Nickelocene
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Basic Info
| Common Name | Nickelocene(F04252) |
| 2D Structure | |
| Description | Nickelocene is an organonickel compound with the formula Ni(‘‡5-C5H5)2. Nickel is a chemical compound with the atomic number 28. Also known as bis(cyclopentadienyl)nickel or NiCp2, this bright green paramagnetic solid is found abundantly in nature in laterite ore minerals, such as limonite, garnierite, and pentlandite. Nickel has a biological role and is found in certain enzymes, including urease, hydrogenase, methylcoenzyme M reductase, and carbon monoxide dehydrogenase. (L40, L41) |
| FRCD ID | F04252 |
| CAS Number | 1271-28-9 |
| PubChem CID | 16219780 |
| Formula | C10H10Ni |
| IUPAC Name | cyclopentane;nickel |
| InChI Key | FOOKRXHSBKEWSE-UHFFFAOYSA-N |
| InChI | InChI=1S/2C5H5.Ni/c2*1-2-4-5-3-1;/h2*1-5H; |
| Canonical SMILES | [CH]1[CH][CH][CH][CH]1.[CH]1[CH][CH][CH][CH]1.[Ni] |
| Isomeric SMILES | [CH]1[CH][CH][CH][CH]1.[CH]1[CH][CH][CH][CH]1.[Ni] |
| Synonyms |
2C5H5.Ni
5117AF
SC10028
|
| Classifies |
Pollutant
|
| Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
| Kingdom | Organic compounds |
| Superclass | Organoheterocyclic compounds |
| Class | Metalloheterocyclic compounds |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Metalloheterocyclic compounds |
| Alternative Parents | |
| Molecular Framework | Aliphatic heteropolycyclic compounds |
| Substituents | Metalloheterocycle - Organonickel compound - Transition metal alkyl - Hydrocarbon derivative - Organic salt - Organometallic compound - Organic transition metal moeity - Aliphatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as metalloheterocyclic compounds. These are heterocyclic compounds contain one metal ring atom. |
Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 188.883 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Complexity | 11.6 |
| Monoisotopic Mass | 188.014 |
| Exact Mass | 188.014 |
| Formal Charge | 0 |
| Heavy Atom Count | 11 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 3 |
ADMET
| Model | Result | Probability |
|---|---|---|
| Absorption | ||
| Blood-Brain Barrier | BBB+ | 0.9852 |
| Human Intestinal Absorption | HIA+ | 0.9896 |
| Caco-2 Permeability | Caco2+ | 0.7344 |
| P-glycoprotein Substrate | Non-substrate | 0.8909 |
| P-glycoprotein Inhibitor | Non-inhibitor | 0.9764 |
| Non-inhibitor | 0.9910 | |
| Renal Organic Cation Transporter | Non-inhibitor | 0.8797 |
| Distribution | ||
| Subcellular localization | Lysosome | 0.6422 |
| Metabolism | ||
| CYP450 2C9 Substrate | Non-substrate | 0.8618 |
| CYP450 2D6 Substrate | Non-substrate | 0.8598 |
| CYP450 3A4 Substrate | Non-substrate | 0.8110 |
| CYP450 1A2 Inhibitor | Non-inhibitor | 0.8519 |
| CYP450 2C9 Inhibitor | Non-inhibitor | 0.9263 |
| CYP450 2D6 Inhibitor | Non-inhibitor | 0.9595 |
| CYP450 2C19 Inhibitor | Non-inhibitor | 0.9285 |
| CYP450 3A4 Inhibitor | Non-inhibitor | 0.9725 |
| CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.8452 |
| Excretion | ||
| Toxicity | ||
| Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9624 |
| Non-inhibitor | 0.9749 | |
| AMES Toxicity | Non AMES toxic | 0.9793 |
| Carcinogens | Non-carcinogens | 0.5056 |
| Fish Toxicity | Low FHMT | 0.6156 |
| Tetrahymena Pyriformis Toxicity | High TPT | 0.7902 |
| Honey Bee Toxicity | High HBT | 0.8202 |
| Biodegradation | Ready biodegradable | 0.7348 |
| Acute Oral Toxicity | II | 0.5336 |
| Carcinogenicity (Three-class) | Warning | 0.4784 |
| Model | Value | Unit |
|---|---|---|
| Absorption | ||
| Aqueous solubility | -2.1606 | LogS |
| Caco-2 Permeability | 1.6416 | LogPapp, cm/s |
| Distribution | ||
| Metabolism | ||
| Excretion | ||
| Toxicity | ||
| Rat Acute Toxicity | 2.0985 | LD50, mol/kg |
| Fish Toxicity | 1.5362 | pLC50, mg/L |
| Tetrahymena Pyriformis Toxicity | -0.4577 | pIGC50, ug/L |
Targets
- General Function:
- L-ascorbic acid binding
- Specific Function:
- Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
- Gene Name:
- ALKBH3
- Uniprot ID:
- Q96Q83
- Molecular Weight:
- 33374.495 Da
- Mechanism of Action:
- Nickel substitutes for iron in alpha-ketoglutarate-dependent dioxygenases, inhibiting DNA repair.
