Cytochrome P450 1A1

NameCytochrome P450 1A1
Synonyms1.14.14.1 CYPIA1 Cytochrome P450 form 6 Cytochrome P450-C Cytochrome P450-P1
Gene NameCYP1A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006827|Cytochrome P450 1A1
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
Number of residues512
Molecular Weight58164.815
Theoretical pI8.47
GO Classification
Functions
    steroid hydroxylase activity
oxidoreductase activity
flavonoid 3'-monooxygenase activity
iron ion binding
oxidoreductase activity, acting on diphenols and related substances as donors
heme binding
vitamin D 24-hydroxylase activity
monooxygenase activity
aromatase activity
oxygen binding
demethylase activity
Processes
    arachidonic acid metabolic process
response to nematode
vitamin D metabolic process
small molecule metabolic process
drug metabolic process
cellular response to organic cyclic compound
response to hyperoxia
aging
digestive tract development
oxidation-reduction process
response to herbicide
maternal process involved in parturition
response to hypoxia
response to vitamin A
epoxygenase P450 pathway
response to wounding
9-cis-retinoic acid biosynthetic process
response to virus
amine metabolic process
response to lipopolysaccharide
coumarin metabolic process
porphyrin-containing compound metabolic process
response to drug
dibenzo-p-dioxin catabolic process
cellular lipid metabolic process
response to arsenic-containing substance
response to antibiotic
flavonoid metabolic process
embryo development ending in birth or egg hatching
response to immobilization stress
camera-type eye development
insecticide metabolic process
response to food
hepatocyte differentiation
hydrogen peroxide biosynthetic process
response to iron(III) ion
xenobiotic metabolic process
positive regulation of G1/S transition of mitotic cell cycle
cell proliferation
omega-hydroxylase P450 pathway
Components
    mitochondrion
endoplasmic reticulum membrane
General FunctionVitamin d 24-hydroxylase activity
Specific FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Transmembrane Regions
GenBank Protein ID181276
UniProtKB IDP04798
UniProtKB Entry NameCP1A1_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0012466|Cytochrome P450 1A1 (CYP1A1)
ATGCTTTTCCCAATCTCCATGTCGGCCACGGAGTTTCTTCTGGCCTCTGTCATCTTCTGT
CTGGTATTCTGGGTAATCAGGGCCTCAAGACCTCAGGTCCCCAAAGGCCTGAAGAATCCA
CCAGGGCCATGGGGCTGGCCTCTGATTGGGCACATGCTGACCCTGGGAAAGAACCCGCAC
CTGGCACTGTCAAGGATGAGCCAGCAGTATGGGGACGTGCTGCAGATCCGAATTGGCTCC
ACACCCGTGGTGGTGCTGAGCGGCCTGGACACCATCCGGCAGGCCCTGGTGCGGCAGGGC
GATGATTTCAAGGGCCGGCCCGACCTCTACACCTTCACCCTCATCAGTAATGGTCAGAGC
ATGTCCTTCAGCCCAGACTCTGGACCAGTGTGGGCTGCCCGCCGGCGCCTGGCCCAGAAT
GGCCTGAAAAGTTTCTCCATTGCCTCTGACCCAGCCTCCTCAACCTCCTGCTACCTGGAA
GAGCATGTGAGCAAGGAGGCTGAGGTCCTGATAAGCACGTTGCAGGAGCTGATGGCAGGG
CCTGGGCACTTTAACCCCTACAGGTATGTGGTGGTATCAGTGACCAATGTCATCTGTGCC
ATTTGCTTTGGCCGGCGCTATGACCACAACCACCAAGAACTGCTTAGCCTAGTCAACCTG
AATAATAATTTCGGGGAGGTGGTTGGCTCTGGAAACCCAGCTGACTTCATCCCTATTCTT
CGCTACCTACCCAACCCTTCCCTGAATGCCTTCAAGGACCTGAATGAGAAGTTCTACAGC
TTCATGCAGAAGATGGTCAAGGAGCACTACAAAACCTTTGAGAAGGGCCACATCCGGGAC
ATCACAGACAGCCTGATTGAGCACTGTCAGGAGAAGCAGCTGGATGAGAACGCCAATGTC
CAGCTGTCAGATGAGAAGATCATTAACATCGTCTTGGACCTCTTTGGAGCTGGGTTTGAC
ACAGTCACAACTGCTATCTCCTGGAGCCTCATGTATTTGGTGATGAACCCCAGGGTACAG
AGAAAGATCCAAGAGGAGCTAGACACAGTGATTGGCAGGTCACGGCGGCCCCGGCTCTCT
GACAGATCCCATCTGCCCTATATGGAGGCCTTCATCCTGGAGACCTTCCGACACTCTTCC
TTCGTCCCCTTCACCATCCCCCACAGCACAACAAGAGACACAAGTTTGAAAGGCTTTTAC
ATCCCCAAGGGGCGTTGTGTCTTTGTAAACCAGTGGCAGATCAACCATGACCAGAAGCTA
TGGGTCAACCCATCTGAGTTCCTACCTGAACGGTTTCTCACCCCTGATGGTGCTATCGAC
AAGGTGTTAAGTGAGAAGGTGATTATCTTTGGCATGGGCAAGCGGAAGTGTATCGGTGAG
ACCATTGCCCGCTGGGAGGTCTTTCTCTTCCTGGCTATCCTGCTGCAACGGGTGGAATTC
AGCGTGCCACTGGGCGTGAAGGTGGACATGACCCCCATCTATGGGCTAACCATGAAGCAT
GCCTGCTGTGAGCACTTCCAAATGCAGCTGCGCTCTTAG
GenBank Gene IDK03191
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:2595
Chromosome Location15
Locus15q24.1
References
  1. Chevalier D, Allorge D, Lo-Guidice JM, Cauffiez C, Lhermitte M, Lafitte JJ, Broly F: Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population. Hum Mutat. 2001 Apr;17(4):355.[11295847 ]
  2. Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW: Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Hum Mutat. 2005 Feb;25(2):196-206.[15643613 ]
  3. Jaiswal AK, Gonzalez FJ, Nebert DW: Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. Nucleic Acids Res. 1985 Jun 25;13(12):4503-20.[2989797 ]
  4. Jaiswal AK, Gonzalez FJ, Nebert DW: Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. Science. 1985 Apr 5;228(4695):80-3.[3838385 ]
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  9. Yun CH, Park HJ, Kim SJ, Kim HK: Identification of cytochrome P450 1A1 in human brain. Biochem Biophys Res Commun. 1998 Feb 24;243(3):808-10.[9500998 ]
  10. Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH: Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. DNA. 1985 Oct;4(5):395-400.[3000715 ]
  11. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22.[24275569 ]
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Related FRC

