Programmed cell death protein 6

NameProgrammed cell death protein 6
SynonymsALG2 Apoptosis-linked gene 2 protein Probable calcium-binding protein ALG-2
Gene NamePDCD6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009841|Programmed cell death protein 6
MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPF
NPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALS
GFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSY
EQYLSMVFSIV
Number of residues191
Molecular Weight21868.32
Theoretical pINone
GO Classification
Functions
    calcium-dependent protein binding
identical protein binding
calcium ion binding
calcium-dependent cysteine-type endopeptidase activity
binding, bridging
protein dimerization activity
protein anchor
Processes
    activation of cysteine-type endopeptidase activity involved in apoptotic process
vascular endothelial growth factor receptor-2 signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of TOR signaling
response to calcium ion
cellular response to heat
proteolysis
negative regulation of protein kinase B signaling
angiogenesis
intracellular protein transport
positive regulation of endothelial cell migration
positive regulation of angiogenesis
apoptotic signaling pathway
positive regulation of endothelial cell proliferation
negative regulation of vascular endothelial growth factor receptor signaling pathway
Components
    cytoplasmic vesicle
extracellular exosome
nuclear membrane
cytoplasm
endosome
nucleus
endoplasmic reticulum exit site
endoplasmic reticulum
endoplasmic reticulum membrane
General FunctionProtein dimerization activity
Specific FunctionCalcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDO75340
UniProtKB Entry NamePDCD6_HUMAN
Cellular LocationNucleus membrane
Gene sequence
>lcl|BSEQ0017845|Programmed cell death protein 6 (PDCD6)
ATGGCCGCCTACTCTTACCGCCCCGGCCCTGGGGCCGGCCCTGGGCCTGCTGCAGGCGCG
GCGCTGCCGGACCAGAGCTTCCTGTGGAACGTTTTCCAGAGGGTCGATAAAGACAGGAGT
GGAGTGATATCAGACACCGAGCTTCAGCAAGCTCTCTCCAACGGCACGTGGACTCCCTTT
AATCCAGTGACTGTCAGGTCGATCATATCCATGTTTGACCGTGAGAACAAGGCCGGCGTG
AACTTCAGCGAGTTCACGGGTGTGTGGAAGTACATCACGGACTGGCAGAACGTCTTCCGC
ACGTACGACCGGGACAACTCCGGGATGATCGATAAGAACGAGCTGAAGCAGGCCCTCTCA
GGCTACCGGCTCTCTGACCAGTTCCACGACATCCTCATTCGAAAGTTTGACAGGCAGGGA
CGGGGGCAGATTGCCTTCGACGACTTCATCCAGGGCTGCATCGTCCTGCAGAGGTTGACG
GATATATTCAGACGTTACGACACGGATCAGGACGGCTGGATTCAGGTGTCGTACGAACAG
TACCTGTCCATGGTCTTCAGTATCGTATGA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:8765
Chromosome Location5
LocusNone
References
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