Copper transport protein ATOX1


NameCopper transport protein ATOX1
SynonymsHAH1 Metal transport protein ATX1
Gene NameATOX1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016908|Copper transport protein ATOX1
MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGK
TVSYLGLE
Number of residues68
Molecular Weight7401.575
Theoretical pI7.35
GO Classification
Functions
    copper chaperone activity
    copper ion transmembrane transporter activity
    copper-dependent protein binding
    metallochaperone activity
    copper ion binding
Processes
    cellular copper ion homeostasis
    intracellular copper ion transport
    response to oxidative stress
    copper ion transport
    response to reactive oxygen species
Components
    cytosol
General FunctionMetallochaperone activity
Specific FunctionBinds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDO00244
UniProtKB Entry NameATOX1_HUMAN
Cellular Location
Gene sequence
>lcl|BSEQ0016909|Copper transport protein ATOX1 (ATOX1)
ATGCCGAAGCACGAGTTCTCTGTGGACATGACCTGTGGAGGCTGTGCTGAAGCTGTCTCT
CGGGTCCTCAATAAGCTTGGAGGAGTTAAGTATGACATTGACCTGCCCAACAAGAAGGTC
TGCATTGAATCTGAGCACAGCATGGACACTCTGCTTGCAACCCTGAAGAAAACAGGAAAG
ACTGTTTCCTACCTTGGCCTTGAGTAG
GenBank Gene IDU70660
GeneCard IDNone
GenAtlas IDATOX1
HGNC IDHGNC:798
Chromosome Location5
Locus5q32
References
  1. Klomp LW, Lin SJ, Yuan DS, Klausner RD, Culotta VC, Gitlin JD: Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. J Biol Chem. 1997 Apr 4;272(14):9221-6.[9083055 ]
  2. Liu PC, Koeller DM, Kaler SG: Genomic organization of ATOX1, a human copper chaperone. BMC Genet. 2003 Feb 5;4:4.[12594858 ]
  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16.[19608861 ]
  4. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17.[21269460 ]
  5. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22.[24275569 ]
  6. Wernimont AK, Huffman DL, Lamb AL, O'Halloran TV, Rosenzweig AC: Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins. Nat Struct Biol. 2000 Sep;7(9):766-71.[10966647 ]
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