Kinesin-like protein KIF1C

NameKinesin-like protein KIF1C
SynonymsKIAA0706
Gene NameKIF1C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009152|Kinesin-like protein KIF1C
MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHT
STEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVP
QLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQD
LSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEK
VSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPY
RDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNA
RLIRELQEEVARLRELLMAQGLSASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHN
GELEPSFSPNTESQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMG
VAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQVDMDIKLTGQFIR
EQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHP
EQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEE
ADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRR
APRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMR
ELCRTYGKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKL
TGILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPEGSEAAE
EAAPSDRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSGGRGG
GLRRPPARFVPPHDCKLRFPFKSNPQHRESWPGMGSGEAPTPLQPPEEVTPHPATPARRP
PSPRRSHHPRRNSLDGGGRSRGAGSAQPEPQHFQPKKHNSYPQPPQPYPAQRPPGPRYPP
YTTPPRMRRQRSAPDLKESGAAV
Number of residues1103
Molecular Weight122945.52
Theoretical pINone
GO Classification
Functions
    poly(A) RNA binding
ATP-dependent microtubule motor activity, plus-end-directed
ATP binding
motor activity
Processes
    cytoskeleton-dependent intracellular transport
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
Components
    Golgi apparatus
kinesin complex
microtubule
endoplasmic reticulum
General FunctionPoly(a) rna binding
Specific FunctionMotor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDO43896
UniProtKB Entry NameKIF1C_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019725|Kinesin-like protein KIF1C (KIF1C)
ATGGCTGGTGCCTCGGTGAAAGTGGCAGTGAGGGTTCGGCCCTTTAACGCCCGTGAGACC
AGCCAGGATGCCAAGTGTGTGGTCAGCATGCAGGGCAACACCACCTCCATCATCAATCCT
AAACAGAGCAAGGATGCCCCCAAAAGCTTCACCTTTGACTACTCCTACTGGTCACACACT
TCGACGGAGGACCCCCAGTTTGCATCTCAGCAGCAAGTGTATCGGGACATTGGAGAAGAG
ATGCTGCTCCACGCCTTTGAAGGCTACAACGTGTGCATCTTTGCCTATGGGCAGACCGGG
GCTGGGAAATCCTATACCATGATGGGGCGACAGGAGCCAGGGCAGCAGGGCATCGTGCCC
CAGCTCTGTGAGGACCTCTTCTCTCGCGTTAGTGAGAACCAGAGTGCTCAGCTATCCTAC
TCTGTGGAGGTGAGCTATATGGAGATCTACTGTGAGCGGGTACGAGACCTCTTGAACCCC
AAGAGTCGGGGTTCTCTGCGGGTCCGGGAGCACCCCATCCTGGGCCCGTACGTGCAGGAC
CTGTCCAAATTGGCTGTGACCTCCTACGCAGACATTGCTGACCTCATGGACTGTGGAAAT
AAAGCACGGACTGTGGCTGCCACCAACATGAATGAGACCAGCAGCCGTTCCCATGCCGTC
TTTACCATCGTCTTCACACAGCGCTGCCATGACCAGCTCACGGGGCTGGACTCGGAGAAG
GTCAGTAAGATCAGTTTGGTGGACCTTGCTGGGAGTGAGCGAGCCGACTCCTCAGGGGCC
CGGGGCATGCGCCTGAAGGAAGGAGCCAACATCAATAAGTCCCTGACTACACTAGGGAAA
GTGATCTCGGCCCTTGCAGATATGCAATCAAAGAAGCGAAAGTCGGATTTTATCCCCTAC
AGGGACTCTGTGCTCACCTGGCTGCTCAAGGAAAATTTGGGGGGGAACTCACGCACAGCC
ATGATTGCAGCCCTGAGCCCTGCTGACATCAATTACGAGGAGACTCTCAGCACCCTCAGG
TATGCTGACCGCACCAAGCAAATCCGCTGCAATGCCATCATCAACGAGGACCCTAATGCC
