Retinal dehydrogenase 2
Name | Retinal dehydrogenase 2 |
---|---|
Synonyms | 1.2.1.36 Aldehyde dehydrogenase family 1 member A2 RALDH 2 RALDH(II) RALDH2 Retinaldehyde-specific dehydrogenase type 2 |
Gene Name | ALDH1A2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0001024|Retinal dehydrogenase 2 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS |
Number of residues | 518 |
Molecular Weight | 56723.495 |
Theoretical pI | 5.84 |
GO Classification |
Functions
retinal dehydrogenase activity aldehyde dehydrogenase (NAD) activity 3-chloroallyl aldehyde dehydrogenase activity retinal binding Processes
negative regulation of cell proliferation hindbrain development response to cytokine positive regulation of cell proliferation determination of bilateral symmetry vitamin A metabolic process face development kidney development embryonic camera-type eye development midgut development retinal metabolic process ureter maturation retinol metabolic process heart morphogenesis neural tube development pituitary gland development morphogenesis of embryonic epithelium cardiac muscle tissue development positive regulation of apoptotic process embryonic forelimb morphogenesis embryonic digestive tract development pancreas development blood vessel development proximal/distal pattern formation liver development retinoic acid receptor signaling pathway cellular response to retinoic acid 9-cis-retinoic acid biosynthetic process positive regulation of gene expression regulation of endothelial cell proliferation response to estradiol neuron differentiation neural crest cell development lung development anterior/posterior pattern specification response to vitamin A retinoic acid metabolic process Components
cytoplasm cytosol perinuclear region of cytoplasm |
General Function | Retinal dehydrogenase activity |
Specific Function | Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity). |
Transmembrane Regions | |
GenBank Protein ID | 3970842 |
UniProtKB ID | O94788 |
UniProtKB Entry Name | AL1A2_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0016114|Retinal dehydrogenase 2 (ALDH1A2) ATGAAGAATCAGTGTGAGACTGTTTGGTTAAAATCCCCAATAAAACTGAAACTGATCTTT ATAAACAACGAGTGGCAGAACTCAGAGAGTGGGAGAGTGTTCCCTGTCTATAATCCAGCC ACAGGAGAACAGGTGTGTGAAGTTCAAGAAGCAGACAAGGCAGATATAGACAAAGCAGTG CAGGCAGCCCGCCTGGCTTTCTCTCTTGGTTCAGTGTGGAGAAGGATGGATGCTTCAGAA AGGGGACGTCTGTTGGATAAGCTTGCAGACTTGGTGGAACGGGACAGGGCAGTTCTTGCA ACCATGGAATCCCTAAATGGTGGCAAACCATTCCTGCAAGCTTTTTATGTGGATTTGCAG GGCGTCATCAAAACCTTTCGATATTACGCAGGCTGGGCTGATAAAATTCATGGGATGACC ATTCCTGTAGATGGAGACTATTTTACCTTTACAAGACATGAACCCATTGGAGTGTGTGGA CAGATCATCCCATGGAACTTCCCCCTGCTGATGTTTGCCTGGAAAATAGCTCCAGCTTTG TGCTGTGGCAATACAGTAGTTATTAAGCCAGCAGAGCAAACACCACTCAGTGCACTCTAC ATGGGAGCCCTCATCAAGGAGGCTGGCTTTCCTCCCGGGGTCATCAATATTTTGCCAGGA TATGGGCCAACGGCTGGGGCAGCAATAGCTTCTCACATTGGCATAGACAAGATTGCATTC ACAGGGTCTACTGAGGTTGGAAAGCTTATCCAAGAAGCAGCTGGAAGAAGTAATTTGAAG AGAGTAACTCTGGAACTTGGAGGCAAAAGTCCTAATATTATTTTTGCTGATGCTGACTTG GACTATGCTGTGGAGCAGGCCCACCAGGGTGTGTTCTTCAATCAAGGTCAGTGCTGCACT GCAGGCTCTCGCATCTTCGTGGAGGAGTCCATCTATGAGGAGTTTGTGAGAAGAAGCGTG GAGCGGGCCAAGAGGCGCGTAGTGGGGAGTCCCTTTGACCCCACCACTGAGCAGGGTCCC CAGATTGATAAGAAACAGTACAACAAGATCTTGGAACTCATCCAGAGTGGTGTGGCTGAG GGCGCCAAGCTGGAATGTGGAGGCAAAGGACTGGGCCGAAAGGGGTTTTTCATTGAGCCC ACAGTGTTTTCCAACGTCACTGATGATATGCGGATTGCCAAGGAGGAGATCTTTGGCCCT GTTCAGGAAATTTTGAGATTTAAGACGATGGATGAAGTTATCGAAAGAGCCAATAACTCA GACTTTGGACTCGTAGCAGCTGTCTTTACTAATGACATCAACAAGGCCCTCACAGTGTCT TCTGCAATGCAAGCTGGGACTGTTTGGATCAATTGTTACAATGCCTTAAATGCCCAGAGC CCCTTTGGGGGATTCAAGATGTCTGGAAATGGGAGAGAAATGGGAGAATTTGGCTTGCGG GAGTACTCAGAAGTTAAGACGGTGACAGTAAAGATCCCCCAGAAGAACTCCTAA |
GenBank Gene ID | AB015226 |
GeneCard ID | None |
GenAtlas ID | ALDH1A2 |
HGNC ID | HGNC:15472 |
Chromosome Location | 15 |
Locus | 15q22.1 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Vitamin A |
286.459 |
||
Acrolein |
56.064 |