Histone deacetylase 3

NameHistone deacetylase 3
Synonyms3.5.1.98 HD3 RPD3-2 SMAP45
Gene NameHDAC3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004649|Histone deacetylase 3
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
Number of residues428
Molecular Weight48847.385
Theoretical pI4.79
GO Classification
Functions
    transcription factor binding
histone deacetylase activity
enzyme binding
histone deacetylase binding
transcription corepressor activity
NAD-dependent histone deacetylase activity (H3-K14 specific)
NF-kappaB binding
protein deacetylase activity
chromatin DNA binding
cyclin binding
chromatin binding
Processes
    neurotrophin TRK receptor signaling pathway
negative regulation of cardiac muscle cell differentiation
negative regulation of transcription, DNA-templated
regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
circadian rhythm
negative regulation of cell cycle
circadian regulation of gene expression
negative regulation of transcription from RNA polymerase II promoter
cellular response to fluid shear stress
small molecule metabolic process
cellular lipid metabolic process
chromatin modification
regulation of multicellular organism growth
regulation of protein stability
protein deacetylation
transcription, DNA-templated
negative regulation of JNK cascade
positive regulation of protein phosphorylation
negative regulation of nucleic acid-templated transcription
positive regulation of TOR signaling
spindle assembly
positive regulation of transcription factor import into nucleus
Notch signaling pathway
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
chromatin organization
Components
    transcriptional repressor complex
histone deacetylase complex
Golgi apparatus
cytosol
nucleoplasm
cytoplasm
nucleus
plasma membrane
spindle microtubule
General FunctionTranscription factor binding
Specific FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Transmembrane Regions
GenBank Protein ID2326173
UniProtKB IDO15379
UniProtKB Entry NameHDAC3_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021323|Histone deacetylase 3 (HDAC3)
ATGGCCAAGACCGTGGCCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACGGAGCT
GGACACCCTATGAAGCCCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGT
CTCTATAAGAAGATGATCGTCTTCAAGCCATACCAGGCCTCCCAACATGACATGTGCCGC
TTCCACTCCGAGGACTACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGC
TTCACCAAGAGTCTTAATGCCTTCAACGTAGGCGATGACTGCCCAGTGTTTCCCGGGCTC
TTTGAGTTCTGCTCGCGTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAAC
AAGATCTGTGATATTGCCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAG
GCCTCTGGCTTCTGCTATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAAGTAC
CACCCTCGGGTGCTCTACATTGACATTGACATCCACCATGGTGACGGGGTTCAAGAAGCT
TTCTACCTCACTGACCGGGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTC
CCTGGCACAGGTGACATGTATGAAGTCGGGGCAGAGAGTGGCCGCTACTACTGTCTGAAC
GTGCCCCTGCGGGATGGCATTGATGACCAGAGTTACAAGCACCTTTTCCAGCCGGTTATC
AACCAGGTAGTGGACTTCTACCAACCCACGTGCATTGTGCTCCAGTGTGGAGCTGACTCT
CTGGGCTGTGATCGATTGGGCTGCTTTAACCTCAGCATCCGAGGGCATGGGGAATGCGTT
GAATATGTCAAGAGCTTCAATATCCCTCTACTCGTGCTGGGTGGTGGTGGTTATACTGTC
CGAAATGTTGCCCGCTGCTGGACATATGAGACATCGCTGCTGGTAGAAGAGGCCATTAGT
GAGGAGCTTCCCTATAGTGAATACTTCGAGTACTTTGCCCCAGACTTCACACTTCATCCA
GATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAGTATCTGGACCAGATCCGCCAG
ACAATCTTTGAAAACCTGAAGATGCTGAACCATGCACCTAGTGTCCAGATTCATGACGTG
CCTGCAGACCTCCTGACCTATGACAGGACTGATGAGGCTGATGCAGAGGAGAGGGGTCCT
GAGGAGAACTATAGCAGGCCAGAGGCACCCAATGAGTTCTATGATGGAGACCATGACAAT
GACAAGGAAAGCGATGTGGAGATTTAA
GenBank Gene IDU66914
GeneCard IDNone
GenAtlas IDHDAC3
HGNC IDHGNC:4854
Chromosome Location5
Locus5q31
References
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FRCD ID Name Exact Mass Structure




F05037



Captan


300.578