Cesium
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Basic Info
| Common Name | Cesium(F05173) |
| 2D Structure | |
| Description | Cesium (Caesium) is a soft, silvery-gold alkali metal with a melting point of 28°C (82°F). Cesium is used in various industries, from the oil industry as cesium formate in drilling fluid, atomic clocks, centrifugation fluids, and cesium vapor thermionic generators, which convert heat energy to electrical energy. |
| FRCD ID | F05173 |
| CAS Number | 7440-46-2 |
| PubChem CID | 5354618 |
| Formula | Cs |
| IUPAC Name | cesium |
| InChI Key | TVFDJXOCXUVLDH-UHFFFAOYSA-N |
| InChI | InChI=1S/Cs |
| Canonical SMILES | [Cs] |
| Isomeric SMILES | [Cs] |
| Wikipedia | Cesium |
| Synonyms |
Cesium (Metals Basis)
Cesium
Caesium
7440-46-2
Cesium-133
Cesium, elemental
UNII-1KSV9V4Y4I
HSDB 7040
EINECS 231-155-4
UN1407
|
| Classifies |
Metal
|
| Update Date | Nov 13, 2018 17:07 |
Chemical Taxonomy
| Kingdom | Inorganic compounds |
| Superclass | Homogeneous metal compounds |
| Class | Homogeneous alkali metal compounds |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Homogeneous alkali metal compounds |
| Alternative Parents | |
| Molecular Framework | Not available |
| Substituents | Homogeneous alkali metal |
| Description | This compound belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. |
Properties
| Property Name | Property Value |
|---|---|
| Molecular Weight | 132.905 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Complexity | 0 |
| Monoisotopic Mass | 132.905 |
| Exact Mass | 132.905 |
| Formal Charge | 0 |
| Heavy Atom Count | 1 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Isotope Atom Count | 0 |
| Covalently-Bonded Unit Count | 1 |
ADMET
| Model | Result | Probability |
|---|---|---|
| Absorption | ||
| Blood-Brain Barrier | BBB+ | 0.9733 |
| Human Intestinal Absorption | HIA+ | 0.9838 |
| Caco-2 Permeability | Caco2+ | 0.7354 |
| P-glycoprotein Substrate | Non-substrate | 0.8810 |
| P-glycoprotein Inhibitor | Non-inhibitor | 0.9787 |
| Non-inhibitor | 0.9858 | |
| Renal Organic Cation Transporter | Non-inhibitor | 0.9133 |
| Distribution | ||
| Subcellular localization | Lysosome | 0.5856 |
| Metabolism | ||
| CYP450 2C9 Substrate | Non-substrate | 0.8466 |
| CYP450 2D6 Substrate | Non-substrate | 0.8259 |
| CYP450 3A4 Substrate | Non-substrate | 0.8158 |
| CYP450 1A2 Inhibitor | Non-inhibitor | 0.8844 |
| CYP450 2C9 Inhibitor | Non-inhibitor | 0.9377 |
| CYP450 2D6 Inhibitor | Non-inhibitor | 0.9711 |
| CYP450 2C19 Inhibitor | Non-inhibitor | 0.9570 |
| CYP450 3A4 Inhibitor | Non-inhibitor | 0.9885 |
| CYP Inhibitory Promiscuity | Low CYP Inhibitory Promiscuity | 0.8820 |
| Excretion | ||
| Toxicity | ||
| Human Ether-a-go-go-Related Gene Inhibition | Weak inhibitor | 0.9547 |
| Non-inhibitor | 0.9746 | |
| AMES Toxicity | Non AMES toxic | 0.9633 |
| Carcinogens | Carcinogens | 0.6491 |
| Fish Toxicity | Low FHMT | 0.6181 |
| Tetrahymena Pyriformis Toxicity | Low TPT | 0.6631 |
| Honey Bee Toxicity | High HBT | 0.8278 |
| Biodegradation | Ready biodegradable | 0.7326 |
| Acute Oral Toxicity | III | 0.5846 |
| Carcinogenicity (Three-class) | Warning | 0.4769 |
| Model | Value | Unit |
|---|---|---|
| Absorption | ||
| Aqueous solubility | -1.0958 | LogS |
| Caco-2 Permeability | 1.6017 | LogPapp, cm/s |
| Distribution | ||
| Metabolism | ||
| Excretion | ||
| Toxicity | ||
| Rat Acute Toxicity | 2.0135 | LD50, mol/kg |
| Fish Toxicity | 1.5413 | pLC50, mg/L |
| Tetrahymena Pyriformis Toxicity | -0.7156 | pIGC50, ug/L |
References
| Title | Journal | Date | Pubmed ID |
|---|---|---|---|
