Phosphine
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Basic Info
| Common Name | Phosphine(F03462) |
| 2D Structure | |
| Description | Fumigant for cereals, flour, packaged foods Phosphine has been shown to exhibit anti-tumor function (A7737). Phosphine belongs to the family of Other Non-metal Hydrides. These are inorganic compounds in which the heaviest atom bonded to an hydrogen atom is belongs to the class of 'other non-metals'. |
| FRCD ID | F03462 |
| CAS Number | 7803-51-2 |
| PubChem CID | 24404 |
| Formula | H3P |
| IUPAC Name | phosphane |
| InChI Key | XYFCBTPGUUZFHI-UHFFFAOYSA-N |
| InChI | InChI=1S/H3P/h1H3 |
| Canonical SMILES | P |
| Isomeric SMILES | P |
| Wikipedia | Phosphine |
| Synonyms |
Phosphorwasserstoff
Phosphine
phosphane
Hydrogen phosphide
Phosphorus trihydride
7803-51-2
Phosphorus hydride
Phosphorus-31
Fosforowodor
Gas-Ex-B
|
| Classifies |
Pollutant
Pesticide
|
| Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
| Kingdom | Inorganic compounds |
| Superclass | Homogeneous non-metal compounds |
| Class | Homogeneous other non-metal compounds |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Homogeneous other non-metal compounds |
| Alternative Parents | |
| Molecular Framework | Not available |
| Substituents | Homogeneous other non metal |
| Description | This compound belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'. |
Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 33.998 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Complexity | 0 |
| Monoisotopic Mass | 33.997 |
| Exact Mass | 33.997 |
| XLogP | -0.1 |
| Formal Charge | 0 |
| Heavy Atom Count | 1 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 1 |
ADMET
| Model | Result | Probability |
|---|---|---|
| Absorption | ||
| Blood-Brain Barrier | BBB+ | 0.9749 |
| Human Intestinal Absorption | HIA+ | 0.9688 |
| Caco-2 Permeability | Caco2+ | 0.7271 |
| P-glycoprotein Substrate | Non-substrate | 0.8843 |
| P-glycoprotein Inhibitor | Non-inhibitor | 0.9756 |
| Non-inhibitor | 0.9858 | |
| Renal Organic Cation Transporter | Non-inhibitor | 0.9158 |
| Distribution | ||
| Subcellular localization | Lysosome | 0.4873 |
| Metabolism | ||
| CYP450 2C9 Substrate | Non-substrate | 0.8290 |
| CYP450 2D6 Substrate | Non-substrate | 0.8264 |
| CYP450 3A4 Substrate | Non-substrate | 0.8149 |
| CYP450 1A2 Inhibitor | Non-inhibitor | 0.8931 |
| CYP450 2C9 Inhibitor | Non-inhibitor | 0.9419 |
| CYP450 2D6 Inhibitor | Non-inhibitor | 0.9723 |
| CYP450 2C19 Inhibitor | Non-inhibitor | 0.9606 |
| CYP450 3A4 Inhibitor | Non-inhibitor | 0.9824 |
| CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.8924 |
| Excretion | ||
| Toxicity | ||
| Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9489 |
| Non-inhibitor | 0.9757 | |
| AMES Toxicity | Non AMES toxic | 0.9656 |
| Carcinogens | Carcinogens | 0.6575 |
| Fish Toxicity | Low FHMT | 0.6542 |
| Tetrahymena Pyriformis Toxicity | Low TPT | 0.6631 |
| Honey Bee Toxicity | High HBT | 0.8551 |
| Biodegradation | Ready biodegradable | 0.8291 |
| Acute Oral Toxicity | III | 0.6449 |
| Carcinogenicity (Three-class) | Warning | 0.4812 |
| Model | Value | Unit |
|---|---|---|
| Absorption | ||
| Aqueous solubility | -1.1574 | LogS |
| Caco-2 Permeability | 1.4907 | LogPapp, cm/s |
| Distribution | ||
| Metabolism | ||
| Excretion | ||
| Toxicity | ||
| Rat Acute Toxicity | 2.2920 | LD50, mol/kg |
| Fish Toxicity | 1.6189 | pLC50, mg/L |
| Tetrahymena Pyriformis Toxicity | -0.7156 | pIGC50, ug/L |
MRLs
| Food | Product Code | Country | MRLs | Application Date | Notes |
|---|---|---|---|---|---|
| Citrus fruits | 0110000 | European Union | 0.01* | 28/04/2017 | |
| Others (2) | 0233990 | European Union | 0.01* | 28/04/2017 | |
| Hazelnuts/cobnuts (Acorns, Filberts,) | 0120060 | European Union | 0.09 | 28/04/2017 | |
| Oranges (Bergamots, Bitter oranges/sour oranges, Blood oranges, Cara caras, Chinottos, Trifoliate oranges, Other hybrids of Citrus sinensis, not elsewhere mentioned,) | 0110020 | European Union | 0.01* | 28/04/2017 | |
| Lemons (Buddha's hands/Buddha's fingers, Citrons,) | 0110030 | European Union | 0.01* | 28/04/2017 | |
