C-X-C motif chemokine 10

NameC-X-C motif chemokine 10
Synonyms10 kDa interferon gamma-induced protein Gamma-IP10 INP10 IP-10 SCYB10 Small-inducible cytokine B10
Gene NameCXCL10
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016256|C-X-C motif chemokine 10
MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRV
EIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP
Number of residues98
Molecular Weight10880.915
Theoretical pI10.62
GO Classification
Functions
    cAMP-dependent protein kinase regulator activity
heparin binding
CXCR3 chemokine receptor binding
receptor binding
chemokine activity
Processes
    chemotaxis
regulation of T cell chemotaxis
cellular response to lipopolysaccharide
defense response to virus
T cell chemotaxis
positive regulation of monocyte chemotaxis
negative regulation of angiogenesis
regulation of protein kinase activity
signal transduction
regulation of cell proliferation
positive regulation of cAMP-mediated signaling
positive regulation of cAMP metabolic process
response to cold
positive regulation of leukocyte chemotaxis
positive regulation of transcription from RNA polymerase II promoter
response to vitamin D
immune response
response to auditory stimulus
blood circulation
muscle organ development
endothelial cell activation
G-protein coupled receptor signaling pathway
positive regulation of T cell migration
negative regulation of myoblast differentiation
cell surface receptor signaling pathway
response to gamma radiation
inflammatory response
negative regulation of myoblast fusion
positive regulation of cell proliferation
chemokine-mediated signaling pathway
cell-cell signaling
regulation of endothelial tube morphogenesis
positive regulation of release of sequestered calcium ion into cytosol
cellular response to heat
Components
    extracellular region
external side of plasma membrane
extracellular space
General FunctionReceptor binding
Specific FunctionChemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Transmembrane Regions
GenBank Protein ID33918
UniProtKB IDP02778
UniProtKB Entry NameCXL10_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0016257|C-X-C motif chemokine 10 (CXCL10)
ATGAATCAAACTGCCATTCTGATTTGCTGCCTTATCTTTCTGACTCTAAGTGGCATTCAA
GGAGTACCTCTCTCTAGAACTGTACGCTGTACCTGCATCAGCATTAGTAATCAACCTGTT
AATCCAAGGTCTTTAGAAAAACTTGAAATTATTCCTGCAAGCCAATTTTGTCCACGTGTT
GAGATCATTGCTACAATGAAAAAGAAGGGTGAGAAGAGATGTCTGAATCCAGAATCGAAG
GCCATCAAGAATTTACTGAAAGCAGTTAGCAAGGAAAGGTCTAAAAGATCTCCTTAA
GenBank Gene IDX02530
GeneCard IDNone
GenAtlas IDCXCL10
HGNC IDHGNC:10637
Chromosome Location4
Locus4q21
References
  1. Luster AD, Unkeless JC, Ravetch JV: Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature. 1985 Jun 20-26;315(6021):672-6.[3925348 ]
  2. Proost P, De Wolf-Peeters C, Conings R, Opdenakker G, Billiau A, Van Damme J: Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. J Immunol. 1993 Feb 1;150(3):1000-10.[8423327 ]
  3. Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R: Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). J Invest Dermatol. 1999 May;112(5):716-22.[10233762 ]
  4. Hensbergen PJ, van der Raaij-Helmer EM, Dijkman R, van der Schors RC, Werner-Felmayer G, Boorsma DM, Scheper RJ, Willemze R, Tensen CP: Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity. Eur J Biochem. 2001 Sep;268(18):4992-9.[11559369 ]
  5. Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts JP, Van Damme J, Proost P: Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood. 2008 Oct 1;112(7):2648-56. doi: 10.1182/blood-2008-04-149039. Epub 2008 Jul 21.[18645041 ]
  6. Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD: The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 2002 Aug 20;41(33):10418-25.[12173928 ]
  7. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]

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FRCD ID Name Exact Mass Structure




F05111



Myclobutanil


288.779




F05437



Pyrimethanil


199.257




F03447



(±)-Naled


380.778




F04043



Resmethrin


338.447




F03774



Bisphenol A


228.291




F03890



Fipronil


437.141




F03962



Benomyl


290.323




F04084



Butachlor


311.85




F04333



Chlorothalonil


265.902




F05401



Cyazofamid


324.783




F05035



Bromacil


261.119




F05037



Captan


300.578




F05034



Boscalid


343.207




F05036



Butafenacil


474.817




F05042



Chlorsulfuron


357.769




F05053



Dazomet


162.269




F05054



Dichloran


207.01




F05057



Dicrotophos


237.192




F05064



Etoxazole


359.417




F05071



Fluazinam


465.089




F05080



Folpet


296.546




F05081



Fosthiazate


283.341




F05085



Enilconazole


297.179




F05094



Lactofen


461.774




F05105



Metribuzin


214.287




F05091



Iprodione


330.165




F05092



Isoxaben


332.4




F05093



Isoxaflutole


359.319




F05104



Methoxyfenozide


368.477




F05112



Napropamide


271.36




F05113



Niclosamide


327.117




F05125



Propargite


350.473




F05130



Pyraclostrobin


387.82




F05807



Sethoxydim


327.483




F05136



Simazine


201.658




F05137



Spiroxamine


297.483




F05140



Tebufenpyrad


333.86




F05151



Triclosan


289.536




F05141



Tebupirimfos


318.372




F05144



Thiabendazole


201.247




F05148



Triasulfuron


401.822




F05388



Atrazine


215.685




F05392



Butylate


217.371




F05393



Captafol


349.047




F05405



Diazoxon


288.284




F05419



Fluometuron


232.206




F05428



Novaluron


492.706




F05440



Rimsulfuron


431.438




F05445



Thiram


240.416




F05452



Zoxamide


336.637