FRCD

Methylguanidine is a uremic toxin. Uremic toxins can be subdivided into three major groups based upon their chemical and physical characteristics: 1) small, water-soluble, non-protein-bound compounds, such as urea; 2) small, lipid-soluble and/or protein-bound compounds, such as the phenols and 3) larger so-called middle-molecules, such as beta2-microglobulin. Chronic exposure of uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease.
Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibits anti-inflammatory effects. Methylguanidine is synthesized from creatinine concomitant with the synthesis of hydrogen peroxide from endogenous substrates in peroxisomes. Recent evidence suggests that methylguanidine significantly inhibits iNOS activity and TNF- release. This means that methylguandine can attenuate the degree of inflammation and tissue damage associated with endotoxic shock.

2-methylguanidine

CHJJGSNFBQVOTG-UHFFFAOYSA-N

InChI=1S/C2H7N3/c1-5-2(3)4/h1H3,(H4,3,4,5)

CN=C(N)N

CN=C(N)N

        
            1-methylguanidine
        
            METHYLGUANIDINE
        
            N-Methylguanidine
        
            Methylguanidin
        
            Guanidine, methyl-
        
            Monomethylguanidine
        
            Monomethyl guanidin
        
            471-29-4
        
            N1-Methylguanidine
        
            Methylguanidin [German]
        

                

                  
                    Predicted: Pollutant
                  

                
        

• Hydrocarbon derivatives
• Organopnictogen compounds
• Imines
• Carboximidamides