Osteocalcin
Name | Osteocalcin |
---|---|
Synonyms | BGP Bone Gla protein Gamma-carboxyglutamic acid-containing protein |
Gene Name | BGLAP |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0020481|Osteocalcin MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAP VPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV |
Number of residues | 100 |
Molecular Weight | 10962.445 |
Theoretical pI | 7.18 |
GO Classification |
Functions
structural constituent of bone hydroxyapatite binding structural molecule activity calcium ion binding Processes
regulation of bone resorption response to mechanical stimulus response to gravity regulation of bone mineralization response to ethanol regulation of osteoclast differentiation response to zinc ion cell aging osteoblast differentiation bone mineralization skeletal system development cellular response to growth factor stimulus response to vitamin K response to activity response to vitamin D cell adhesion response to estrogen osteoblast development cellular response to vitamin D response to glucocorticoid response to testosterone response to hydroxyisoflavone odontogenesis response to drug bone development Components
extracellular space Golgi apparatus rough endoplasmic reticulum membrane-bounded vesicle dendrite cytoplasm perikaryon |
General Function | Structural molecule activity |
Specific Function | Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. |
Transmembrane Regions | |
GenBank Protein ID | 36093 |
UniProtKB ID | P02818 |
UniProtKB Entry Name | OSTCN_HUMAN |
Cellular Location | Secreted |
Gene sequence | >lcl|BSEQ0020482|Osteocalcin (BGLAP) ATGAGAGCCCTCACACTCCTCGCCCTATTGGCCCTGGCCGCACTTTGCATCGCTGGCCAG GCAGGTGCGAAGCCCAGCGGTGCAGAGTCCAGCAAAGGTGCAGCCTTTGTGTCCAAGCAG GAGGGCAGCGAGGTAGTGAAGAGACCCAGGCGCTACCTGTATCAATGGCTGGGAGCCCCA GTCCCCTACCCGGATCCCCTGGAGCCCAGGAGGGAGGTGTGTGAGCTCAATCCGGACTGT GACGAGTTGGCTGACCACATCGGCTTTCAGGAGGCCTATCGGCGCTTCTACGGCCCGGTC TAG |
GenBank Gene ID | X53698 |
GeneCard ID | None |
GenAtlas ID | BGLAP |
HGNC ID | HGNC:1043 |
Chromosome Location | 1 |
Locus | 1q25-q31 |
References |
|
Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Menadione |
172.183 |
||
Phytonadione |
450.707 |