Cocaine esterase
Name | Cocaine esterase |
---|---|
Synonyms | 3.1.1.84 Carboxylesterase 2 CE-2 hCE-2 ICE Methylumbelliferyl-acetate deacetylase 2 |
Gene Name | CES2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008563|Cocaine esterase MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLG IPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMS EDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLG VLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVS PISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEI LAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQ KEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPA LQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEE EQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKK ALPQKIQELEEPEERHTEL |
Number of residues | 559 |
Molecular Weight | 61806.41 |
Theoretical pI | None |
GO Classification |
Functions
carboxylic ester hydrolase activity methylumbelliferyl-acetate deacetylase activity Processes
small molecule metabolic process xenobiotic metabolic process catabolic process Components
endoplasmic reticulum extracellular space endoplasmic reticulum lumen |
General Function | Methylumbelliferyl-acetate deacetylase activity |
Specific Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. |
Transmembrane Regions | |
GenBank Protein ID | |
UniProtKB ID | O00748 |
UniProtKB Entry Name | EST2_HUMAN |
Cellular Location | Endoplasmic reticulum lumen |
Gene sequence | >lcl|BSEQ0013276|Cocaine esterase (CES2) ATGACTGCTCAGTCCCGCTCTCCTACCACACCCACCTTTCCCGGCCCAAGCCAGCGCACC CCGCTGACTCCCTGCCCAGTCCAAACTCCAAGGCTGGGCAAGGCACTGATCCACTGCTGG ACAGACCCGGGGCAGCCTCTGGGTGAACAGCAGCGTGTCCGCCGGCAGCGAACCGAGACC AGCGAGCCGACCATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGG CTTCTGCTGCTTCTTGTCCGGGGCCAGGGCCAGGACTCAGCCAGTCCCATCCGGACCACA CACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAA ACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCT GAGCCCCCTGAATCTTGGAGTGGTGTGAGGGATGGAACCACCCATCCGGCCATGTGTCTA CAGGACCTCACCGCAGTGGAGTCAGAGTTTCTTAGCCAGTTCAACATGACCTTCCCTTCC GACTCCATGTCTGAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAA GGCTCTAACCTGCCGGTGATGGTGTGGATCCACGGTGGTGCGCTTGTTTTTGGCATGGCT TCCTTGTATGATGGTTCCATGCTGGCTGCCTTGGAGAACGTGGTGGTGGTCATCATCCAG TACCGCCTGGGTGTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGG GGCTACCTGGACCAAGTGGCTGCACTACGCTGGGTCCAGCAGAATATCGCCCACTTTGGA GGCAACCCTGACCGTGTCACCATTTTTGGCGAGTCTGCGGGTGGCACGAGTGTGTCTTCG CTTGTTGTGTCCCCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTG GCCCTCCTGCCCGGCCTCATTGCCAGCTCAGCTGATGTCATCTCCACGGTGGTGGCCAAC CTGTCTGCCTGTGACCAAGTTGACTCTGAGGCCCTGGTGGGCTGCCTGCGGGGCAAGAGT AAAGAGGAGATTCTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGG GTCTTCCTGCCCAGGCACCCCCAGGAGCTGCTGGCCTCTGCCGACTTTCAGCCTGTCCCT AGCATTGTTGGTGTCAACAACAATGAATTCGGCTGGCTCATCCCCAAGGTCATGAGGATC TATGATACCCAGAAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTA ACGCTGCTGATGTTGCCTCCTACATTTGGTGACCTGCTGAGGGAGGAGTACATTGGGGAC AATGGGGATCCCCAGACCCTCCAAGCGCAGTTCCAGGAGATGATGGCGGACTCCATGTTT GTGATCCCTGCACTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTAC GAGTTCCAGCATCAGCCCAGCTGGCTCAAGAACATCAGGCCACCGCACATGAAGGCAGAC CATGGTGATGAGCTTCCTTTTGTTTTCAGAAGTTTCTTTGGGGGCAACTACATTAAATTC ACTGAGGAAGAGGAGCAGCTAAGCAGGAAGATGATGAAGTACTGGGCCAACTTTGCGAGA AATGGGAACCCCAATGGCGAGGGTCTGCCACACTGGCCGCTGTTCGACCAGGAGGAGCAA TACCTGCAGCTGAACCTACAGCCTGCGGTGGGCCGGGCTCTGAAGGCCCACAGGCTCCAG TTCTGGAAGAAGGCGCTGCCCCAAAAGATCCAGGAGCTCGAGGAGCCTGAAGAGAGACAC ACAGAGCTGTAG |
GenBank Gene ID | |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:1864 |
Chromosome Location | 16 |
Locus | None |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Diacetyl |
86.09 |
||
Benzophenone |
182.222 |
||
Quinone |
108.096 |
||
1,2-Naphthoquinone |
158.156 |