Palladium
(right click,save link as to download,it is a temp file,please download as soon as possible, you can also use CTRL+S to save the whole html page)
Basic Info
| Common Name | Palladium(F03412) |
| 2D Structure | |
| Description | Palladium is a rare and lustrous silvery-white metal. Palladium has the lowest melting point and is the least dense of platinum group metals. The primary use for palladium is in catalytic converters for the automotive industry. |
| FRCD ID | F03412 |
| CAS Number | 7440-05-03 |
| PubChem CID | 23938 |
| Formula | Pd |
| IUPAC Name | palladium |
| InChI Key | KDLHZDBZIXYQEI-UHFFFAOYSA-N |
| InChI | InChI=1S/Pd |
| Canonical SMILES | [Pd] |
| Isomeric SMILES | [Pd] |
| Wikipedia | Palladium |
| Synonyms |
Palladium on carbon
Palladium
7440-05-3
Palladium Black
paladio
PD
palladium/carbon
Palladium element
palladium charcoal
Palladium, element
|
| Classifies |
Metal
|
| Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
| Kingdom | Inorganic compounds |
| Superclass | Homogeneous metal compounds |
| Class | Homogeneous transition metal compounds |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Homogeneous transition metal compounds |
| Alternative Parents | |
| Molecular Framework | Not available |
| Substituents | Homogeneous transition metal |
| Description | This compound belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom. |
Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 106.42 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Complexity | 0 |
| Monoisotopic Mass | 105.903 |
| Exact Mass | 105.903 |
| Formal Charge | 0 |
| Heavy Atom Count | 1 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 1 |
ADMET
| Model | Result | Probability |
|---|---|---|
| Absorption | ||
| Blood-Brain Barrier | BBB+ | 0.9733 |
| Human Intestinal Absorption | HIA+ | 0.9838 |
| Caco-2 Permeability | Caco2+ | 0.7354 |
| P-glycoprotein Substrate | Non-substrate | 0.8850 |
| P-glycoprotein Inhibitor | Non-inhibitor | 0.9787 |
| Non-inhibitor | 0.9858 | |
| Renal Organic Cation Transporter | Non-inhibitor | 0.9108 |
| Distribution | ||
| Subcellular localization | Lysosome | 0.5856 |
| Metabolism | ||
| CYP450 2C9 Substrate | Non-substrate | 0.8466 |
| CYP450 2D6 Substrate | Non-substrate | 0.8259 |
| CYP450 3A4 Substrate | Non-substrate | 0.8158 |
| CYP450 1A2 Inhibitor | Non-inhibitor | 0.8807 |
| CYP450 2C9 Inhibitor | Non-inhibitor | 0.9373 |
| CYP450 2D6 Inhibitor | Non-inhibitor | 0.9708 |
| CYP450 2C19 Inhibitor | Non-inhibitor | 0.9553 |
| CYP450 3A4 Inhibitor | Non-inhibitor | 0.9880 |
| CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.8820 |
| Excretion | ||
| Toxicity | ||
| Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9547 |
| Non-inhibitor | 0.9746 | |
| AMES Toxicity | Non AMES toxic | 0.9633 |
| Carcinogens | Carcinogens | 0.6640 |
| Fish Toxicity | Low FHMT | 0.6181 |
| Tetrahymena Pyriformis Toxicity | Low TPT | 0.6631 |
| Honey Bee Toxicity | High HBT | 0.8314 |
| Biodegradation | Ready biodegradable | 0.7326 |
| Acute Oral Toxicity | III | 0.5846 |
| Carcinogenicity (Three-class) | Warning | 0.4769 |
| Model | Value | Unit |
|---|---|---|
| Absorption | ||
| Aqueous solubility | -1.0958 | LogS |
| Caco-2 Permeability | 1.6017 | LogPapp, cm/s |
| Distribution | ||
| Metabolism | ||
| Excretion | ||
| Toxicity | ||
| Rat Acute Toxicity | 2.0135 | LD50, mol/kg |
| Fish Toxicity | 1.5413 | pLC50, mg/L |
| Tetrahymena Pyriformis Toxicity | -0.7156 | pIGC50, ug/L |
References
| Title | Journal | Date | Pubmed ID |
|---|---|---|---|
| An ITO-based point-of-care colorimetric immunosensor for ochratoxin A detection. | Talanta | 2018 Oct 1 | 30029418 |
| Discrimination of infectious and heat-treated norovirus by combining platinumcompounds and real-time RT-PCR. | Int J Food Microbiol | 2018 Mar 23 | 29421360 |
| Palladium nanoparticle-decorated reduced graphene oxide sheets synthesized using Ficus carica fruit extract: A catalyst for Suzuki cross-coupling reactions. | PLoS One | 2018 Feb 21 | 29466453 |
| Are sainfoin or protein supplements alternatives to control small strongyleinfection in horses? | Animal | 2018 Feb | 28535838 |
| Palladium-Catalyzed Cross-Coupling Reactions: A Powerful Tool for the Synthesisof Agrochemicals. | J Agric Food Chem | 2018 Aug 13 | 30060657 |
| Effects of noble metal nanoparticles on the hydroxyl radical scavenging abilityof dietary antioxidants. | J Environ Sci Health C Environ Carcinog Ecotoxicol Rev | 2018 Apr 3 | 29667503 |
| Palladium Nanoparticles Immobilized on Individual Calcium Carbonate PlatesDerived from Mussel Shell Waste: An Ecofriendly Catalyst for the Copper-FreeSonogashira Coupling Reaction. | Chem Asian J | 2017 Sep 5 | 28544781 |
| Controlling the Deposition of Pd on Au Nanocages: Outer Surface Only versus Both Outer and Inner Surfaces. | Nano Lett | 2017 Sep 13 | 28777579 |