| Limes (Indian sweet limes/Palestine sweet limes, Kaffir limes, Sweet limes/mosambis, Tahiti limes, Limequats,) | 0110040 | European Union | 0.01* | 28/04/2017 | |
| Mandarins (Calamondins, Clementines, Cleopatra mandarins, Minneolas, Satsumas/clausellinas, Tangerines/dancy mandarins, Tangors, Other hybrids of Citrus reticulata, not elsewhere mentioned,) | 0110050 | European Union | 0.01* | 28/04/2017 | |
| Others (2) | 0110990 | European Union | 0.01* | 28/04/2017 | |
| Almonds (Apricot kernels, Bitter almonds, Canarium nuts/galip nuts, Pili nuts, Okari nuts,) | 0120010 | European Union | 0.09 | 28/04/2017 | |
| Brazil nuts | 0120020 | European Union | 0.09 | 28/04/2017 | |
| Cashew nuts | 0120030 | European Union | 0.09 | 28/04/2017 | |
| Chestnuts | 0120040 | European Union | 0.09 | 28/04/2017 | |
| Coconuts (Areca nuts/betel nuts,) | 0120050 | European Union | 0.09 | 28/04/2017 | |
| Macadamias | 0120070 | European Union | 0.09 | 28/04/2017 | |
| Pecans (Hickory nuts,) | 0120080 | European Union | 0.09 | 28/04/2017 | |
| Pistachios | 0120100 | European Union | 0.1 | 28/04/2017 | |
| Walnuts | 0120110 | European Union | 0.09 | 28/04/2017 | |
| Others (2) | 0120990 | European Union | 0.01* | 28/04/2017 | |
| Pome fruits | 0130000 | European Union | 0.01* | 28/04/2017 | |
| Apples (Crab apples/wild apples, Tejocotes,) | 0130010 | European Union | 0.01* | 28/04/2017 |
References
| Title | Journal | Date | Pubmed ID |
|---|---|---|---|
| Uncertainty of pesticide residue concentration determined from ordinary andweighted linear regression curve. | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | 2018Jul | 29521572 |
| Effect of combining adsorption-stripping treatment with acidification on thegrowth of Chlorella vulgaris and nutrient removal from swine wastewater. | Bioresour Technol | 2018 Sep | 29723844 |
| Validation of a dilute and shoot method for quantification of 12 elements byinductively coupled plasma tandem mass spectrometry in human milk and in cow milkpreparations. | J Trace Elem Med Biol | 2018 Sep | 29895368 |
| Hydrologic and water quality performance of permeable pavement with internalwater storage over a clay soil in Durham, North Carolina. | J Environ Manage | 2018 Oct 15 | 30055460 |
| Effects of potassium fertilization on potato starch physicochemical properties. | Int J Biol Macromol | 2018 Oct 1 | 29791875 |
| Adding benefit to wetlands - Valorization of harvested common reed throughmushroom production. | Sci Total Environ | 2018 Oct 1 | 29801232 |
| Particle size distribution mathematical models and properties of suspended solidsin a typical freshwater pond. | Environ Pollut | 2018 Oct | 29804049 |
| At the Intersection of Urbanization, Water, and Food Security: Determination ofSelect Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong. | J Agric Food Chem | 2018 May 23 | 29526083 |
| Combined treatment with Dendrobium candidum and black tea extract promotesosteoprotective activity in ovariectomized estrogen deficient rats and osteoclastformation. | Life Sci | 2018 May 1 | 29544757 |
| Nutritional value and potential chemical food safety hazards of selected Polishsausages as influenced by their traditionality. | Meat Sci | 2018 May | 29367119 |
| Pyrolysis and co-composting of municipal organic waste in Bangladesh: Aquantitative estimate of recyclable nutrients, greenhouse gas emissions, andeconomic benefits. | Waste Manag | 2018 May | 29439929 |
| [An automated direct immersion solid-phase micro extraction-gaschromatography-mass spectrometry (DI-SPME-GCMS) method for determinationpesticides in liquid Chinese herbal health food]. | Wei Sheng Yan Jiu | 2018 May | 30082015 |
| Minerals and Trace Elements in Milk, Milk Products, Infant Formula, andAdult/Pediatric Nutritional Formula, ICP-MS Method: Collaborative Study, AOACFinal Action 2015.06, ISO/DIS 21424, IDF 243. | J AOAC Int | 2018 Mar 1 | 29151407 |
| Phosphorus recovery and reuse by pyrolysis: Applications for agriculture andenvironment. | Chemosphere | 2018 Mar | 29245134 |
