FRCD

4-Hydroxynonenal is a uremic toxin. Uremic toxins can be subdivided into three major groups based upon their chemical and physical characteristics: 1) small, water-soluble, non-protein-bound compounds, such as urea; 2) small, lipid-soluble and/or protein-bound compounds, such as the phenols and 3) larger so-called middle-molecules, such as beta2-microglobulin. Chronic exposure of uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease.
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. glutathione S-transferases (GSTs) can modulate the intracellular concentrations of HNE by affecting its generation during lipid peroxidation by reducing hydroperoxides and also by converting it into a glutathione conjugate. Overexpression of the Alpha class GSTs in cells leads to lower steady-state levels of HNE, and these cells acquire resistance to apoptosis induced by lipid peroxidation-causing agents such as H(2)O(2), UVA, superoxide anion, and pro-oxidant xenobiotics, suggesting that signaling for apoptosis by these agents is transduced through HNE. Cells with the capacity to exclude HNE from the intracellular environment at a faster rate are relatively more resistant to apoptosis caused by H(2)O(2), UVA, superoxide anion, and pro-oxidant xenobiotics as well as by HNE, suggesting that HNE may be a common denominator in mechanisms of apoptosis caused by oxidative stress. Transfection of adherent cells with HNE-metabolizing GSTs leads to transformation of these cells due to depletion of HNE. (A3295).

(E)-4-hydroxynon-2-enal

JVJFIQYAHPMBBX-FNORWQNLSA-N

InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+

CCCCCC(C=CC=O)O

CCCCCC(/C=C/C=O)O

        
            4-Hydroxynonenal
        
            4-Hydroxy-2-nonenal
        
            4-hydroxynon-2-enal
        
            trans-4-Hydroxy-2-nonenal
        
            4-Hydroxy-2,3-nonenal
        
            4-HNE
        
            75899-68-2
        
            4-hydroxy-2E-nonenal
        
            CCRIS 1781
        
            CCRIS 9028
        

                

                  
                    Predicted: Pesticide
                  

                
        

• Hydrocarbon derivatives
• Organic oxides
• Secondary alcohols
• Enals
• Medium-chain aldehydes