| Model-based analyses of the cesium dynamics in the small mesotrophic reservoir,Pond 4. I. Estimating the inventories of and the fluxes among the pond's majorbiotic components. | J Environ Radioact | 2018 Sep | 29653692 |
| A double-tracer radioisotope approach to assess simultaneous bioaccumulation ofcaesium in the olive flounder Paralichthys olivaceus. | J Environ Radioact | 2018 Oct | 29803070 |
| Distribution and predictors of 20 toxic and essential metals in the umbilical cord blood of Chinese newborns. | Chemosphere | 2018 Nov | 30208542 |
| Stable and radioactive cesium: A review about distribution in the environment,uptake and translocation in plants, plant reactions and plants' potential forbioremediation. | Sci Total Environ | 2018 Mar 15 | 29122347 |
| Influence of diet in urinary levels of metals in a biomonitoring study of a childpopulation of the Valencian region (Spain). | Sci Total Environ | 2018 Mar 15 | 29054627 |
| Estimation of concentration of radionuclides in skeletal muscle from blood, basedon the data from abandoned animals in Fukushima. | Anim Sci J | 2018 Jun | 29696737 |
| Determination of cesium transfer factors by instrumental neutron activationanalysis. | J Environ Radioact | 2018 Jul | 29477642 |
| Internal Cs<sup>+</sup> inhibits root elongation in rice. | Plant Signal Behav | 2018 Feb 1 | 29336672 |
| Bio accumulation of radioactive caesium in marine mammals in the Baltic Sea -Reconstruction of a historical time series. | Sci Total Environ | 2018 Aug 1 | 29518725 |
| Pharmacological and gene regulation properties point to the SlHAK5 K<sup>+</sup> transporter as a system for high-affinity Cs<sup>+</sup> uptake in tomato plants. | Physiol Plant | 2018 Apr | 29055027 |
| Renal and hepatic effects following neonatal exposure to low doses of Bisphenol-A and <sup>137</sup>Cs. | Food Chem Toxicol | 2018 Apr | 29477810 |
| Trophic transfer of 134Cs in the Manila clam Ruditapes philippinarum. | J Environ Radioact | 2017 Oct | 28686945 |
| Simultaneous quantification of iodine and high valent metals via ICP-MS underacidic conditions in complex matrices. | Talanta | 2017 May 15 | 28340756 |
| Determination of Trace Metal Levels in the General Population of Korea. | Int J Environ Res Public Health | 2017 Jun 29 | 28661432 |
| Radioactive cesium and potassium in cattle living in the 'zone in preparation forthe lifting of the evacuation order' of the Fukushima nuclear accident. | Anim Sci J | 2017 Jul | 27878901 |
| A method for estimating radioactive cesium concentrations in cattle blood usingurine samples. | Anim Sci J | 2017 Dec | 28776878 |
| Evaluation of a method for removing cesium and reducing the volume of leaf litterfrom broad-leaved trees contaminated by the Fukushima Daiichi nuclear accidentduring the Great East Japan Earthquake. | Chemosphere | 2017 Apr | 28108022 |
| Activity of cesium 137Cs and potassium content in new potatoes imported to Poland | Rocz Panstw Zakl Hig | 2017 | 28895674 |
| Exposure to low doses of <sup>137</sup>cesium and nicotine during postnatal development modifies anxiety levels, learning, and spatial memory performance in mice. | Food Chem Toxicol | 2016 Nov | 27590783 |
| The Current Limits for Radionuclides in Food in Japan. | Health Phys | 2016 Nov | 27682906 |
Targets
- General Function:
- Voltage-gated potassium channel activity
- Specific Function:
- Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
- Gene Name:
- KCNH3
- Uniprot ID:
- Q9ULD8
- Molecular Weight:
- 117127.74 Da
References
- Becchetti A, De Fusco M, Crociani O, Cherubini A, Restano-Cassulini R, Lecchi M, Masi A, Arcangeli A, Casari G, Wanke E: The functional properties of the human ether-a-go-go-like (HELK2) K+ channel. Eur J Neurosci. 2002 Aug;16(3):415-28. [12193184 ]