Fluorine
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Basic Info
Common Name | Fluorine(F03428) |
2D Structure | |
Description | Fluorine (Latin: fluere, meaning to flow), is the chemical element with the symbol F and atomic number 9. It is a nonmetallic, diatomic gas that is a trace element and member of the halogen family. Pure fluorine (F2) is a corrosive, poisonous, pale yellowish brown gas that is a powerful oxidizing agent. It is the most reactive and electronegative of all the elements (4.0), and readily forms compounds with most other elements. Fluorine even combines with the noble gases, krypton, xenon, and radon. Even in dark, cool conditions, fluorine reacts explosively with hydrogen. It is so reactive that glass, metals, and even water, as well as other substances, burn with a bright flame in a jet of fluorine gas. It is far too reactive to be found in elemental form and has such an affinity for most elements, including silicon, that it can neither be prepared nor be kept in ordinary glass vessels. Instead, it must be kept in specialized quartz tubes lined with a very thin layer of fluorocarbons. In moist air it reacts with water to form also-dangerous hydrofluoric acid. Elemental fluorine is a powerful oxidizer which can cause organic material, combustibles, or other flammable materials to ignite. Both elemental fluorine and fluoride ions are highly toxic and must be handled with great care and any contact with skin and eyes should be strictly avoided. Physiologically, fluorine. exists as an ion in the body. When it is a free element, fluorine has a characteristic pungent odor that is detectable in concentrations as low as 20 nL/L. Fluorine is used in dentistry as flouride (Fluorides) to prevent dental caries. Sodium and stannous salts of fluorine are commonly used in dentifrices. Contact of exposed skin with HF (hydrofluoric acid) solutions posses one of the most extreme and insidious industrial threats-- one which is exacerbated by the fact that HF damages nerves in such a way as to make such burns initially painless. The HF molecule is capable of rapidly migrating through lipid layers of cells which would ordinarily stop an ionized acid, and the burns are typically deep. HF may react with calcium, permanently damaging the bone. More seriously, reaction with the body's calcium can cause cardiac arrhythmias, followed by cardiac arrest brought on by sudden chemical changes within the body. These cannot always be prevented with local or intravenous injection of calcium salts. HF spills over just 2.5% of the body's surface area, despite copious immediate washing, have been fatal If the patient survives, HF burns typically produce open wounds of an especially slow-healing nature. Fluorine in the form of fluorspar (also called fluorite) (calcium fluoride) was described in 1530 by Georgius Agricola for its use as a flux , which is a substance that is used to promote the fusion of metals or minerals. In 1670 Schwanhard found that glass was etched when it was exposed to fluorspar that was treated with acid. Karl Scheele and many later researchers, including Humphry Davy, Gay-Lussac, Antoine Lavoisier, and Louis Thenard all would experiment with hydrofluoric acid, easily obtained by treating calcium fluoride (fluorspar) with concentrated sulfuric acid. |
FRCD ID | F03428 |
CAS Number | 7782-41-4 |
PubChem CID | 28179 |
Formula | F- |
IUPAC Name | fluoride |
InChI Key | KRHYYFGTRYWZRS-UHFFFAOYSA-M |
InChI | InChI=1S/FH/h1H/p-1 |
Canonical SMILES | [F-] |
Isomeric SMILES | [F-] |
Wikipedia | Fluorine |
Synonyms | fluoride ion Fluoride ion(F-) fluoride Fluoride(1-) Fluoride ion(1-) 16984-48-8 Perfluoride Fluoride dust Fluorine ion Fluorine ion(1-) |
Classifies | Predicted: Pollutant |
Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
Kingdom | Inorganic compounds |
Superclass | Homogeneous non-metal compounds |
Class | Homogeneous halogens |
Subclass | Not available |
Intermediate Tree Nodes | Not available |
