Lecithin retinol acyltransferase
Name | Lecithin retinol acyltransferase |
---|---|
Synonyms | 2.3.1.135 Phosphatidylcholine--retinol O-acyltransferase |
Gene Name | LRAT |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0010633|Lecithin retinol acyltransferase MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTH YGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGA NILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDK FCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG |
Number of residues | 230 |
Molecular Weight | 25702.635 |
Theoretical pI | 7.54 |
GO Classification |
Functions
transferase activity, transferring acyl groups retinoic acid binding phosphatidylcholine-retinol O-acyltransferase activity retinol binding Processes
vitamin A metabolic process retinol metabolic process retinoic acid metabolic process visual perception positive regulation of lipid transport phototransduction, visible light retinoid metabolic process Components
rough endoplasmic reticulum endoplasmic reticulum membrane multivesicular body integral component of membrane perinuclear region of cytoplasm |
General Function | Transferase activity, transferring acyl groups |
Specific Function | Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. |
Transmembrane Regions | 195-215 |
GenBank Protein ID | 4240391 |
UniProtKB ID | O95237 |
UniProtKB Entry Name | LRAT_HUMAN |
Cellular Location | Endoplasmic reticulum membrane |
Gene sequence | >lcl|BSEQ0010634|Lecithin retinol acyltransferase (LRAT) ATGAAGAACCCCATGCTGGAGGTGGTGTCTTTACTACTGGAGAAGCTGCTCCTCATCTCC AACTTCACGCTCTTTAGTTCGGGCGCCGCGGGCGAAGACAAAGGGAGGAACAGTTTTTAT GAAACCAGCTCTTTCCACCGAGGCGACGTGCTGGAGGTGCCCCGGACCCACCTGACCCAC TATGGCATCTACCTAGGAGACAACCGTGTTGCCCACATGATGCCCGACATCCTGTTGGCC CTGACAGACGACATGGGGCGCACGCAGAAGGTGGTCTCCAACAAGCGTCTCATCCTGGGC GTTATTGTCAAAGTGGCCAGCATCCGCGTGGACACAGTGGAGGACTTCGCCTACGGAGCT AACATCCTGGTCAATCACCTGGACGAGTCCCTCCAGAAAAAGGCACTGCTCAACGAGGAG GTGGCGCGGAGGGCTGAAAAGCTGCTGGGCTTTACCCCCTACAGCCTGCTGTGGAACAAC TGCGAGCACTTCGTGACCTACTGCAGATATGGCACCCCGATCAGTCCCCAGTCCGACAAG TTTTGTGAGACTGTGAAGATAATTATTCGTGATCAGAGAAGTGTTCTTGCTTCAGCAGTC TTGGGATTGGCGTCTATAGTCTGTACGGGCTTGGTATCATACACTACCCTTCCTGCAATT TTTATTCCATTCTTCCTATGGATGGCTGGCTAA |
GenBank Gene ID | AF071510 |
GeneCard ID | None |
GenAtlas ID | LRAT |
HGNC ID | HGNC:6685 |
Chromosome Location | 4 |
Locus | 4q32.1 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Vitamin A |
286.459 |