CGGCTGATTAGAGAGCTGCAGGAGGAAGTAGCCCGGCTGCGGGAACTGCTGATGGCTCAG
GGACTGTCAGCCTCTGCTCTGGAAGGCCTGAAGACGGAAGAAGGGAGTGTCAGAGGCGCC
CTGCCAGCTGTGTCATCTCCCCCAGCTCCAGTTTCACCCTCATCACCCACCACACATAAT
GGGGAGCTGGAGCCGTCATTCTCCCCCAACACGGAGTCCCAGATTGGGCCTGAGGAAGCC
ATGGAGAGGCTGCAGGAGACAGAGAAGATTATAGCTGAGCTGAACGAGACATGGGAGGAG
AAGCTACGCAAGACAGAAGCCCTGAGGATGGAGAGAGAAGCATTGCTGGCTGAGATGGGG
GTGGCCGTCCGGGAGGATGGGGGAACTGTGGGCGTCTTCTCTCCAAAGAAGACTCCCCAC
CTGGTGAACCTGAACGAAGACCCTCTGATGTCTGAGTGTCTGCTCTACCACATCAAAGAT
GGCGTCACCAGGGTCGGCCAAGTAGATATGGACATCAAGCTGACCGGACAGTTCATTCGG
GAGCAACACTGTCTGTTCCGGAGCATCCCCCAGCCAGATGGAGAAGTGGTGGTCACTCTG
GAGCCTTGTGAAGGAGCTGAGACATATGTGAATGGGAAGCTTGTGACGGAGCCGCTGGTG
CTGAAGTCAGGGAATAGGATTGTGATGGGCAAGAACCACGTTTTCCGCTTCAACCACCCG
GAGCAGGCAAGGCTGGAACGGGAACGAGGGGTCCCCCCACCCCCAGGACCGCCCTCTGAG
CCAGTCGACTGGAACTTTGCCCAGAAGGAACTGCTGGAGCAGCAAGGCATCGACATAAAG
CTGGAAATGGAGAAGAGGCTGCAGGATCTGGAGAATCAGTACCGGAAAGAAAAGGAAGAA
GCCGATCTTCTGCTGGAGCAGCAGCGACTGTATGCAGACTCGGACAGCGGGGATGACTCT
GACAAGCGCTCTTGTGAAGAGAGCTGGAGGCTCATCTCCTCCTTGCGGGAGCAGCTGCCG
CCCACCACGGTCCAGACCATTGTCAAACGCTGTGGTCTGCCCAGCAGTGGCAAGCGCAGG
GCCCCTCGCAGGGTTTATCAGATCCCCCAGCGACGCAGGCTGCAGGGCAAAGACCCCCGC
TGGGCCACCATGGCTGACCTGAAGATGCAGGCGGTGAAGGAGATCTGCTACGAGGTGGCC
CTGGCTGACTTCCGCCACGGGCGGGCTGAGATTGAGGCCCTGGCCGCCCTCAAGATGCGG
GAGCTGTGTCGCACCTATGGCAAGCCAGACGGCCCCGGAGACGCCTGGAGGGCTGTGGCC
CGGGATGTCTGGGACACTGTAGGCGAGGAGGAAGGAGGTGGAGCTGGCAGTGGTGGTGGC
AGTGAGGAGGGAGCCCGAGGGGCGGAGGTGGAGGACCTCCGGGCCCACATCGACAAGCTG
ACGGGGATTCTGCAGGAGGTGAAGCTGCAGAACAGCAGCAAGGACCGGGAGCTGCAGGCC
CTGCGGGACCGCATGCTCCGCATGGAGAGGGTCATCCCCCTGGCCCAGGATCATGAGGAT
GAGAATGAAGAAGGTGGTGAGGTCCCCTGGGCCCCGCCTGAAGGATCAGAGGCAGCAGAG
GAGGCAGCCCCCAGTGACCGCATGCCGTCAGCCCGGCCCCCCTCGCCACCACTGTCAAGC
TGGGAGCGGGTGTCACGGCTCATGGAGGAGGACCCTGCCTTCCGTCGTGGTCGTCTTCGC
TGGCTCAAGCAGGAGCAGCTACGGCTGCAGGGACTGCAGGGCTCTGGGGGCCGGGGCGGG
GGGCTGCGCAGGCCCCCAGCCCGCTTTGTGCCCCCTCACGACTGCAAGCTACGCTTCCCC
TTCAAGAGCAACCCCCAGCACCGGGAGTCTTGGCCAGGGATGGGGAGCGGGGAGGCTCCA
ACTCCGCTCCAACCCCCTGAGGAGGTCACTCCCCATCCAGCCACCCCTGCCCGCCGGCCT
CCGAGTCCCCGAAGGTCCCACCATCCCCGCAGGAACTCCCTGGATGGAGGGGGCCGATCC
CGGGGAGCGGGTTCTGCACAGCCTGAACCCCAGCACTTCCAGCCCAAAAAGCACAACTCT
TATCCCCAGCCACCCCAACCCTACCCAGCCCAGCGGCCCCCAGGGCCCCGCTACCCCCCA
TACACTACTCCCCCACGAATGAGACGGCAGCGTTCTGCCCCTGACCTCAAGGAGAGTGGG
GCAGCTGTGTGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:6317
Chromosome Location17
LocusNone
References
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  2. Dor T, Cinnamon Y, Raymond L, Shaag A, Bouslam N, Bouhouche A, Gaussen M, Meyer V, Durr A, Brice A, Benomar A, Stevanin G, Schuelke M, Edvardson S: KIF1C mutations in two families with hereditary spastic paraparesis and cerebellar dysfunction. J Med Genet. 2014 Feb;51(2):137-42. doi: 10.1136/jmedgenet-2013-102012. Epub 2013 Dec 6.[24319291 ]
  3. Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R: Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum. J Biol Chem. 1998 Aug 7;273(32):20267-75.[9685376 ]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  5. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48.[17081983 ]
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