Apolipoprotein A-I


NameApolipoprotein A-I
SynonymsApo-AI Apolipoprotein A1
Gene NameAPOA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017103|Apolipoprotein A-I
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
GLLPVLESFKVSFLSALEEYTKKLNTQ
Number of residues267
Molecular Weight30777.58
Theoretical pI5.5
GO Classification
Functions
    phosphatidylcholine binding
    chemorepellent activity
    high-density lipoprotein particle receptor binding
    phosphatidylcholine-sterol O-acyltransferase activator activity
    cholesterol binding
    lipase inhibitor activity
    cholesterol transporter activity
    enzyme binding
    phospholipid transporter activity
    beta-amyloid binding
    phospholipid binding
    high-density lipoprotein particle binding
    apolipoprotein A-I receptor binding
    apolipoprotein receptor binding
    identical protein binding
Processes
    lipoprotein metabolic process
    positive regulation of hydrolase activity
    receptor-mediated endocytosis
    response to nutrient
    lipid storage
    negative regulation of inflammatory response
    protein stabilization
    vitamin transport
    phospholipid efflux
    positive regulation of fatty acid biosynthetic process
    cellular protein metabolic process
    retinoid metabolic process
    regulation of protein phosphorylation
    endothelial cell proliferation
    platelet activation
    phospholipid homeostasis
    cholesterol biosynthetic process
    blood coagulation
    regulation of intestinal cholesterol absorption
    lipoprotein biosynthetic process
    regulation of Cdc42 protein signal transduction
    positive regulation of stress fiber assembly
    negative regulation of cell adhesion molecule production
    reverse cholesterol transport
    platelet degranulation
    organ regeneration
    positive regulation of lipoprotein lipase activity
    triglyceride catabolic process
    small molecule metabolic process
    negative regulation of cytokine secretion involved in immune response
    cholesterol import
    G-protein coupled receptor signaling pathway
    response to drug
    positive regulation of triglyceride catabolic process
    cellular lipid metabolic process
    positive regulation of substrate adhesion-dependent cell spreading
    negative regulation of very-low-density lipoprotein particle remodeling
    high-density lipoprotein particle clearance
    negative regulation of heterotypic cell-cell adhesion
    phosphatidylcholine biosynthetic process
    very-low-density lipoprotein particle remodeling
    cholesterol efflux
    protein oxidation
    high-density lipoprotein particle remodeling
    peripheral nervous system axon regeneration
    integrin-mediated signaling pathway
    negative regulation of tumor necrosis factor-mediated signaling pathway
    cholesterol homeostasis
    peptidyl-methionine modification
    transmembrane transport
    triglyceride homeostasis
    positive regulation of cholesterol esterification
    negative regulation of interleukin-1 beta secretion
    blood vessel endothelial cell migration
    cholesterol metabolic process
    negative regulation of lipase activity
    adrenal gland development
    response to estrogen
    neuron projection regeneration
    positive regulation of Rho protein signal transduction
    cholesterol transport
    high-density lipoprotein particle assembly
    negative chemotaxis
    glucocorticoid metabolic process
    phototransduction, visible light
    negative regulation of response to cytokine stimulus
Components
    cell surface
    endocytic vesicle
    discoidal high-density lipoprotein particle
    endocytic vesicle lumen
    chylomicron
    cytoplasmic vesicle
    high-density lipoprotein particle
    extracellular vesicle
    early endosome
    extracellular region
    spherical high-density lipoprotein particle
    nucleus
    very-low-density lipoprotein particle
    cytosol
    blood microparticle
    plasma membrane
    secretory granule lumen
    extracellular exosome
    extracellular space
    endoplasmic reticulum lumen
General FunctionPhospholipid transporter activity
Specific FunctionParticipates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP02647
UniProtKB Entry NameAPOA1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0017104|Apolipoprotein A-I (APOA1)
ATGAAAGCTGCGGTGCTGACCTTGGCCGTGCTCTTCCTGACGGGGAGCCAGGCTCGGCAT
TTCTGGCAGCAAGATGAACCCCCCCAGAGCCCCTGGGATCGAGTGAAGGACCTGGCCACT
GTGTACGTGGATGTGCTCAAAGACAGCGGCAGAGACTATGTGTCCCAGTTTGAAGGCTCC
GCCTTGGGAAAACAGCTAAACCTAAAGCTCCTTGACAACTGGGACAGCGTGACCTCCACC
TTCAGCAAGCTGCGCGAACAGCTCGGCCCTGTGACCCAGGAGTTCTGGGATAACCTGGAA
AAGGAGACAGAGGGCCTGAGGCAGGAGATGAGCAAGGATCTGGAGGAGGTGAAGGCCAAG
GTGCAGCCCTACCTGGACGACTTCCAGAAGAAGTGGCAGGAGGAGATGGAGCTCTACCGC
CAGAAGGTGGAGCCGCTGCGCGCAGAGCTCCAAGAGGGCGCGCGCCAGAAGCTGCACGAG
CTGCAAGAGAAGCTGAGCCCACTGGGCGAGGAGATGCGCGACCGCGCGCGCGCCCATGTG
GACGCGCTGCGCACGCATCTGGCCCCCTACAGCGACGAGCTGCGCCAGCGCTTGGCCGCG
CGCCTTGAGGCTCTCAAGGAGAACGGCGGCGCCAGACTGGCCGAGTACCACGCCAAGGCC
ACCGAGCATCTGAGCACGCTCAGCGAGAAGGCCAAGCCCGCGCTCGAGGACCTCCGCCAA
GGCCTGCTGCCCGTGCTGGAGAGCTTCAAGGTCAGCTTCCTGAGCGCTCTCGAGGAGTAC
ACTAAGAAGCTCAACACCCAGTGA
GenBank Gene IDBC110286
GeneCard IDNone
GenAtlas IDAPOA1
HGNC IDHGNC:600
Chromosome Location11
LocusNone
References
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