
Alternative Parents | |
Molecular Framework | Not available |
Substituents | Homogeneous alkaline earth metal |
Description | This compound belongs to the class of inorganic compounds known as homogeneous alkaline earth metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkaline earth metal atom. |
Properties
Property Name | Property Value |
---|---|
Molecular Weight | 137.327 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 0 |
Rotatable Bond Count | 0 |
Complexity | 0 |
Monoisotopic Mass | 137.905 |
Exact Mass | 137.905 |
Formal Charge | 2 |
Heavy Atom Count | 1 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Isotope Atom Count | 0 |
Covalently-Bonded Unit Count | 1 |
References
Title | Journal | Date | Pubmed ID |
---|---|---|---|
High-density element concentrations in fish from subtidal to hadal zones of the Pacific Ocean. | Heliyon | 2018 Oct | 30320235 |
Bioaccessibility assessment of toxic and essential elements in produced pulses, Bahia, Brazil. | Food Chem | 2018 Feb 1 | 28946232 |
A Limited Survey of Metal Content in Blue Jack Mackerel ( Trachurus picturatus) Obtained from Markets in the Canary Islands. | J Food Prot | 2018 Feb | 29320235 |
An Adult Zebrafish Diet Contaminated with Chromium Reduces the Viability of Progeny. | Zebrafish | 2018 Apr | 29293412 |
Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines. | Environ Mol Mutagen | 2018 Apr | 29150881 |
β-galactosidase from Aspergillus lacticoffeatus: A promising biocatalyst for the synthesis of novel prebiotics. | Int J Food Microbiol | 2017 Sep 18 | 28646668 |
Divalent Cations Regulate the Ion Conductance Properties of Diverse Classes ofAquaporins. | Int J Mol Sci | 2017 Nov 3 | 29099773 |
Comparison of trace elements in size-fractionated particles in two communities with contrasting socioeconomic status in Houston, TX. | Environ Monit Assess | 2017 Feb | 28110452 |
Interfacing DNA Oligonucleotides with Calcium Phosphate and Other MetalPhosphates. | Langmuir | 2017 Dec 27 | 29228772 |
Spatial distribution of trace element Ca-normalized ratios in primary and permanent human tooth enamel. | Sci Total Environ | 2017 Dec 15 | 28628822 |
Desulfurization: Critical step towards enhanced selenium removal from industrial effluents. | Chemosphere | 2017 Apr | 28063313 |
POEM and the management of achalasia. | Frontline Gastroenterol | 2017 Apr | 28839899 |
Selenium deficiency-induced alterations in ion profiles in chicken muscle. | PLoS One | 2017 | 28877212 |
Interactions of Nanosized Aggregates of Fullerene C60 with Electrolytes inMethanol: Coagulation and Overcharging of Particles. | Langmuir | 2016 Oct 4 | 27610710 |
Endoscopic treatment of esophageal achalasia. | World J Gastrointest Endosc | 2016 Jan 25 | 26839644 |
Evaluated the Twenty-Six Elements in the Pectoral Muscle of As-Treated Chicken by Inductively Coupled Plasma Mass Spectrometry. | Biol Trace Elem Res | 2016 Feb | 26123164 |
Barium chloride induces redox status unbalance, upregulates cytokine genes expression and confers hepatotoxicity in rats-alleviation by pomegranate peel. | Environ Sci Pollut Res Int | 2016 Apr | 26732703 |
Essential and toxic elements in meat of wild birds. | J Toxicol Environ Health A | 2016 | 27599146 |
Clinical management of achalasia: current state of the art. | Clin Exp Gastroenterol | 2016 | 27110134 |
Expression and Biochemical Characterization of a Thermostable Branching Enzymefrom Geobacillus thermoglucosidans. | J Mol Microbiol Biotechnol | 2016 | 27416069 |
Targets
- Uniprot ID:
- P48048; P78508; Q14654; Q14500; Q9UNX9; Q99712; Q15842
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- Uniprot ID:
- P62158
- Mechanism of Action:
- Barium is believed to bind and activate calmodulin, causing certain neurotoxic effects.
References
- Kursula P, Majava V: A structural insight into lead neurotoxicity and calmodulin activation by heavy metals. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):653-6. Epub 2007 Jul 28. [17671360 ]
- General Function:
- Voltage-gated potassium channel activity
- Specific Function:
- This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
- Gene Name:
- KCNJ11
- Uniprot ID:
- Q14654
- Molecular Weight:
- 43540.375 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Inward rectifier potassium channel activity
- Specific Function:
- Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
- Gene Name:
- KCNJ12
- Uniprot ID:
- Q14500
- Molecular Weight:
- 49000.6 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Inward rectifier potassium channel activity
- Specific Function:
- This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).