FRCD ID Name Exact Mass Structure




F03440



Phorate


260.4




F03774



Bisphenol A


228.291




F05054



Dichloran


207.01




F05062



Ethalfluralin


333.267




F05065



Fenamidone


311.403




F05143



Tetraconazole


372.145




F05416



Fenarimol


331.196




F05426



Linuron


249.091




F05446



Triadimefon


293.751




F05584



Apigenin


270.24




F03312



Diazinon


304.35




F03315



Methoxychlor


345.644




F03378



Guthion


317.318




F03386



Dicofol


370.475




F03387



Parathion


291.258




F03460



Pyrene


202.256




F03879



Ethanol


46.07




F03892



Rotenone


394.423




F03901



Acetochlor


269.769




F03929



Pendimethalin


281.312




F03962



Benomyl


290.323




F03972



Carbaril


201.225




F03981



Chlorpropham


213.661




F04019



Pirimicarb


238.291




F04050



Cypermethrin


416.298




F04084



Butachlor


311.85




F04086



Metolachlor


283.796




F04158



Hydroxytriphenylstannane


367.035




F04721



Acetaminophen


151.165




F04999



Emodin


270.24




F05026



Ametryn


227.33




F05680



Amitraz


293.414




F05030



Benfluralin


335.283




F05031



Bensulide


397.503




F05032



Bifenazate


300.358




F05034



Boscalid


343.207




F05040



Chloroneb


207.05




F05051



Cyprodinil


225.295




F05058



Difenoconazole


406.263




F05066



Fenamiphos


303.36




F05068



Fenitrothion


277.24




F05071



Fluazinam


465.089




F05078



Flusilazole


315.399




F05079



Flutolanil


323.315




F05085



Enilconazole


297.179




F05089



Indoxacarb


527.837




F05091



Iprodione


330.165




F05092



Isoxaben


332.4




F05094



Lactofen


461.774




F05095



Malathion


330.35




F05103



Methidathion


302.318




F05111



Myclobutanil


288.779




F05112



Napropamide


271.36




F05113



Niclosamide


327.117




F05114



Norflurazon


303.669




F05115



Oxadiazon


345.22




F05121



Phosalone


367.799




F05123



Prochloraz


376.662




F05124



Prometryn


241.357




F05125



Propargite


350.473




F05126



Propazine


229.712




F05127



Propiconazole


342.22




F05130



Pyraclostrobin


387.82




F05136



Simazine


201.658




F05140



Tebufenpyrad


333.86




F05139



Tebufenozide


352.478




F05141



Tebupirimfos


318.372




F05144



Thiabendazole


201.247




F05388



Atrazine


215.685




F05391



Butralin


295.339




F05399



Clopyralid


191.995




F05400



Coumaphos


362.761




F05401



Cyazofamid


324.783




F05403



Cyproconazole


291.779




F05410



Dithiopyr


401.41




F05415



Famoxadone


374.396




F05417



Fenbuconazole


336.823




F05418



Fludioxonil


248.189




F05419



Fluometuron


232.206




F05421



Forchlorfenuron


247.682




F05422



Hexaconazole


314.21




F05425



Isazofos


313.737




F05437



Pyrimethanil


199.257




F05438



Quinoxyfen


308.133




F05439



Quintozene


295.321




F05440



Rimsulfuron


431.438




F05443



Terbacil


216.665




F05444



Thidiazuron


220.25




F05447



Triadimenol


295.767




F06003



Triflumizole


345.75




F05450



Trifluralin


335.283




F05451



Triticonazole


317.817