Gamma-aminobutyric acid receptor subunit rho-3

NameGamma-aminobutyric acid receptor subunit rho-3
SynonymsGABA(A) receptor subunit rho-3 GABA(C) receptor
Gene NameGABRR3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017160|Gamma-aminobutyric acid receptor subunit rho-3
MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQK
YEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLS
FPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITV
SAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFS
ASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARV
SLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEER
KQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSS
RIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV
Number of residues467
Molecular Weight54271.1
Theoretical pI8.26
GO Classification
Functions
    extracellular ligand-gated ion channel activity
chloride channel activity
GABA-A receptor activity
Processes
    transmembrane transport
ion transmembrane transport
gamma-aminobutyric acid signaling pathway
synaptic transmission
Components
    chloride channel complex
postsynaptic membrane
plasma membrane
cell junction
General FunctionGaba-a receptor activity
Specific FunctionGABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Transmembrane Regions267-287 300-320 332-352 447-467
GenBank Protein ID
UniProtKB IDA8MPY1
UniProtKB Entry NameGBRR3_HUMAN
Cellular LocationCell junction
Gene sequence
>lcl|BSEQ0017161|Gamma-aminobutyric acid receptor subunit rho-3 (GABRR3)
ATGGTCCTGGCTTTCCAGTTAGTCTCCTTCACCTACATCTGGATCATATTGAAACCAAAT
GTTTGTGCTGCTTCTAACATCAAGATGACACACCAGCGGTGCTCCTCTTCAATGAAACAA
ACCTGCAAACAAGAAACTAGAATGAAGAAAGATGACAGTACCAAAGCGCGGCCTCAGAAA
TATGAGCAACTTCTCCATATAGAGGACAACGATTTCGCAATGAGACCTGGATTTGGAGGG
TCTCCAGTGCCAGTAGGTATAGATGTCCATGTTGAAAGCATTGACAGCATTTCAGAGACT
AACATGGACTTTACAATGACTTTTTATCTCAGGCATTACTGGAAAGACGAGAGGCTCTCC
TTTCCTAGCACAGCAAACAAAAGCATGACATTTGATCATAGATTGACCAGAAAGATCTGG
GTGCCTGATATCTTTTTTGTCCACTCTAAAAGATCCTTCATCCATGATACAACTATGGAG
AATATCATGCTGCGCGTACACCCTGATGGAAACGTCCTCCTAAGTCTCAGGATAACGGTT
TCGGCCATGTGCTTTATGGATTTCAGCAGGTTTCCTCTTGACACTCAAAATTGTTCTCTT
GAACTGGAAAGCTATGCCTACAATGAGGATGACCTAATGCTATACTGGAAACACGGAAAC
AAGTCCTTAAATACTGAAGAACATATGTCCCTTTCTCAGTTCTTCATTGAAGACTTCAGT
GCATCTAGTGGATTAGCTTTCTATAGCAGCACAGGTTGGTACAATAGGCTTTTCATCAAC
TTTGTGCTAAGGAGGCATGTTTTCTTCTTTGTGCTGCAAACCTATTTCCCAGCCATATTG
ATGGTGATGCTTTCATGGGTTTCATTTTGGATTGACCGAAGAGCTGTTCCTGCAAGAGTT
TCCCTGGGAATCACCACAGTGCTGACCATGTCCACAATCATCACTGCTGTGAGCGCCTCC
ATGCCCCAGGTGTCCTACCTCAAGGCTGTGGATGTGTACCTGTGGGTCAGCTCCCTCTTT
GTGTTCCTGTCAGTCATTGAGTATGCAGCTGTGAACTACCTCACCACAGTGGAAGAGCGG
AAACAATTCAAGAAGACAGGAAAGATTTCTAGGATGTACAATATTGATGCAGTTCAAGCT
ATGGCCTTTGATGGTTGTTACCATGACAGCGAGATTGACATGGACCAGACTTCCCTCTCT
CTAAACTCAGAAGACTTCATGAGAAGAAAATCGATATGCAGCCCCAGCACCGATTCATCT
CGGATAAAGAGAAGAAAATCCCTAGGAGGACATGTTGGTAGAATCATTCTGGAAAACAAC
CATGTCATTGACACCTATTCTAGGATTTTATTCCCCATTGTGTATATTTTATTTAATTTG
TTTTACTGGGGTGTATATGTATGA
GenBank Gene IDAC026100
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:17969
Chromosome Location3
Locus3q11.2
References
  1. Bailey ME, Albrecht BE, Johnson KJ, Darlison MG: Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. Biochim Biophys Acta. 1999 Oct 28;1447(2-3):307-12.[10542332 ]
  2. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8.[16641997 ]

Related FRC

FRCD ID Name Exact Mass Structure




F03291



Toxaphene


411.774




F03293



Tetrachloroethylene


165.822




F03294



Heptachlor


373.3




F03299



3,3'-Dichlorobenzidine


253.126




F03300



Endrin


380.895




F03303



Pentachlorophenol


266.323




F03324



Toluene


92.141




F03332



1,1-Dichloroethene


96.938




F03336



1,2-Dichloroethane


98.954




F03337



2,4,6-Trichlorophenol


197.439




F03341



Hexachlorobenzene


284.766




F03344



1,1,1-Trichloroethane


133.396




F03349



Chlorobenzene


112.556




F03360



1,2,3-Trichlorobenzene


181.44




F03370



Chlorpyrifos


350.575




F03381



Chlordecone


490.609




F03386



Dicofol


370.475




F03388



1,1,2,2-Tetrachloroethane


167.838




F03395



1,4-Dichlorobenzene


146.998




F03396



1,1-Dichloroethane


98.954




F03400



Hexachlorocyclopentadiene


272.755




F03405



1,2-Dichlorobenzene


146.998




F03756



Methiochlor


377.766




F03757



Chlorbenzylate


325.185




F03886



1,3,5-Trichlorobenzene


181.44




F03917



Mirex


545.51




F04038



Telodrin


411.73




F04039



Isodrin


364.896




F04769



Diazepam


284.74




F04789



Anisatin


328.317




F04791



Cicutoxin


258.361




F04797



Oenanthotoxin


258.361




F04973



Aflatrem


501.667




F04979



Penitrem A


634.21




F04980



Penitrem B


583.769




F04987



Fumitremorgin A


579.694




F04988



Fumitremorgin B


479.577




F04989



Fumitremorgin C


379.46




F04993



Paspalinine


433.548




F05005



Janthitrem B


585.785




F05006



Janthitrem C


569.786




F05007



Janthitrem E


603.8




F05008



Janthitrem F


645.837




F05009



Janthitrem G


629.838




F05017



Paspalitrem A


501.667




F05018



Paspalicine


417.549




F05019



Paxilline


435.564




F05020



Verrucosidin


416.514




F05021



Verruculogen


511.575




F05465



Lormetazepam


335.184




F03280



Trichloroethylene


131.38




F03424



1,2,4-Trichlorobenzene


181.44




F04981



Penitrem C


602.212




F03275



Chloroform


119.369




F03276



Clofenotane


354.476




F03281



Dieldrin


380.895




F03283



Chlordane


409.758




F03285



Hexachlorobutadiene


260.744