DNA-directed RNA polymerases I and III subunit RPAC1

NameDNA-directed RNA polymerases I and III subunit RPAC1
SynonymsAC40 DNA-directed RNA polymerase I subunit C DNA-directed RNA polymerases I and III 40 kDa polypeptide POLR1E RPA39 RPA40 RPC40
Gene NamePOLR1C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009193|DNA-directed RNA polymerases I and III subunit RPAC1
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD
Number of residues346
Molecular Weight39249.375
Theoretical pINone
GO Classification
Functions
    DNA binding
DNA-directed RNA polymerase activity
Processes
    innate immune response
transcription from RNA polymerase III promoter
negative regulation of gene expression, epigenetic
transcription initiation from RNA polymerase I promoter
regulation of gene expression, epigenetic
positive regulation of type I interferon production
termination of RNA polymerase I transcription
termination of RNA polymerase III transcription
gene expression
transcription elongation from RNA polymerase I promoter
transcription elongation from RNA polymerase III promoter
transcription from RNA polymerase I promoter
Components
    DNA-directed RNA polymerase I complex
DNA-directed RNA polymerase III complex
cytosol
nucleoplasm
General FunctionDna-directed rna polymerase activity
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Transmembrane Regions
GenBank Protein ID
UniProtKB IDO15160
UniProtKB Entry NameRPAC1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021441|DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C)
ATGGCGGCTTCTCAGGCGGTGGAGGAAATGCGGAGCCGCGTGGTTCTGGGGGAGTTTGGG
GTTCGCAATGTCCATACTACTGACTTTCCCGGTAACTATTCCGGTTATGATGATGCCTGG
GACCAGGACCGCTTCGAGAAGAATTTCCGTGTGGATGTAGTACACATGGATGAAAACTCA
CTGGAGTTTGACATGGTGGGAATTGACGCAGCCATTGCCAATGCTTTTCGACGAATTCTG
CTAGCTGAGGTGCCAACTATGGCTGTGGAGAAGGTCCTGGTGTACAATAATACATCCATT
GTTCAGGATGAGATTCTTGCTCACCGTCTGGGGCTCATTCCCATTCATGCTGATCCCCGT
CTTTTTGAGTATCGGAACCAAGGAGATGAAGAAGGCACAGAGATAGATACTCTACAGTTT
CGTCTCCAGGTCAGATGCACTCGGAACCCCCATGCTGCTAAAGATTCCTCTGACCCCAAC
GAACTGTACGTGAACCACAAAGTGTATACCAGGCATATGACATGGATCCCCCTGGGGAAC
CAGGCTGATCTCTTTCCAGAGGGCACTATCCGACCAGTGCATGATGATATCCTCATCGCT
CAGCTGCGGCCTGGCCAAGAAATTGACCTGCTCATGCACTGTGTCAAGGGCATTGGCAAA
GATCATGCCAAGTTTTCACCAGTGGCAACAGCCAGTTACAGGCTCCTGCCAGACATCACC
CTGCTTGAGCCCGTGGAAGGGGAGGCAGCTGAGGAGTTGAGCAGGTGCTTCTCACCTGGT
GTTATTGAGGTGCAGGAAGTCCAAGGTAAAAAGGTGGCCAGAGTTGCCAACCCCCGGCTG
GATACCTTCAGCAGAGAAATCTTCCGGAATGAGAAGCTAAAGAAGGTTGTGAGGCTTGCC
CGGGTTCGAGATCATTATATCTTCTCTGTTGAGTCAACGGGGGTGTTGCCACCAGATGTG
CTGGTGAGTGAAGCCATCAAAGTACTGATGGGGAAGTGCCGGCGCTTCTTGGATGAACTA
GATGCGGTTCAGATGGACTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:20194
Chromosome Location6
LocusNone
References
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