Direct Parent | Homogeneous halogens |
Alternative Parents | |
Molecular Framework | Not available |
Substituents | Homogeneous halogen |
Description | This compound belongs to the class of inorganic compounds known as homogeneous halogens. These are inorganic non-metallic compounds in which the largest atom is a nobel gas. |
Properties
Property Name | Property Value |
---|---|
Molecular Weight | 18.998 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 1 |
Rotatable Bond Count | 0 |
Complexity | 0 |
Monoisotopic Mass | 18.998 |
Exact Mass | 18.998 |
XLogP | 0.6 |
Formal Charge | -1 |
Heavy Atom Count | 1 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Isotope Atom Count | 0 |
Covalently-Bonded Unit Count | 1 |
ADMET
Model | Result | Probability |
---|---|---|
Absorption | ||
Blood-Brain Barrier | BBB+ | 0.9822 |
Human Intestinal Absorption | HIA+ | 0.9456 |
Caco-2 Permeability | Caco2+ | 0.7066 |
P-glycoprotein Substrate | Non-substrate | 0.8959 |
P-glycoprotein Inhibitor | Non-inhibitor | 0.9793 |
Non-inhibitor | 0.9814 | |
Renal Organic Cation Transporter | Non-inhibitor | 0.9269 |
Distribution | ||
Subcellular localization | Lysosome | 0.4936 |
Metabolism | ||
CYP450 2C9 Substrate | Non-substrate | 0.8433 |
CYP450 2D6 Substrate | Non-substrate | 0.7451 |
CYP450 3A4 Substrate | Non-substrate | 0.7941 |
CYP450 1A2 Inhibitor | Non-inhibitor | 0.7925 |
CYP450 2C9 Inhibitor | Non-inhibitor | 0.8935 |
CYP450 2D6 Inhibitor | Non-inhibitor | 0.9444 |
CYP450 2C19 Inhibitor | Non-inhibitor | 0.9194 |
CYP450 3A4 Inhibitor | Non-inhibitor | 0.9627 |
CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.9250 |
Excretion | ||
Toxicity | ||
Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9658 |
Non-inhibitor | 0.9549 | |
AMES Toxicity | Non AMES toxic | 0.8722 |
Carcinogens | Carcinogens | 0.7363 |
Fish Toxicity | Low FHMT | 0.5779 |
Tetrahymena Pyriformis Toxicity | High TPT | 0.6557 |
Honey Bee Toxicity | High HBT | 0.8111 |
Biodegradation | Not ready biodegradable | 0.5851 |
Acute Oral Toxicity | III | 0.6819 |
Carcinogenicity (Three-class) | Non-required | 0.4669 |
Model | Value | Unit |
---|---|---|
Absorption | ||
Aqueous solubility | -0.5761 | LogS |
Caco-2 Permeability | 1.5705 | LogPapp, cm/s |
Distribution | ||
Metabolism | ||
Excretion | ||
Toxicity | ||
Rat Acute Toxicity | 2.3596 | LD50, mol/kg |
Fish Toxicity | 0.9996 | pLC50, mg/L |
Tetrahymena Pyriformis Toxicity | 0.0413 | pIGC50, ug/L |
MRLs
Food | Product Code | Country | MRLs | Application Date | Notes |
---|---|---|---|---|---|
Citrus fruits | 0110000 | European Union | 2* | 01/09/2008 | |
Grapefruits (Natsudaidais, Shaddocks/pomelos, Sweeties/oroblancos, Tangelolos, Tangelos (except minneolas)/Ugli®, Other hybrids of Citrus paradisi, not elsewhere mentioned,) | 0110010 | European Union | 2* | 01/09/2008 | |
Oranges (Bergamots, Bitter oranges/sour oranges, Blood oranges, Cara caras, Chinottos, Trifoliate oranges, Other hybrids of Citrus sinensis, not elsewhere mentioned,) | 0110020 | European Union | 2* | 01/09/2008 | |
Lemons (Buddha's hands/Buddha's fingers, Citrons,) | 0110030 | European Union | 2* | 01/09/2008 | |
Limes (Indian sweet limes/Palestine sweet limes, Kaffir limes, Sweet limes/mosambis, Tahiti limes, Limequats,) | 0110040 | European Union | 2* | 01/09/2008 | |
Mandarins (Calamondins, Clementines, Cleopatra mandarins, Minneolas, Satsumas/clausellinas, Tangerines/dancy mandarins, Tangors, Other hybrids of Citrus reticulata, not elsewhere mentioned,) | 0110050 | European Union | 2* | 01/09/2008 | |
Others (2) | 0110990 | European Union | 2* | 01/09/2008 | |
Tree nuts | 0120000 | European Union | 25 | 01/09/2008 | |
Almonds (Apricot kernels, Bitter almonds, Canarium nuts/galip nuts, Pili nuts, Okari nuts,) | 0120010 | European Union | 25 | 01/09/2008 | |
Brazil nuts | 0120020 | European Union | 25 | 01/09/2008 | |
Cashew nuts | 0120030 | European Union | 25 | 01/09/2008 | |
Chestnuts | 0120040 | European Union | 25 | 01/09/2008 | |
