1,2,7,9-Tetrachlorodibenzofuran
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Basic Info
| Common Name | 1,2,7,9-Tetrachlorodibenzofuran(F04574) |
| 2D Structure | |
| Description | Chlorinated dibenzofurans (CDFs) are a family of chemical that contain one to eight chlorine atoms attached to the carbon atoms of the parent chemical, dibenzofuran. The CDF family contains 135 individual compounds (known as congeners) with varying harmful health and environmental effects. Of these 135 compounds, those that contain chlorine atoms at the 2,3,7,8-positions of the parent dibenzofuran molecule are especially harmful. Other than for laboratory use of small amounts of CDFs for research and development purposes, these chemicals are not deliberately produced by industry. Most CDFs are produced in very small amounts as unwanted impurities of certain products and processes utilizing chlorinated compounds. Only a few of the 135 CDF compounds have been produced in large enough quantities so that their properties, such as color, smell, taste, and toxicity could be studied. (L952) |
| FRCD ID | F04574 |
| CAS Number | 83704-26-1 |
| PubChem CID | 55107 |
| Formula | C12H4Cl4O |
| IUPAC Name | 1,2,7,9-tetrachlorodibenzofuran |
| InChI Key | PDMFRPIFZAKMLH-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H4Cl4O/c13-5-3-7(15)10-9(4-5)17-8-2-1-6(14)12(16)11(8)10/h1-4H |
| Canonical SMILES | C1=CC(=C(C2=C1OC3=CC(=CC(=C32)Cl)Cl)Cl)Cl |
| Isomeric SMILES | C1=CC(=C(C2=C1OC3=CC(=CC(=C32)Cl)Cl)Cl)Cl |
| Synonyms |
Dibenzofuran, 1,2,7,9-tetrachloro
1,2,7,9-TETRACHLORODIBENZOFURAN
UNII-EO5HN0F1TK
EO5HN0F1TK
83704-26-1
Dibenzofuran, 1,2,7,9-tetrachloro-
AC1L1IDO
CTK5F0976
DTXSID40232540
PDMFRPIFZAKMLH-UHFFFAOYSA-N
|
| Classifies |
Pollutant
Pesticide
|
| Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
| Kingdom | Organic compounds |
| Superclass | Organoheterocyclic compounds |
| Class | Benzofurans |
| Subclass | Dibenzofurans |
| Intermediate Tree Nodes | Chlorinated dibenzofurans |
| Direct Parent | Polychlorinated dibenzofurans |
| Alternative Parents | |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Polychlorinated dibenzofuran - Benzenoid - Aryl halide - Aryl chloride - Heteroaromatic compound - Furan - Oxacycle - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Organochloride - Organohalogen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as polychlorinated dibenzofurans. These are organic compounds containing two or more chlorine atoms attached to a dibenzofuran moiety. |
Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 305.963 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Complexity | 300 |
| Monoisotopic Mass | 303.902 |
| Exact Mass | 305.899 |
| XLogP | 5.9 |
| Formal Charge | 0 |
| Heavy Atom Count | 17 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 1 |
ADMET
| Model | Result | Probability |
|---|---|---|
| Absorption | ||
| Blood-Brain Barrier | BBB+ | 0.9939 |
| Human Intestinal Absorption | HIA+ | 1.0000 |
| Caco-2 Permeability | Caco2+ | 0.7194 |
| P-glycoprotein Substrate | Non-substrate | 0.7438 |
| P-glycoprotein Inhibitor | Non-inhibitor | 0.7751 |
| Non-inhibitor | 0.6770 | |
| Renal Organic Cation Transporter | Non-inhibitor | 0.7563 |
| Distribution | ||
| Subcellular localization | Mitochondria | 0.4850 |
| Metabolism | ||
| CYP450 2C9 Substrate | Non-substrate | 0.7835 |
| CYP450 2D6 Substrate | Non-substrate | 0.8670 |
| CYP450 3A4 Substrate | Non-substrate | 0.6689 |
| CYP450 1A2 Inhibitor | Inhibitor | 0.9510 |
| CYP450 2C9 Inhibitor | Inhibitor | 0.5966 |
| CYP450 2D6 Inhibitor | Non-inhibitor | 0.8330 |
| CYP450 2C19 Inhibitor | Inhibitor | 0.8819 |
| CYP450 3A4 Inhibitor | Non-inhibitor | 0.7010 |
| CYP Inhibitory Promiscuity | High CYP Inhibitory Promiscuity | 0.8940 |
| Excretion | ||
| Toxicity | ||
| Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.7823 |
| Non-inhibitor | 0.8121 | |
| AMES Toxicity | Non AMES toxic | 0.5405 |
| Carcinogens | Non-carcinogens | 0.8040 |
| Fish Toxicity | High FHMT | 0.9368 |
| Tetrahymena Pyriformis Toxicity | High TPT | 0.9987 |
| Honey Bee Toxicity | High HBT | 0.7402 |
| Biodegradation | Not ready biodegradable | 0.9754 |
| Acute Oral Toxicity | I | 0.7922 |
| Carcinogenicity (Three-class) | Danger | 0.5571 |
| Model | Value | Unit |
|---|---|---|
| Absorption | ||
| Aqueous solubility | -5.6993 | LogS |
| Caco-2 Permeability | 1.7144 | LogPapp, cm/s |
| Distribution | ||
