Plasminogen activator inhibitor 1


NamePlasminogen activator inhibitor 1
SynonymsEndothelial plasminogen activator inhibitor PAI PAI1 PLANH1 Serpin E1
Gene NameSERPINE1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000479|Plasminogen activator inhibitor 1
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
Number of residues402
Molecular Weight45059.695
Theoretical pI7.22
GO Classification
Functions
    protease binding
    receptor binding
    serine-type endopeptidase inhibitor activity
Processes
    gene expression
    positive regulation of receptor-mediated endocytosis
    positive regulation of inflammatory response
    negative regulation of endothelial cell apoptotic process
    transcription initiation from RNA polymerase II promoter
    regulation of receptor activity
    circadian rhythm
    negative regulation of plasminogen activation
    transcription, DNA-templated
    angiogenesis
    negative regulation of smooth muscle cell migration
    extracellular matrix organization
    transforming growth factor beta receptor signaling pathway
    cellular response to lipopolysaccharide
    blood coagulation
    negative regulation of smooth muscle cell-matrix adhesion
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
    negative regulation of endopeptidase activity
    negative regulation of vascular wound healing
    positive regulation of transcription from RNA polymerase II promoter
    negative regulation of wound healing
    chronological cell aging
    positive regulation of angiogenesis
    platelet degranulation
    defense response to Gram-negative bacterium
    positive regulation of interleukin-8 production
    fibrinolysis
    negative regulation of blood coagulation
    positive regulation of leukotriene production involved in inflammatory response
    negative regulation of fibrinolysis
    negative regulation of cell adhesion mediated by integrin
    platelet activation
    positive regulation of monocyte chemotaxis
    positive regulation of blood coagulation
    negative regulation of cell migration
Components
    extracellular exosome
    extracellular matrix
    extracellular region
    platelet alpha granule lumen
    plasma membrane
    extracellular space
General FunctionSerine-type endopeptidase inhibitor activity
Specific FunctionSerine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Transmembrane Regions
GenBank Protein ID35272
UniProtKB IDP05121
UniProtKB Entry NamePAI1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010214|Plasminogen activator inhibitor 1 (SERPINE1)
ATGCAGATGTCTCCAGCCCTCACCTGCCTAGTCCTGGGCCTGGCCCTTGTCTTTGGTGAA
GGGTCTGCTGTGCACCATCCCCCATCCTACGTGGCCCACCTGGCCTCAGACTTCGGGGTG
AGGGTGTTTCAGCAGGTGGCGCAGGCCTCCAAGGACCGCAACGTGGTTTTCTCACCCTAT
GGGGTGGCCTCGGTGTTGGCCATGCTCCAGCTGACAACAGGAGGAGAAACCCAGCAGCAG
ATTCAAGCAGCTATGGGATTCAAGATTGATGACAAGGGCATGGCCCCCGCCCTCCGGCAT
CTGTACAAGGAGCTCATGGGGCCATGGAACAAGGATGAGATCAGCACCACAGACGCGATC
TTCGTCCAGCGGGATCTGAAGCTGGTCCAGGGCTTCATGCCCCACTTCTTCAGGCTGTTC
CGGAGCACGGTCAAGCAAGTGGACTTTTCAGAGGTGGAGAGAGCCAGATTCATCATCAAT
GACTGGGTGAAGACACACACAAAAGGTATGATCAGCAACTTGCTTGGGAAAGGAGCCGTG
GACCAGCTGACACGGCTGGTGCTGGTGAATGCCCTCTACTTCAACGGCCAGTGGAAGACT
CCCTTCCCCGACTCCAGCACCCACCGCCGCCTCTTCCACAAATCAGACGGCAGCACTGTC
TCTGTGCCCATGATGGCTCAGACCAACAAGTTCAACTATACTGAGTTCACCACGCCCGAT
GGCCATTACTACGACATCCTGGAACTGCCCTACCACGGGGACACCCTCAGCATGTTCATT
GCTGCCCCTTATGAAAAAGAGGTGCCTCTCTCTGCCCTCACCAACATTCTGAGTGCCCAG
CTCATCAGCCACTGGAAAGGCAACATGACCAGGCTGCCCCGCCTCCTGGTTCTGCCCAAG
TTCTCCCTGGAGACTGAAGTCGACCTCAGGAAGCCCCTAGAGAACCTGGGAATGACCGAC
ATGTTCAGACAGTTTCAGGCTGACTTCACGAGTCTTTCAGACCAAGAGCCTCTCCACGTC
GCGCAGGCGCTGCAGAAAGTGAAGATCGAGGTGAACGAGAGTGGCACGGTGGCCTCCTCA
TCCACAGCTGTCATAGTCTCAGCCCGCATGGCCCCCGAGGAGATCATCATGGACAGACCC
TTCCTCTTTGTGGTCCGGCACAACCCCACAGGAACAGTCCTTTTCATGGGCCAAGTGATG
GAACCCTGA
GenBank Gene IDX04429
GeneCard IDNone
GenAtlas IDSERPINE1
HGNC IDHGNC:8583
Chromosome Location7
Locus7q21.3-q22
References
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