Kinesin heavy chain isoform 5C

NameKinesin heavy chain isoform 5C
SynonymsKIAA0531 Kinesin heavy chain neuron-specific 2 NKHC2
Gene NameKIF5C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009165|Kinesin heavy chain isoform 5C
MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQE
QVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEV
MDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTI
VICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVI
QHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEE
ISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAA
KDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELS
NHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKS
LVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEES
QDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSR
LRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQA
REDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENN
LEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQE
VDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK
Number of residues957
Molecular Weight109494.01
Theoretical pINone
GO Classification
Functions
    ATP-dependent microtubule motor activity, plus-end-directed
ATP binding
microtubule motor activity
Processes
    protein localization
mRNA transport
microtubule-based movement
axon guidance
cytoskeleton-dependent intracellular transport
organelle organization
Components
    kinesin complex
cytoplasm
microtubule
General FunctionMicrotubule motor activity
Specific FunctionMediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDO60282
UniProtKB Entry NameKIF5C_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013647|Kinesin heavy chain isoform 5C (KIF5C)
ATGGCGGATCCAGCCGAATGCAGCATCAAAGTGATGTGCCGGTTCCGGCCCCTCAACGAA
GCGGAGATCCTCCGCGGGGACAAATTCATCCCCAAATTTAAAGGCGATGAGACCGTGGTG
ATCGGGCAAGGGAAGCCATATGTCTTCGACAGAGTGCTACCTCCCAACACGACCCAAGAG
CAGGTTTACAATGCATGTGCGAAGCAAATTGTCAAAGATGTCCTTGAAGGTTATAACGGG
ACGATTTTTGCGTATGGGCAGACTTCATCAGGAAAAACCCACACCATGGAGGGGAAGCTG
CATGACCCCCAGCTCATGGGGATCATCCCACGAATTGCCCATGATATCTTTGACCATATC
TACTCCATGGATGAGAACCTGGAGTTTCACATAAAGGTTTCCTATTTTGAGATCTACTTG
GACAAAATAAGGGACTTACTTGATGTATCCAAGACCAACTTGGCTGTTCATGAAGATAAA
AACAGAGTCCCGTATGTAAAGGGGTGCACTGAGCGGTTTGTGTCGAGCCCTGAGGAAGTC
ATGGATGTAATAGATGAAGGCAAAGCAAACCGACACGTGGCTGTGACAAACATGAATGAA
CACAGCTCTAGAAGTCACAGTATCTTCCTGATAAATATTAAACAAGAGAATGTAGAGACT
GAAAAAAAACTCAGTGGGAAACTTTATTTGGTTGATTTGGCTGGGAGCGAAAAGGTCAGC
AAAACTGGTGCCGAGGGAGCTGTTCTTGACGAAGCTAAAAATATCAATAAGTCTTTGTCT
GCTCTTGGAAATGTGATCTCTGCTTTGGCAGAAGGGACAAAAACACATGTGCCATACCGG
GACAGCAAGATGACTCGGATTCTTCAGGACTCTTTGGGTGGGAACTGCAGAACCACCATC
GTCATTTGCTGTTCTCCTTCTGTCTTCAATGAGGCTGAGACCAAGTCCACACTGATGTTC
GGACAGAGAGCTAAGACCATCAAGAATACAGTCTCTGTGAACCTAGAACTGACAGCAGAA
GAATGGAAGAAGAAATATGAAAAAGAGAAAGAGAAAAACAAGACTTTGAAGAATGTTATC
CAGCATCTGGAGATGGAGCTAAACAGGTGGAGGAATGGAGAAGCTGTGCCTGAGGATGAA
CAGATCAGTGCCAAGGACCAGAAGAACCTGGAGCCTTGTGATAACACCCCCATCATAGAC
AATATTGCTCCTGTTGTTGCTGGCATCTCTACAGAGGAGAAAGAGAAGTACGATGAGGAG
ATCTCCAGTCTCTACAGACAACTGGATGACAAGGATGATGAAATTAACCAGCAGAGCCAG
CTGGCTGAAAAGCTGAAGCAACAGATGTTGGATCAGGATGAGCTTTTAGCTTCCACAAGA
AGAGACTATGAGAAGATACAGGAGGAGCTGACACGTCTCCAGATTGAAAATGAGGCAGCC
