Intermediate conductance calcium-activated potassium channel protein 4
Name | Intermediate conductance calcium-activated potassium channel protein 4 |
---|---|
Synonyms | IK1 IKCA1 KCa3.1 KCA4 Putative Gardos channel SK4 |
Gene Name | KCNN4 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0016086|Intermediate conductance calcium-activated potassium channel protein 4 MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP EPSQQSK |
Number of residues | 427 |
Molecular Weight | 47695.12 |
Theoretical pI | 10.39 |
GO Classification |
Functions
calcium-activated potassium channel activity protein phosphatase binding calmodulin binding Intermediate conductance calcium-activated potassium channel activity Processes
synaptic transmission positive regulation of protein secretion potassium ion export saliva secretion immune system process positive regulation of T cell receptor signaling pathway calcium ion transport potassium ion transmembrane transport potassium ion transport phospholipid translocation defense response cell volume homeostasis stabilization of membrane potential Components
neuronal cell body voltage-gated potassium channel complex basolateral plasma membrane membrane raft apical plasma membrane plasma membrane |
General Function | Protein phosphatase binding |
Specific Function | Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614). |
Transmembrane Regions | 29-49 59-79 108-128 143-163 207-227 265-285 |
GenBank Protein ID | 2584866 |
UniProtKB ID | O15554 |
UniProtKB Entry Name | KCNN4_HUMAN |
Cellular Location | Cell membrane |
Gene sequence | >lcl|BSEQ0016087|Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4) ATGGGCGGGGATCTGGTGCTTGGCCTGGGGGCCTTGAGACGCCGAAAGCGCTTGCTGGAG CAGGAGAAGTCTCTGGCCGGCTGGGCACTGGTGCTGGCAGGAACTGGCATTGGACTCATG GTGCTGCATGCAGAGATGCTGTGGTTCGGGGGGTGCTCGTGGGCGCTCTACCTGTTCCTG GTTAAATGCACGATCAGCATTTCCACCTTCTTACTCCTCTGCCTCATCGTGGCCTTTCAT GCCAAAGAGGTCCAGCTGTTCATGACCGACAACGGGCTGCGGGACTGGCGCGTGGCGCTG ACCGGGCGGCAGGCGGCGCAGATCGTGCTGGAGCTGGTGGTGTGTGGGCTGCACCCGGCG CCCGTGCGGGGCCCGCCGTGCGTGCAGGATTTAGGGGCGCCGCTGACCTCCCCGCAGCCC TGGCCGGGATTCCTGGGCCAAGGGGAAGCGCTGCTGTCCCTGGCCATGCTGCTGCGTCTC TACCTGGTGCCCCGCGCCGTGCTCCTGCGCAGCGGCGTCCTGCTCAACGCTTCCTACCGC AGCATCGGCGCTCTCAATCAAGTCCGCTTCCGCCACTGGTTCGTGGCCAAGCTTTACATG AACACGCACCCTGGCCGCCTGCTGCTCGGCCTCACGCTTGGCCTCTGGCTGACCACCGCC TGGGTGCTGTCCGTGGCCGAGAGGCAGGCTGTTAATGCCACTGGGCACCTTTCAGACACA CTTTGGCTGATCCCCATCACATTCCTGACCATCGGCTATGGTGACGTGGTGCCGGGCACC ATGTGGGGCAAGATCGTCTGCCTGTGCACTGGAGTCATGGGTGTCTGCTGCACAGCCCTG CTGGTGGCCGTGGTGGCCCGGAAGCTGGAGTTTAACAAGGCAGAGAAGCACGTGCACAAC TTCATGATGGATATCCAGTATACCAAAGAGATGAAGGAGTCCGCTGCCCGAGTGCTACAA GAAGCCTGGATGTTCTACAAACATACTCGCAGGAAGGAGTCTCATGCTGCCCGCAGGCAT CAGCGCAAGCTGCTGGCCGCCATCAACGCGTTCCGCCAGGTGCGGCTGAAACACCGGAAG CTCCGGGAACAAGTGAACTCCATGGTGGACATCTCCAAGATGCACATGATCCTGTATGAC CTGCAGCAGAATCTGAGCAGCTCACACCGGGCCCTGGAGAAACAGATTGACACGCTGGCG GGGAAGCTGGATGCCCTGACTGAGCTGCTTAGCACTGCCCTGGGGCCGAGGCAGCTTCCA GAACCCAGCCAGCAGTCCAAGTAG |
GenBank Gene ID | AF000972 |
GeneCard ID | None |
GenAtlas ID | KCNN4 |
HGNC ID | HGNC:6293 |
Chromosome Location | 19 |
Locus | 19q13.2 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Clotrimazole |
344.842 |
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Charybdotoxin |
4324.011 |