References
- Chen H, Costa M: Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009 Feb;22(1):191-6. doi: 10.1007/s10534-008-9190-3. Epub 2008 Dec 19. [19096759 ]
- General Function:
- Protein domain specific binding
- Specific Function:
- Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
- Gene Name:
- PPP3R1
- Uniprot ID:
- P63098
- Molecular Weight:
- 19299.785 Da
- Mechanism of Action:
- Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin.
References
- King MM, Huang CY: Activation of calcineurin by nickel ions. Biochem Biophys Res Commun. 1983 Aug 12;114(3):955-61. [6311199 ]
- General Function:
- Calcium ion binding
- Specific Function:
- Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).
- Gene Name:
- PPP3R2
- Uniprot ID:
- Q96LZ3
- Molecular Weight:
- 19533.065 Da
- Mechanism of Action:
- Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin.
References
- King MM, Huang CY: Activation of calcineurin by nickel ions. Biochem Biophys Res Commun. 1983 Aug 12;114(3):955-61. [6311199 ]
- General Function:
- Peptidyl-proline 4-dioxygenase activity
- Specific Function:
- Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferentially recognized via a LXXLAP motif.
- Gene Name:
- EGLN2
- Uniprot ID:
- Q96KS0
- Molecular Weight:
- 43650.03 Da
- Mechanism of Action:
- Nickel substitutes for iron in hypoxia-inducible factor prolyl hydroxylases, inhibiting their enzyme activity. This results in the accumulation of hypoxia inducible factor 1 alpha, causing hypoxia-mimic stress.
References
- Chen H, Costa M: Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009 Feb;22(1):191-6. doi: 10.1007/s10534-008-9190-3. Epub 2008 Dec 19. [19096759 ]
- General Function:
- Poly(a) rna binding
- Specific Function:
- Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
- Gene Name:
- H1F0
- Uniprot ID:
- P07305
- Molecular Weight:
- 20862.775 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Poly(a) rna binding
- Specific Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
- Gene Name:
- HIST1H1C
- Uniprot ID:
- P16403
- Molecular Weight:
- 21364.57 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Poly(a) rna binding
- Specific Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
- Gene Name:
- HIST1H1D
- Uniprot ID:
- P16402
- Molecular Weight:
- 22349.71 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Poly(a) rna binding
- Specific Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
- Gene Name:
- HIST1H1B
- Uniprot ID:
- P16401
- Molecular Weight:
- 22579.945 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
- Gene Name:
- HIST1H1T
- Uniprot ID:
- P22492
- Molecular Weight:
- 22018.82 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Poly(a) rna binding
- Specific Function:
- Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
- Gene Name:
- H1FX
- Uniprot ID:
- Q92522
- Molecular Weight:
- 22487.0 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Enzyme binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2AG
- Uniprot ID:
- P0C0S8
- Molecular Weight:
- 14091.375 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2AA
- Uniprot ID:
- Q96QV6
- Molecular Weight:
- 14233.39 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2AB
- Uniprot ID:
- P04908
- Molecular Weight:
- 14135.385 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2AC
- Uniprot ID:
- Q93077
- Molecular Weight:
- 14105.355 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2AH
- Uniprot ID:
- Q96KK5
- Molecular Weight:
- 13906.145 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2AJ
- Uniprot ID:
- Q99878
- Molecular Weight:
- 13936.175 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST2H2AA3
- Uniprot ID:
- Q6FI13
- Molecular Weight:
- 14095.385 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST2H2AB
- Uniprot ID:
- Q8IUE6
- Molecular Weight:
- 13995.205 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST2H2AC
- Uniprot ID:
- Q16777
- Molecular Weight:
- 13988.26 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST3H2A
- Uniprot ID:
- Q7L7L0
- Molecular Weight:
- 14121.355 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.
- Gene Name:
- H2AFB2
- Uniprot ID:
- P0C5Z0
- Molecular Weight:
- 12713.25 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- H2AFJ
- Uniprot ID:
- Q9BTM1
- Molecular Weight:
- 14019.3 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).
