Ornithine decarboxylase antizyme 2

NameOrnithine decarboxylase antizyme 2
SynonymsAZ2
Gene NameOAZ2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004383|Ornithine decarboxylase antizyme 2
MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKD
EKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLL
ALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYP
LDQNLSDED
Number of residues189
Molecular Weight21010.94
Theoretical pI5.03
GO Classification
Functions
    ornithine decarboxylase inhibitor activity
Processes
    negative regulation of polyamine transmembrane transport
positive regulation of protein catabolic process
regulation of cellular amino acid metabolic process
cellular nitrogen compound metabolic process
small molecule metabolic process
positive regulation of intracellular protein transport
polyamine metabolic process
polyamine biosynthetic process
Components
    nucleus
cytosol
General FunctionOrnithine decarboxylase inhibitor activity
Specific FunctionOrnithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Transmembrane Regions
GenBank Protein ID3766170
UniProtKB IDO95190
UniProtKB Entry NameOAZ2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0004382|570 bp
ATGATAAACACCCAGGACAGTAGTATTTTGCCTTTGAGTAACTGTCCCCAGCTCCAGTGC
TGCAGGCACATTGTTCCAGGGCCTCTGTGGTGCTCCGATGCCCCTCACCCACTGTCGAAG
ATCCCCGGTGGGCGAGGGGGCGGCAGGGATCCTTCTCTCTCAGCTCTAATATATAAGGAC
GAGAAGCTCACTGTGACCCAGGACCTCCCTGTGAATGATGGAAAACCTCACATCGTCCAC
TTCCAGTATGAGGTCACCGAGGTGAAGGTCTCTTCTTGGGATGCAGTCCTGTCCAGCCAG
AGCCTGTTTGTAGAAATCCCAGATGGATTATTAGCTGATGGGAGCAAAGAAGGATTGTTA
GCACTGCTAGAGTTTGCTGAAGAGAAGATGAAAGTGAACTATGTCTTCATCTGCTTCAGG
AAGGGCCGAGAAGACAGAGCTCCACTCCTGAAGACCTTCAGCTTCTTGGGCTTTGAGATT
GTACGTCCAGGCCATCCCTGTGTCCCCTCTCGGCCAGATGTGATGTTCATGGTTTATCCC
CTGGACCAGAACTTGTCCGATGAGGACTAA
GenBank Gene IDAF057297
GeneCard IDNone
GenAtlas IDOAZ2
HGNC IDHGNC:8096
Chromosome LocationNone
Locus15q22.31
References
  1. Ivanov IP, Gesteland RF, Atkins JF: A second mammalian antizyme: conservation of programmed ribosomal frameshifting. Genomics. 1998 Sep 1;52(2):119-29.[9782076 ]
  2. Zhou J, Atkins JF, Gesteland RF: Structure of human ornithine decarboxylase antizyme 2 gene. Gene. 1999 May 31;232(2):165-71.[10352227 ]
  3. Kanerva K, Makitie LT, Pelander A, Heiskala M, Andersson LC: Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. Biochem J. 2008 Jan 1;409(1):187-92.[17900240 ]

Related FRC

FRCD ID Name Exact Mass Structure




F05342



Ornithine


132.163