Ribonuclease H1
Name | Ribonuclease H1 |
---|---|
Synonyms | 3.1.26.4 Ribonuclease H type II RNase H1 RNH1 |
Gene Name | RNASEH1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0013656|Ribonuclease H1 MSWLLFLAHRVALAALPCRRGSRGFGMFYAVRRGRKTGVFLTWNECRAQVDRFPAARFKK FATEDEAWAFVRKSASPEVSEGHENQHGQESEAKASKRLREPLDGDGHESAEPYAKHMKP SVEPAPPVSRDTFSYMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQ TNQRAEIHAACKAIEQAKTQNINKLVLYTDSMFTINGITNWVQGWKKNGWKTSAGKEVIN KEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQSED |
Number of residues | 286 |
Molecular Weight | 32064.035 |
Theoretical pI | None |
GO Classification |
Functions
RNA binding magnesium ion binding ribonuclease activity RNA-DNA hybrid ribonuclease activity nucleic acid binding Processes
RNA catabolic process RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic DNA replication, removal of RNA primer Components
mitochondrion |
General Function | Rna-dna hybrid ribonuclease activity |
Specific Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). |
Transmembrane Regions | |
GenBank Protein ID | |
UniProtKB ID | O60930 |
UniProtKB Entry Name | RNH1_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0013657|Ribonuclease H1 (RNASEH1) ATGTTCTATGCCGTGAGGAGGGGCCGCAAGACCGGGGTCTTTCTGACCTGGAATGAGTGC AGAGCACAGGTGGACCGGTTTCCTGCTGCCAGATTTAAGAAGTTTGCCACAGAGGATGAG GCCTGGGCCTTTGTCAGGAAATCTGCAAGCCCGGAAGTTTCAGAAGGGCATGAAAATCAA CATGGACAAGAATCGGAGGCGAAAGCCAGCAAGCGACTCCGTGAGCCACTGGATGGAGAT GGACATGAAAGCGCAGAGCCGTATGCAAAGCACATGAAGCCGAGCGTGGAGCCGGCGCCT CCAGTTAGCAGAGACACGTTTTCCTACATGGGAGACTTCGTCGTCGTCTACACTGATGGC TGCTGCTCCAGTAATGGGCGTAGAAGGCCGCGAGCAGGAATCGGCGTTTACTGGGGGCCA GGCCATCCTTTAAATGTAGGCATTAGACTTCCTGGGCGGCAGACAAACCAAAGAGCGGAA ATTCATGCAGCCTGCAAAGCCATTGAACAAGCAAAGACTCAAAACATCAATAAACTGGTT CTGTATACAGACAGTATGTTTACGATAAATGGTATAACTAACTGGGTTCAAGGTTGGAAG AAAAATGGGTGGAAGACAAGTGCAGGGAAAGAGGTGATCAACAAAGAGGACTTTGTGGCA CTGGAGAGGCTTACCCAGGGGATGGACATTCAGTGGATGCATGTTCCTGGTCATTCGGGA TTTATAGGCAATGAAGAAGCTGACAGATTAGCCAGAGAAGGAGCTAAACAATCGGAAGAC TGA |
GenBank Gene ID | |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:18466 |
Chromosome Location | 2 |
Locus | None |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Patulin |
154.121 |
||
Luteoskyrin |
574.494 |