- Gene Name:
- H2AFV
- Uniprot ID:
- Q71UI9
- Molecular Weight:
- 13508.575 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Rna polymerase ii distal enhancer sequence-specific dna binding
- Specific Function:
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
- Gene Name:
- H2AFZ
- Uniprot ID:
- P0C0S5
- Molecular Weight:
- 13552.635 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
- Gene Name:
- HIST1H2BJ
- Uniprot ID:
- P06899
- Molecular Weight:
- 13904.055 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2BB
- Uniprot ID:
- P33778
- Molecular Weight:
- 13950.075 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
- Gene Name:
- HIST1H2BC
- Uniprot ID:
- P62807
- Molecular Weight:
- 13906.035 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2BH
- Uniprot ID:
- Q93079
- Molecular Weight:
- 13892.005 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2BL
- Uniprot ID:
- Q99880
- Molecular Weight:
- 13952.095 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2BM
- Uniprot ID:
- Q99879
- Molecular Weight:
- 13989.175 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2BN
- Uniprot ID:
- Q99877
- Molecular Weight:
- 13922.035 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2BO
- Uniprot ID:
- P23527
- Molecular Weight:
- 13906.025 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
- Gene Name:
- HIST2H2BE
- Uniprot ID:
- Q16778
- Molecular Weight:
- 13920.055 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST3H2BB
- Uniprot ID:
- Q8N257
- Molecular Weight:
- 13908.005 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- H2BFM
- Uniprot ID:
- P0C1H6
- Molecular Weight:
- 17001.165 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function.
- Gene Name:
- H2BFWT
- Uniprot ID:
- Q7Z2G1
- Molecular Weight:
- 19618.3 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).
- Gene Name:
- CENPA
- Uniprot ID:
- P49450
- Molecular Weight:
- 15990.395 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Histone binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H3A
- Uniprot ID:
- P68431
- Molecular Weight:
- 15403.925 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Histone binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST2H3A
- Uniprot ID:
- Q71DI3
- Molecular Weight:
- 15387.865 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Nucleosomal dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
- Gene Name:
- H3F3C
- Uniprot ID:
- Q6NXT2
- Molecular Weight:
- 15213.57 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Protein domain specific binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H4A
- Uniprot ID:
- P62805
- Molecular Weight:
- 11367.3 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
- Gene Name:
- HIST1H4G
- Uniprot ID:
- Q99525
- Molecular Weight:
- 11009.065 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Zinc ion binding
- Specific Function:
- Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
- Gene Name:
- KDM4A
- Uniprot ID:
- O75164
- Molecular Weight:
- 120661.265 Da
- Mechanism of Action:
- Nickel substitutes for iron in jmjC domain-containing histone demethylation proteins, inhibiting their demethylation activity.
References
- Chen H, Costa M: Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009 Feb;22(1):191-6. doi: 10.1007/s10534-008-9190-3. Epub 2008 Dec 19. [19096759 ]
- General Function:
- Dna binding
- Specific Function:
- Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
- Gene Name:
- PRM2
- Uniprot ID:
- P04554
- Molecular Weight:
- 13050.695 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity).
- Gene Name:
- PRM3
- Uniprot ID:
- Q9NNZ6
- Molecular Weight:
- 11232.01 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST2H2BD
- Uniprot ID:
- Q6DRA6
- Molecular Weight:
- 18017.875 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Protein serine/threonine phosphatase activity
- Specific Function:
- Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
- Gene Name:
- PPP3CA
- Uniprot ID:
- Q08209
- Molecular Weight:
- 58687.27 Da
- Mechanism of Action:
- Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin.
References
- King MM, Huang CY: Activation of calcineurin by nickel ions. Biochem Biophys Res Commun. 1983 Aug 12;114(3):955-61. [6311199 ]
- General Function:
- Protein serine/threonine phosphatase activity
- Specific Function:
- Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
- Gene Name:
- PPP3CB
- Uniprot ID:
- P16298
- Molecular Weight:
- 59023.735 Da
- Mechanism of Action:
- Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin.
References
- King MM, Huang CY: Activation of calcineurin by nickel ions. Biochem Biophys Res Commun. 1983 Aug 12;114(3):955-61. [6311199 ]
- General Function:
- Phosphoprotein phosphatase activity
- Specific Function:
- Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
- Gene Name:
- PPP3CC
- Uniprot ID:
- P48454
- Molecular Weight:
- 58128.865 Da
- Mechanism of Action:
- Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin.
References
- King MM, Huang CY: Activation of calcineurin by nickel ions. Biochem Biophys Res Commun. 1983 Aug 12;114(3):955-61. [6311199 ]
- General Function:
- Dna binding
- Specific Function:
- Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
- Gene Name:
- PRM1
- Uniprot ID:
- P04553
- Molecular Weight:
- 6822.9 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Ferrous iron binding
- Specific Function:
- Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
- Gene Name:
- ALKBH2
- Uniprot ID:
- Q6NS38
- Molecular Weight:
- 29322.22 Da
- Mechanism of Action:
- Nickel substitutes for iron in alpha-ketoglutarate-dependent dioxygenases, inhibiting DNA repair.