| Adsorption of phosphorus by calcium-flour biochar: Isotherm, kinetic andtransformation studies. | Chemosphere | 2018 Mar | 29287274 |
| Dietary intake of inorganic phosphorus has a stronger influence onvascular-endothelium function than organic phosphorus. | J Clin Biochem Nutr | 2018 Mar | 29610557 |
| Phosphorus-loaded biochar changes soil heavy metals availability and uptakepotential of maize (Zea mays L.) plants. | Chemosphere | 2018 Mar | 29220749 |
| The Impact of Additives on the Phosphorus, Potassium, and Sodium Content ofCommonly Consumed Meat, Poultry, and Fish Products Among Patients With ChronicKidney Disease. | J Ren Nutr | 2018 Mar | 29146137 |
| Effects of stocking density on growth performance, meat quality and tibiadevelopment of Pekin ducks. | Anim Sci J | 2018 Jun | 29682864 |
| Genetic (co)variances between milk mineral concentration and chemical compositionin lactating Holstein-Friesian dairy cows. | Animal | 2018 Jul 6:1-10 | 29976269 |
Targets
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX4I1
- Uniprot ID:
- P13073
- Molecular Weight:
- 19576.6 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Iron ion binding
- Specific Function:
- Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
- Gene Name:
- MT-CO1
- Uniprot ID:
- P00395
- Molecular Weight:
- 57040.91 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
- Gene Name:
- MT-CO2
- Uniprot ID:
- P00403
- Molecular Weight:
- 25564.73 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Metal ion binding
- Specific Function:
- This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX5A
- Uniprot ID:
- P20674
- Molecular Weight:
- 16761.985 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Metal ion binding
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX5B
- Uniprot ID:
- P10606
- Molecular Weight:
- 13695.57 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX6A1
- Uniprot ID:
- P12074
- Molecular Weight:
- 12154.8 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX6A2
- Uniprot ID:
- Q02221
- Molecular Weight:
- 10815.32 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- Connects the two COX monomers into the physiological dimeric form.
- Gene Name:
- COX6B1
- Uniprot ID:
- P14854
- Molecular Weight:
- 10192.345 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- Connects the two COX monomers into the physiological dimeric form.
- Gene Name:
- COX6B2
- Uniprot ID:
- Q6YFQ2
- Molecular Weight:
- 10528.905 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX6C
- Uniprot ID:
- P09669
- Molecular Weight:
- 8781.36 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX7A1
- Uniprot ID:
- P24310
- Molecular Weight:
- 9117.44 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX7A2
- Uniprot ID:
- P14406
- Molecular Weight:
- 9395.89 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates.
- Gene Name:
- COX7B
- Uniprot ID:
- P24311
- Molecular Weight:
- 9160.485 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX7B2
- Uniprot ID:
- Q8TF08
- Molecular Weight:
- 9077.43 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX8A
- Uniprot ID:
- P10176
- Molecular Weight:
- 7579.0 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX8C
- Uniprot ID:
- Q7Z4L0
- Molecular Weight:
- 8128.575 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Gene Name:
- COX7A2P2
- Uniprot ID:
- O60397
- Molecular Weight:
- 11840.715 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- Subunits I, II and III form the functional core of the enzyme complex.
- Gene Name:
- MT-CO3
- Uniprot ID:
- P00414
- Molecular Weight:
- 29950.6 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX4I2
- Uniprot ID:
- Q96KJ9
- Molecular Weight:
- 20010.02 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]
- General Function:
- Cytochrome-c oxidase activity
- Specific Function:
- This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
- Gene Name:
- COX7C
- Uniprot ID:
- P15954
- Molecular Weight:
- 7245.45 Da
- Mechanism of Action:
- Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to multi-organ dysfunction.
References
- Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol (Phila). 2006;44(2):155-8. [16615671 ]