Slotoxin
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Basic Info
| Common Name | Slotoxin(F04709) |
| 2D Structure | |
| Description | Slotoxin is a peptide from Centruroides noxius Hoffmann scorpion venom. It belongs to the short scorpion toxin superfamily. Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only ‘±-subunits (Kd = 1.5 nM). Unreversibly blocks the high conductance calcium-activated potassium channels composed of ‘±- and beta1-subunits. Unreversibly and weakly blocks the high conductance calcium-activated potassium channels composed of ‘±- and beta4-subunits. It shows no activity on other potassium channels. |
| FRCD ID | F04709 |
| CAS Number | 144026-79-9 |
| PubChem CID | 2734571 |
| Formula | C3F9O9S3Sc |
| IUPAC Name | scandium(3+);trifluoromethanesulfonate |
| InChI Key | HZXJVDYQRYYYOR-UHFFFAOYSA-K |
| InChI | InChI=1S/3CHF3O3S.Sc/c3*2-1(3,4)8(5,6)7;/h3*(H,5,6,7);/q;;;+3/p-3 |
| Canonical SMILES | C(F)(F)(F)S(=O)(=O)[O-].C(F)(F)(F)S(=O)(=O)[O-].C(F)(F)(F)S(=O)(=O)[O-].[Sc+3] |
| Isomeric SMILES | C(F)(F)(F)S(=O)(=O)[O-].C(F)(F)(F)S(=O)(=O)[O-].C(F)(F)(F)S(=O)(=O)[O-].[Sc+3] |
| Wikipedia | Slotoxin |
| Synonyms |
Scandium(III) trifluoromethanesulfonate
Scandium trifluoromethanesulfonate
Scandium(III) triflate
Scandium Triflate
SC(OTF)3
scandium(3+); trifluoromethanesulfonate
Trifluoromethanesulfonic acid scandium(III) salt
scandium(iii) trifluoromethanesulphonate
SCANDIUM TRIS(TRIFLUOROMETHANESULFONATE)
144026-79-9
|
| Classifies |
Animal Toxin
|
| Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
| Kingdom | Organic compounds |
| Superclass | Organic acids and derivatives |
| Class | Organic sulfonic acids and derivatives |
| Subclass | Organosulfonic acids and derivatives |
| Intermediate Tree Nodes | Alkanesulfonic acids and derivatives - Alkanesulfonic acids |
| Direct Parent | Trifluoromethanesulfonates |
| Alternative Parents | |
| Molecular Framework | Not available |
| Substituents | Trifluoromethanesulfonate - Methanesulfonate - Organosulfonic acid - Sulfonyl - Trihalomethane - Organic metal halide - Organic transition metal salt - Alkyl fluoride - Hydrocarbon derivative - Organic salt - Halomethane - Organic oxide - Organosulfur compound - Organofluoride - Organohalogen compound - Organic oxygen compound - Alkyl halide - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as trifluoromethanesulfonates. These are alkanesulfonic acids, that contain a sulfonate group that is substituted with a trifluoromethyl group. |
Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 492.146 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 18 |
| Rotatable Bond Count | 0 |
| Complexity | 145 |
| Monoisotopic Mass | 491.812 |
| Exact Mass | 491.812 |
| Formal Charge | 0 |
| Heavy Atom Count | 25 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 4 |
Targets
- General Function:
- Potassium channel regulator activity
- Specific Function:
- Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
- Gene Name:
- KCNMB1
- Uniprot ID:
- Q16558
- Molecular Weight:
- 21797.27 Da
- Mechanism of Action:
- Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha-subunits and irreversibly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta1- or beta4- subunits.
References
- Wikipedia. Slotoxin. Last Updated 13 May 2009. : http://en.wikipedia.org/wiki/Slotoxin
- General Function:
- Voltage-gated potassium channel activity
- Specific Function:
- Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
- Gene Name:
- KCNMA1
- Uniprot ID:
- Q12791
- Molecular Weight:
- 137558.115 Da
- Mechanism of Action:
- Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha-subunits and irreversibly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta1- or beta4- subunits.
References
- Wikipedia. Slotoxin. Last Updated 13 May 2009. : http://en.wikipedia.org/wiki/Slotoxin
- General Function:
- Potassium channel regulator activity
- Specific Function:
- Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
- Gene Name:
- KCNMB4
- Uniprot ID:
- Q86W47
- Molecular Weight:
- 23948.465 Da
- Mechanism of Action:
- Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha-subunits and irreversibly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta1- or beta4- subunits.
References
- Wikipedia. Slotoxin. Last Updated 13 May 2009. : http://en.wikipedia.org/wiki/Slotoxin