References
- Chen H, Costa M: Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009 Feb;22(1):191-6. doi: 10.1007/s10534-008-9190-3. Epub 2008 Dec 19. [19096759 ]
- General Function:
- Peptidyl-proline dioxygenase activity
- Specific Function:
- Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
- Gene Name:
- EGLN1
- Uniprot ID:
- Q9GZT9
- Molecular Weight:
- 46020.585 Da
- Mechanism of Action:
- Nickel substitutes for iron in hypoxia-inducible factor prolyl hydroxylases, inhibiting their enzyme activity. This results in the accumulation of hypoxia inducible factor 1 alpha, causing hypoxia-mimic stress.
References
- Chen H, Costa M: Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009 Feb;22(1):191-6. doi: 10.1007/s10534-008-9190-3. Epub 2008 Dec 19. [19096759 ]
- General Function:
- Peptidyl-proline 4-dioxygenase activity
- Specific Function:
- Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation. Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway. Target proteins are preferentially recognized via a LXXLAP motif.
- Gene Name:
- EGLN3
- Uniprot ID:
- Q9H6Z9
- Molecular Weight:
- 27261.06 Da
- Mechanism of Action:
- Nickel substitutes for iron in hypoxia-inducible factor prolyl hydroxylases, inhibiting their enzyme activity. This results in the accumulation of hypoxia inducible factor 1 alpha, causing hypoxia-mimic stress.
References
- Chen H, Costa M: Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009 Feb;22(1):191-6. doi: 10.1007/s10534-008-9190-3. Epub 2008 Dec 19. [19096759 ]
- General Function:
- Chromatin dna binding
- Specific Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
- Gene Name:
- HIST1H1A
- Uniprot ID:
- Q02539
- Molecular Weight:
- 21841.89 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Poly(a) rna binding
- Specific Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
- Gene Name:
- HIST1H1E
- Uniprot ID:
- P10412
- Molecular Weight:
- 21865.02 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Nucleosomal dna binding
- Specific Function:
- May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).
- Gene Name:
- H1FOO
- Uniprot ID:
- Q8IZA3
- Molecular Weight:
- 35813.185 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2AD
- Uniprot ID:
- P20671
- Molecular Weight:
- 14107.375 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134).
- Specific Function:
- Dna binding
- Gene Name:
- H2AFB1
- Uniprot ID:
- P0C5Y9
- Molecular Weight:
- 12697.21 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Histone binding
- Specific Function:
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
- Gene Name:
- H2AFX
- Uniprot ID:
- P16104
- Molecular Weight:
- 15144.45 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2BA
- Uniprot ID:
- Q96A08
- Molecular Weight:
- 14167.38 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST1H2BD
- Uniprot ID:
- P58876
- Molecular Weight:
- 13936.065 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
- Gene Name:
- HIST1H2BK
- Uniprot ID:
- O60814
- Molecular Weight:
- 13890.035 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST2H2BF
- Uniprot ID:
- Q5QNW6
- Molecular Weight:
- 13920.065 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Dna binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
- Gene Name:
- H2BFS
- Uniprot ID:
- P57053
- Molecular Weight:
- 13944.085 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Histone binding
- Specific Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- HIST3H3
- Uniprot ID:
- Q16695
- Molecular Weight:
- 15508.105 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Rna polymerase ii distal enhancer sequence-specific dna binding
- Specific Function:
- Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- Gene Name:
- H3F3A
- Uniprot ID:
- P84243
- Molecular Weight:
- 15327.745 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html
- General Function:
- Transcription regulatory region sequence-specific dna binding
- Specific Function:
- Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
- Gene Name:
- KDM3A
- Uniprot ID:
- Q9Y4C1
- Molecular Weight:
- 147339.98 Da
- Mechanism of Action:
- Nickel substitutes for iron in jmjC domain-containing histone demethylation proteins, inhibiting their demethylation activity.
References
- Chen H, Costa M: Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity. Biometals. 2009 Feb;22(1):191-6. doi: 10.1007/s10534-008-9190-3. Epub 2008 Dec 19. [19096759 ]
- General Function:
- Dna binding
- Specific Function:
- Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity).
- Gene Name:
- H1FNT
- Uniprot ID:
- Q75WM6
- Molecular Weight:
- 28115.69 Da
- Mechanism of Action:
- Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression.
References
- ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). : http://www.atsdr.cdc.gov/toxprofiles/tp15.html