Coconuts (Areca nuts/betel nuts,) | 0120050 | European Union | 25 | 01/09/2008 | |
Hazelnuts/cobnuts (Acorns, Filberts,) | 0120060 | European Union | 25 | 01/09/2008 | |
Macadamias | 0120070 | European Union | 25 | 01/09/2008 | |
Pecans (Hickory nuts,) | 0120080 | European Union | 25 | 01/09/2008 | |
Pistachios | 0120100 | European Union | 25 | 01/09/2008 | |
Walnuts | 0120110 | European Union | 25 | 01/09/2008 | |
Others (2) | 0120990 | European Union | 25 | 01/09/2008 | |
Pome fruits | 0130000 | European Union | 2* | 01/09/2008 |
References
Title | Journal | Date | Pubmed ID |
---|---|---|---|
Ultrasensitive electrochemical immuno-sensing platform based on gold nanoparticles triggering chlorpyrifos detection in fruits and vegetables. | Biosens Bioelectron | 2018 May 15 | 29346076 |
Neuroprotective effect of berberine against environmental heavy metals-inducedneurotoxicity and Alzheimer's-like disease in rats. | Food Chem Toxicol | 2018 Jan | 29170048 |
Age-Related Patterns in Trace Element Content Vary Between Bone and Teeth of the European Roe Deer (Capreolus capreolus). | Arch Environ Contam Toxicol | 2018 Feb | 29071367 |
Antimicrobial Effect of Toothpastes Containing Fluoride, Xylitol, orXylitol-Probiotic on Salivary Streptococcus mutans and Lactobacillus in Children. | Niger J Clin Pract | 2018 Feb | 29465044 |
Fluoride distribution and contamination in the water, soil and plants continuum and its remedial technologies, an Indian perspective- a review. | Environ Pollut | 2018 Aug | 29649763 |
Effects of fluorine on crops, soil exoenzyme activities, and earthworms in terrestrial ecosystems. | Ecotoxicol Environ Saf | 2018 Apr 30 | 29304414 |
Antibacterial potency and fluoride release of a glass ionomer restorativematerial containing different concentrations of natural and chemical products: Anin-vitro comparative study. | J Clin Exp Dent | 2018 Apr 1 | 29750090 |
Pharmacological values and therapeutic properties of black tea (Camelliasinensis): A comprehensive overview. | Biomed Pharmacother | 2018 Apr | 29482046 |
Fluoride-Induced Autophagy via the Regulation of Phosphorylation of MammalianTargets of Rapamycin in Mice Leydig Cells. | J Agric Food Chem | 2017 Oct 11 | 28927274 |
Accumulation and interaction of fluoride and cadmium in the soil-wheat plant system from the wastewater irrigated soil of an oasis region in northwest China. | Sci Total Environ | 2017 Oct 1 | 28390313 |
Effects of Excess Dietary Fluoride on Serum Biochemical Indices, Egg Quality, andConcentrations of Fluoride in Soft Organs, Eggs, and Serum of Laying Hens. | Biol Trace Elem Res | 2017 Nov | 28281223 |
Mineralization-defects are comparable in fluorotic impacted human teeth andfluorotic mouse incisors. | Arch Oral Biol | 2017 Nov | 28806687 |
Adsorptive removal of fluoride from drinking water using porous starch loadedwith common metal ions. | Carbohydr Polym | 2017 Mar 15 | 28115103 |
Structure-activity relationship of ochratoxin A and synthesized derivatives: importance of amino acid and halogen moiety for cytotoxicity. | Arch Toxicol | 2017 Mar | 27422291 |
Lebanese children are iodine deficient and urinary sodium and fluoride excretion are weak positive predictors of urinary iodine. | Eur J Nutr | 2017 Mar | 26650194 |
Chemical characterization of surface snow in Istanbul (NW Turkey) and theirassociation with atmospheric circulations. | Environ Monit Assess | 2017 Jun | 28523580 |
Trace elements have beneficial, as well as detrimental effects on bone homeostasis. | Physiol Res | 2017 Jul 18 | 28248532 |
Determination of Fluoride in Organic and Non-organic Wines. | Biol Trace Elem Res | 2017 Jul | 28028786 |
Assessment of arsenic, fluoride, bacteria, and other contaminants in drinkingwater sources for rural communities of Kasur and other districts in Punjab,Pakistan. | Environ Sci Pollut Res Int | 2017 Jan | 27817144 |
Fluorinated Compounds in U.S. Fast Food Packaging. | Environ Sci Technol Lett | 2017 | 30148183 |