| Metabolism | ||
| Excretion | ||
| Toxicity | ||
| Rat Acute Toxicity | 4.3028 | LD50, mol/kg |
| Fish Toxicity | -0.5496 | pLC50, mg/L |
| Tetrahymena Pyriformis Toxicity | 1.8293 | pIGC50, ug/L |
References
| Title | Journal | Date | Pubmed ID |
|---|---|---|---|
| Citrus peel polymethoxyflavones, sudachitin and nobiletin, induce distinct cellular responses in human keratinocyte HaCaT cells. | Biosci Biotechnol Biochem | 2018 Sep 5 | 30185129 |
| Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling. | J Agric Food Chem | 2018 Sep 5 | 30113849 |
| Oleic Acid Alleviates Cadmium-Induced Oxidative Damage in Rat by Its Radicals Scavenging Activity. | Biol Trace Elem Res | 2018 Sep 29 | 30267311 |
| Adducts formed during protein digestion decreased the toxicity of five carbonyl compounds against Caco-2 cells. | J Hazard Mater | 2018 Sep 24 | 30300775 |
| Evaluation of chemical extractants to assess metals phytoavailability in Brazilian municipal solid waste composts. | Environ Pollut | 2018 Sep 21 | 30267920 |
| Carcinogenic and Non-carcinogenic Risk Assessment of Heavy Metals in Groundwater Wells in Neyshabur Plain, Iran. | Biol Trace Elem Res | 2018 Sep 17 | 30225757 |
| Prevalence of Enterotoxigenic Staphylococcus aureus and Shiga Toxin Producing Escherichia coli in Fish in Egypt: Quality Parameters and Public Health Hazard. | Vector Borne Zoonotic Dis | 2018 Sep 15 | 30222525 |
| Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome. | Toxicol Lett | 2018 Sep 15 | 29800716 |
| Graphene quantum dots-based nano-biointerface platform for food toxin detection. | Anal Bioanal Chem | 2018 Sep 14 | 30218125 |
| Dye Removal from Water and Wastewater Using Various Physical, Chemical, and Biological Processes. | J AOAC Int | 2018 Sep 1 | 29669626 |
| Obesity Prevention and Treatment in Primary Care. | Acad Pediatr | 2018 Sep - Oct | 29852268 |
| Effect of a one-off sporidesmin challenge on the milk production of dairy cows. | N Z Vet J | 2018 Sep | 29949719 |
| Evaluation of aflatoxin and Aspergillus sp. contamination in raw peanuts and peanut-based products along this supply chain in Malaysia. | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | 2018 Sep | 29912639 |
| Heavy metal and microbial safety assessment of raw and cooked pumpkin and <i>Amaranthus viridis</i> leaves grown in Abakaliki, Nigeria. | Food Sci Nutr | 2018 Sep | 30258596 |
| Bioactivity-Guided Isolation of Anti-Inflammatory Constituents of the Rare Mushroom Calvatia nipponica in LPS-Stimulated RAW264.7 Macrophages. | Chem Biodivers | 2018 Sep | 29933520 |
| Fumonisin B<sub>1</sub> exposure increases Hsp70 expression in the lung and kidney of rats without inducing significant oxidative stress. | Acta Vet Hung | 2018 Sep | 30264617 |
| Mechanism and Implication of the Sorption of Perfluorooctanoic Acid by Varying Soil Size Fractions. | J Agric Food Chem | 2018 Oct 26 | 30240199 |
| Genomic characterization of cyanophage vB_AphaS-CL131 infecting filamentous diazotrophic cyanobacterium <i>Aphanizomenon flos-aquae</i> reveals novel insights into virus-bacterium interactions. | Appl Environ Microbiol | 2018 Oct 26 | 30367000 |
| Cytotoxic Tricycloalternarene Compounds from Endophyte <i>Alternaria</i> sp. W-1 Associated with <i>Laminaria japonica</i>. | Mar Drugs | 2018 Oct 23 | 30360544 |
| Food poisoning caused by scombroids: A case-control study. | J Infect Public Health | 2018 Oct 17 | 30342927 |
Targets
- General Function:
- Temperature-gated cation channel activity
- Specific Function:
- Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
- Gene Name:
- TRPA1
- Uniprot ID:
- O75762
- Molecular Weight:
- 127499.88 Da
References
- Nilius B, Prenen J, Owsianik G: Irritating channels: the case of TRPA1. J Physiol. 2011 Apr 1;589(Pt 7):1543-9. doi: 10.1113/jphysiol.2010.200717. Epub 2010 Nov 15. [21078588 ]
- General Function:
- Transcription regulatory region dna binding
- Specific Function:
- Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
- Gene Name:
- AHR
- Uniprot ID:
- P35869
- Molecular Weight:
- 96146.705 Da
- Mechanism of Action:
- Dibenzofurans bind the aryl hydrocarbon receptor, which increases its ability to activate transcription in the XRE promoter region. This alters the expression of a number of genes.
References
- Ni J, Pang ST, Yeh S: Differential retention of alpha-vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells. Prostate. 2007 Apr 1;67(5):463-71. [17252538 ]