SEC14-like protein 2
| Name | SEC14-like protein 2 |
|---|---|
| Synonyms | Alpha-tocopherol-associated protein C22orf6 hTAP KIAA1186 KIAA1658 SPF Squalene transfer protein Supernatant protein factor TAP |
| Gene Name | SEC14L2 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0000511|SEC14-like protein 2 MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHV EFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDL LRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEE NYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVE YGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPG CVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGI YVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK |
| Number of residues | 403 |
| Molecular Weight | 46144.9 |
| Theoretical pI | 7.94 |
| GO Classification |
Functions
transporter activity vitamin E binding transferase activity, transferring alkyl or aryl (other than methyl) groups phospholipid binding enzyme activator activity Processes
positive regulation of transcription, DNA-templated regulation of cholesterol biosynthetic process transcription, DNA-templated positive regulation of cholesterol biosynthetic process Components
extracellular exosome cytoplasm nucleus integral component of membrane cytosol |
| General Function | Vitamin e binding |
| Specific Function | Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. |
| Transmembrane Regions | |
| GenBank Protein ID | 5596693 |
| UniProtKB ID | O76054 |
| UniProtKB Entry Name | S14L2_HUMAN |
| Cellular Location | Cytoplasm |
| Gene sequence | >lcl|BSEQ0016047|SEC14-like protein 2 (SEC14L2) ATGAGCGGCAGAGTCGGCGATCTGAGCCCCAGGCAGAAGGAGGCATTGGCCAAGTTTCGG GAGAATGTCCAGGATGTGCTGCCGGCCCTGCCGAATCCAGATGACTATTTTCTCCTGCGT TGGCTCCGAGCCAGAAGCTTCGACCTGCAGAAGTCGGAGGCCATGCTCCGGAAGTTGGGG AGGAAGGTGGAGACCATCACCATAATTTATGACTGCGAGGGGCTTGGCCTCAAGCATCTC TGGAAGCCTGCTGTGGAGGCCTATGGAGAGTTTCTCTGCATGTTTGAGGAAAATTATCCC GAAACACTGAAGCGTCTTTTTGTTGTTAAAGCCCCCAAACTGTTTCCTGTGGCCTATAAC CTCATCAAACCCTTCCTGAGTGAGGACACTCGTAAGAAGATCATGGTCCTGGGAGCAAAT TGGAAGGAGGTTTTACTGAAACATATCAGCCCTGACCAGGTGCCTGTGGAGTATGGGGGC ACCATGACTGACCCTGATGGAAACCCCAAGTGCAAATCCAAGATCAACTACGGGGGTGAC ATCCCCAGGAAGTATTATGTGCGAGACCAGGTGAAACAGCAGTATGAACACAGCGTGCAG ATTTCCCGTGGCTCCTCCCACCAAGTGGAGTATGAGATCCTCTTCCCTGGCTGTGTCCTC AGGTGGCAGTTTATGTCAGATGGAGCGGATGTTGGTTTTGGGATTTTCCTGAAGACCAAG ATGGGAGAGAGGCAGCGGGCAGGGGAGATGACAGAGGTGCTGCCCAACCAGAGGTACAAC TCCCACCTGGTCCCTGAAGATGGGACCCTCACCTGCAGTGATCCTGGCATCTATGTCCTG CGGTTTGACAACACCTACAGCTTCATTCATGCCAAGAAGGTCAATTTCACTGTGGAGGTC CTGCTTCCAGACAAAGCCTCAGAAGAGAAGATGAAACAGCTGGGGGCAGGCACCCCGAAA TAA |
| GenBank Gene ID | AL096881 |
| GeneCard ID | None |
| GenAtlas ID | SEC14L2 |
| HGNC ID | HGNC:10699 |
| Chromosome Location | 22 |
| Locus | 22q12.2 |
| References |
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Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
Alpha-Tocopherol |
430.717 |