| Biomonitoring of 29 trace elements in whole blood from inhabitants of Cotonou(Benin) by ICP-MS. | J Trace Elem Med Biol | 2017 Sep | 27847219 |
| Multi-elemental analysis of human lung samples using inductively coupled plasmamass spectrometry. | J Trace Elem Med Biol | 2017 Sep | 27890402 |
| Palladium Nanoparticles-Based Fluorescence Resonance Energy Transfer Aptasensor for Highly Sensitive Detection of Aflatoxin M₁ in Milk. | Toxins (Basel) | 2017 Oct 13 | 29027938 |
| Characterization and origin of organic and inorganic pollution in urban soils in Pisa (Tuscany, Italy). | Environ Monit Assess | 2017 Oct 12 | 29027050 |
| Partial Hydrogenation of Sunflower Oil-derived FAMEs Catalyzed by the Efficientand Recyclable Palladium Nanoparticles in Polyethylene Glycol. | J Oleo Sci | 2017 Oct 1 | 28924078 |
| Transition Metal (II) Complexes with a Novel Azo-azomethine Schiff Base Ligand:Synthesis, Structural and Spectroscopic Characterization, Thermal Properties and Biological Applications. | J Fluoresc | 2017 Nov | 28840399 |
| Bacterial effects and interfacial inactivation mechanism of nZVI/Pd on Pseudomonas putida strain. | Water Res | 2017 May 15 | 28285239 |
| Electrochemical simulation of biotransformation reactions of citrinin and dihydroergocristine compared to UV irradiation and Fenton-like reaction. | Anal Bioanal Chem | 2017 Jun | 28424858 |
| Analysis of the effect of temperature and reaction time on yields, compositionsand oil quality in catalytic and non-catalytic lignin solvolysis in a formicacid/water media using experimental design. | Bioresour Technol | 2017 Jun | 28319777 |
| Formation of iron oxide/Pd hybrid nanostructures with enhanced peroxidase-likeactivity and catalytic reduction of 4-nitrophenol. | J Environ Sci Health C Environ Carcinog Ecotoxicol Rev | 2017 Jul 3 | 28532274 |
| Activated-Lignite-Based Super Large Granular Slow-Release Fertilizers ImproveApple Tree Growth: Synthesis, Characterizations, and Laboratory and FieldEvaluations. | J Agric Food Chem | 2017 Jul 26 | 28671837 |
| Selectivity Control in the Tandem Aromatization of Bio-Based Furanics Catalyzedby Solid Acids and Palladium. | ChemSusChem | 2017 Jan 10 | 27557889 |
Targets
- General Function:
- Creatine kinase activity
- Specific Function:
- Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- Gene Name:
- CKM
- Uniprot ID:
- P06732
- Molecular Weight:
- 43100.91 Da
- Mechanism of Action:
- Palladium inhibits creatine kinase by forming a complex with its essential SH groups.
References
- Liu TZ, Khayam-Bashi H, Bhatnagar RS: Inhibition of creatine kinase activity and alterations in electrophoretic mobility by palladium ions. J Environ Pathol Toxicol. 1979 Jan-Feb;2(3):907-16. [422942 ]
- General Function:
- Procollagen-proline 4-dioxygenase activity
- Specific Function:
- Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
- Gene Name:
- P4HA1
- Uniprot ID:
- P13674
- Molecular Weight:
- 61048.775 Da
- Mechanism of Action:
- Palladium irreversibly inhibits prolyl hydroxylase by replacing Fe2+ in the active site, forming a strong complex with the enzyme.
References
- Rapaka RS, Sorensen KR, Lee SD, Bhatnagar RS: Inhibition of hydroxyproline synthesis by palladium ions. Biochim Biophys Acta. 1976 Mar 11;429(1):63-71. [177068 ]
- General Function:
- Procollagen-proline 4-dioxygenase activity
- Specific Function:
- Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
- Gene Name:
- P4HA2
- Uniprot ID:
- O15460
- Molecular Weight:
- 60901.42 Da
- Mechanism of Action:
- Palladium irreversibly inhibits prolyl hydroxylase by replacing Fe2+ in the active site, forming a strong complex with the enzyme.
References
- Rapaka RS, Sorensen KR, Lee SD, Bhatnagar RS: Inhibition of hydroxyproline synthesis by palladium ions. Biochim Biophys Acta. 1976 Mar 11;429(1):63-71. [177068 ]
- General Function:
- Procollagen-proline 4-dioxygenase activity
- Specific Function:
- Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
- Gene Name:
- P4HA3
- Uniprot ID:
- Q7Z4N8
- Molecular Weight:
- 61125.675 Da
- Mechanism of Action:
- Palladium irreversibly inhibits prolyl hydroxylase by replacing Fe2+ in the active site, forming a strong complex with the enzyme.
References
- Rapaka RS, Sorensen KR, Lee SD, Bhatnagar RS: Inhibition of hydroxyproline synthesis by palladium ions. Biochim Biophys Acta. 1976 Mar 11;429(1):63-71. [177068 ]
- General Function:
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
- Specific Function:
- Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
- Gene Name:
- P4HTM
- Uniprot ID:
- Q9NXG6
- Molecular Weight:
- 56660.535 Da
- Mechanism of Action:
- Palladium irreversibly inhibits prolyl hydroxylase by replacing Fe2+ in the active site, forming a strong complex with the enzyme.
References
- Rapaka RS, Sorensen KR, Lee SD, Bhatnagar RS: Inhibition of hydroxyproline synthesis by palladium ions. Biochim Biophys Acta. 1976 Mar 11;429(1):63-71. [177068 ]