AAGGATGAGGTGAAAGAAGTTCTCCAGGCCCTGGAGGAGCTGGCTGTCAATTATGACCAG
AAATCACAGGAAGTGGAGGATAAGACCCGGGCCAATGAGCAGCTGACAGACGAGCTGGCC
CAGAAAACGACTACATTGACAACCACACAGAGAGAGCTGAGCCAGCTACAAGAGCTTAGC
AACCACCAGAAGAAAAGGGCAACTGAGATCCTGAATTTGCTGTTGAAAGATCTGGGGGAG
ATAGGTGGAATTATTGGCACCAATGATGTGAAAACTTTGGCAGATGTGAATGGAGTCATT
GAGGAGGAGTTTACCATGGCCCGCCTGTACATCAGCAAGATGAAGTCAGAGGTCAAGTCC
CTGGTGAACCGCAGCAAACAGCTCGAGAGCGCCCAGATGGACTCCAACAGGAAGATGAAT
GCCAGCGAGCGGGAGCTGGCAGCCTGCCAGCTGCTCATCTCCCAGCACGAAGCCAAGATC
AAGTCTCTGACAGACTACATGCAGAACATGGAACAGAAGAGGAGGCAGCTAGAAGAGTCC
CAGGACTCGCTCAGCGAAGAGCTGGCAAAGCTCCGAGCCCAGGAAAAAATGCACGAAGTC
AGCTTCCAGGATAAGGAGAAGGAACATCTGACGCGGTTGCAGGATGCTGAAGAAATGAAG
AAGGCGCTGGAGCAGCAGATGGAGAGCCACCGGGAAGCTCACCAGAAGCAGCTGTCCAGA
CTCCGAGACGAAATTGAGGAGAAGCAGAAAATCATTGATGAGATTCGGGATTTGAATCAG
AAACTGCAACTGGAACAGGAGAAGCTTAGTTCTGATTATAACAAGCTGAAAATAGAGGAC
CAAGAGAGAGAAATGAAGCTGGAAAAGCTCTTATTGCTCAACGATAAAAGGGAACAAGCC
AGAGAAGACCTCAAAGGGCTGGAGGAGACAGTGTCTAGAGAATTGCAGACACTGCACAAC
CTTCGGAAACTCTTTGTCCAGGATCTGACCACCCGAGTTAAAAAAAGTGTGGAGTTGGAC
AACGATGATGGAGGGGGCAGTGCTGCCCAGAAGCAGAAAATTTCCTTCTTGGAGAATAAC
CTGGAGCAGCTCACCAAAGTTCACAAGCAGCTGGTCCGGGACAACGCAGACCTGCGCTGT
GAACTGCCCAAGCTGGAGAAGCGGCTGCGTGCCACGGCGGAGCGCGTCAAGGCTCTGGAG
AGCGCGCTGAAGGAGGCCAAGGAGAACGCCATGCGGGACCGTAAGCGCTACCAGCAGGAG
GTGGATCGTATCAAGGAGGCCGTGCGGGCCAAGAACATGGCCAGAAGGGCCCATTCAGCC
CAGATCGCCAAGCCCATCCGCCCCGGACACTACCCGGCCTCATCTCCAACGGCCGTCCAT
GCCATTCGAGGGGGAGGAGGCAGCTCTTCAAATTCCACTCACTACCAGAAATAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:6325
Chromosome Location2
LocusNone
References
  1. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998 Feb 28;5(1):31-9.[9628581 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  3. Engelender S, Sharp AH, Colomer V, Tokito MK, Lanahan A, Worley P, Holzbaur EL, Ross CA: Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum Mol Genet. 1997 Dec;6(13):2205-12.[9361024 ]
  4. Brickley K, Smith MJ, Beck M, Stephenson FA: GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J Biol Chem. 2005 Apr 15;280(15):14723-32. Epub 2005 Jan 11.[15644324 ]
  5. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17.[21269460 ]
  6. de Ligt J, Willemsen MH, van Bon BW, Kleefstra T, Yntema HG, Kroes T, Vulto-van Silfhout AT, Koolen DA, de Vries P, Gilissen C, del Rosario M, Hoischen A, Scheffer H, de Vries BB, Brunner HG, Veltman JA, Vissers LE: Diagnostic exome sequencing in persons with severe intellectual disability. N Engl J Med. 2012 Nov 15;367(20):1921-9. doi: 10.1056/NEJMoa1206524. Epub 2012 Oct 3.[23033978 ]
  7. Poirier K, Lebrun N, Broix L, Tian G, Saillour Y, Boscheron C, Parrini E, Valence S, Pierre BS, Oger M, Lacombe D, Genevieve D, Fontana E, Darra F, Cances C, Barth M, Bonneau D, Bernadina BD, N'guyen S, Gitiaux C, Parent P, des Portes V, Pedespan JM, Legrez V, Castelnau-Ptakine L, Nitschke P, Hieu T, Masson C, Zelenika D, Andrieux A, Francis F, Guerrini R, Cowan NJ, Bahi-Buisson N, Chelly J: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat Genet. 2013 Jun;45(6):639-47. doi: 10.1038/ng.2613. Epub 2013 Apr 21.[23603762 ]
  8. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31.[15815621 ]

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