- Gene Name:
- KCNJ8
- Uniprot ID:
- Q15842
- Molecular Weight:
- 47967.455 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Inward rectifier potassium channel activity
- Specific Function:
- This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
- Gene Name:
- KCNJ6
- Uniprot ID:
- P48051
- Molecular Weight:
- 48450.96 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- G-protein activated inward rectifier potassium channel activity
- Specific Function:
- This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).
- Gene Name:
- KCNJ9
- Uniprot ID:
- Q92806
- Molecular Weight:
- 44019.45 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- G-protein activated inward rectifier potassium channel activity
- Specific Function:
- This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
- Gene Name:
- KCNJ5
- Uniprot ID:
- P48544
- Molecular Weight:
- 47667.3 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Inward rectifier potassium channel activity
- Specific Function:
- Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
- Gene Name:
- KCNJ13
- Uniprot ID:
- O60928
- Molecular Weight:
- 40529.195 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Inward rectifier potassium channel activity
- Specific Function:
- Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.
- Gene Name:
- KCNJ16
- Uniprot ID:
- Q9NPI9
- Molecular Weight:
- 47948.585 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Pdz domain binding
- Specific Function:
- Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
- Gene Name:
- KCNJ4
- Uniprot ID:
- P48050
- Molecular Weight:
- 49499.61 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Voltage-gated potassium channel activity
- Specific Function:
- Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
- Gene Name:
- KCNH3
- Uniprot ID:
- Q9ULD8
- Molecular Weight:
- 117127.74 Da
References
- Becchetti A, De Fusco M, Crociani O, Cherubini A, Restano-Cassulini R, Lecchi M, Masi A, Arcangeli A, Casari G, Wanke E: The functional properties of the human ether-a-go-go-like (HELK2) K+ channel. Eur J Neurosci. 2002 Aug;16(3):415-28. [12193184 ]
- General Function:
- Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
- Specific Function:
- Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed:10713961). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed:10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms an heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). When associated with KCNE4, inhibits voltage-gated potassium channel activity (PubMed:19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed:12324418). Also forms an heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (PubMed:24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed:25037568).Isoform 2: Non-functional alone but modulatory when coexpressed with the full-length isoform 1.
- Gene Name:
- KCNQ1
- Uniprot ID:
- P51787
- Molecular Weight:
- 74697.925 Da
- Mechanism of Action:
- Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [15226366 ]
- General Function:
- Voltage-gated potassium channel activity
- Specific Function:
- Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
- Gene Name:
- KCNQ2
- Uniprot ID:
- O43526
- Molecular Weight:
- 95846.575 Da
- Mechanism of Action:
- Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [15226366 ]
- General Function:
- Voltage-gated potassium channel activity
- Specific Function:
- Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
- Gene Name:
- KCNQ3
- Uniprot ID:
- O43525
- Molecular Weight:
- 96741.515 Da
- Mechanism of Action:
- Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [15226366 ]
- General Function:
- Potassium channel activity
- Specific Function:
- Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
- Gene Name:
- KCNQ4
- Uniprot ID:
- P56696
- Molecular Weight:
- 77099.99 Da
- Mechanism of Action:
- Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [15226366 ]
- General Function:
- Phosphatidylinositol-4,5-bisphosphate binding
- Specific Function:
- In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
- Gene Name:
- KCNJ1
- Uniprot ID:
- P48048
- Molecular Weight:
- 44794.6 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- G-protein activated inward rectifier potassium channel activity
- Specific Function:
- This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
- Gene Name:
- KCNJ3
- Uniprot ID:
- P48549
- Molecular Weight:
- 56602.84 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
- Specific Function:
- Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
- Gene Name:
- KCNJ2
- Uniprot ID:
- P63252
- Molecular Weight:
- 48287.82 Da
- Mechanism of Action:
- Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [11454958 ]
- General Function:
- Voltage-gated potassium channel activity
- Specific Function:
- Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
- Gene Name:
- KCNQ5
- Uniprot ID:
- Q9NR82
- Molecular Weight:
- 102178.015 Da
- Mechanism of Action:
- Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis.
References
- Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [15226366 ]