Ribonuclease H1
| Name | Ribonuclease H1 |
|---|---|
| Synonyms | 3.1.26.4 Ribonuclease H type II RNase H1 RNH1 |
| Gene Name | RNASEH1 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0013656|Ribonuclease H1 MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKK FATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKP SVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQ TNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVIN KEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED |
| Number of residues | 286 |
| Molecular Weight | 32064.035 |
| Theoretical pI | None |
| GO Classification |
Functions
RNA binding magnesium ion binding ribonuclease activity RNA-DNA hybrid ribonuclease activity nucleic acid binding Processes
RNA catabolic process RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic DNA replication, removal of RNA primer Components
mitochondrion |
| General Function | Rna-dna hybrid ribonuclease activity |
| Specific Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). |
| Transmembrane Regions | |
| GenBank Protein ID | |
| UniProtKB ID | O60930 |
| UniProtKB Entry Name | RNH1_HUMAN |
| Cellular Location | Cytoplasm |
| Gene sequence | >lcl|BSEQ0013657|Ribonuclease H1 (RNASEH1) ATGTTCTATGCCGTGAGGAGGGGCCGCAAGACCGGGGTCTTTCTGACCTGGAATGAGTGC AGAGCACAGGTGGACCGGTTTCCTGCTGCCAGATTTAAGAAGTTTGCCACAGAGGATGAG GCCTGGGCCTTTGTCAGGAAATCTGCAAGCCCGGAAGTTTCAGAAGGGCATGAAAATCAA CATGGACAAGAATCGGAGGCGAAAGCCAGCAAGCGACTCCGTGAGCCACTGGATGGAGAT GGACATGAAAGCGCAGAGCCGTATGCAAAGCACATGAAGCCGAGCGTGGAGCCGGCGCCT CCAGTTAGCAGAGACACGTTTTCCTACATGGGAGACTTCGTCGTCGTCTACACTGATGGC TGCTGCTCCAGTAATGGGCGTAGAAGGCCGCGAGCAGGAATCGGCGTTTACTGGGGGCCA GGCCATCCTTTAAATGTAGGCATTAGACTTCCTGGGCGGCAGACAAACCAAAGAGCGGAA ATTCATGCAGCCTGCAAAGCCATTGAACAAGCAAAGACTCAAAACATCAATAAACTGGTT CTGTATACAGACAGTATGTTTACGATAAATGGTATAACTAACTGGGTTCAAGGTTGGAAG AAAAATGGGTGGAAGACAAGTGCAGGGAAAGAGGTGATCAACAAAGAGGACTTTGTGGCA CTGGAGAGGCTTACCCAGGGGATGGACATTCAGTGGATGCATGTTCCTGGTCATTCGGGA TTTATAGGCAATGAAGAAGCTGACAGATTAGCCAGAGAAGGAGCTAAACAATCGGAAGAC TGA |
| GenBank Gene ID | |
| GeneCard ID | None |
| GenAtlas ID | |
| HGNC ID | HGNC:18466 |
| Chromosome Location | 2 |
| Locus | None |
| References |
|
Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
Patulin |
154.121 |
||
Luteoskyrin |
574.494 |