Interleukin-6
Name | Interleukin-6 |
---|---|
Synonyms | B-cell stimulatory factor 2 BSF-2 CDF CTL differentiation factor Hybridoma growth factor IFN-beta-2 IFNB2 IL-6 Interferon beta-2 |
Gene Name | IL6 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0021838|Interleukin-6 MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM |
Number of residues | 212 |
Molecular Weight | 23717.965 |
Theoretical pI | 6.52 |
GO Classification |
Functions
cytokine activity interleukin-6 receptor binding growth factor activity Processes
acute-phase response positive regulation of B cell activation positive regulation of transmission of nerve impulse neuron projection development positive regulation of apoptotic process aging defense response to virus positive regulation of cell proliferation negative regulation of cytokine secretion negative regulation of chemokine biosynthetic process hepatic immune response positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation cellular response to dexamethasone stimulus positive regulation of JAK-STAT cascade positive regulation of interleukin-6 production negative regulation of lipid storage response to yeast negative regulation of collagen biosynthetic process humoral immune response positive regulation of ERK1 and ERK2 cascade cellular response to hydrogen peroxide defense response to protozoan response to calcium ion response to auditory stimulus positive regulation of translation glucagon secretion inflammatory response positive regulation of smooth muscle cell proliferation cellular response to tumor necrosis factor response to electrical stimulus cellular response to interleukin-1 response to glucocorticoid monocyte chemotaxis positive regulation of protein import into nucleus, translocation positive regulation of nitric oxide biosynthetic process negative regulation of muscle organ development positive regulation of neuron differentiation positive regulation of transcription, DNA-templated response to caffeine negative regulation of neuron death negative regulation of gluconeogenesis response to nutrient levels endocrine pancreas development neutrophil apoptotic process positive regulation of type B pancreatic cell apoptotic process cell growth response to amino acid negative regulation of apoptotic process negative regulation of hormone secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of T-helper 2 cell differentiation cellular response to lipopolysaccharide response to heat regulation of angiogenesis branching involved in salivary gland morphogenesis T-helper 17 cell lineage commitment regulation of cell shape negative regulation of cell proliferation positive regulation of MAPK cascade regulation of vascular endothelial growth factor production response to peptidoglycan bone remodeling positive regulation of tyrosine phosphorylation of Stat3 protein defense response to Gram-negative bacterium epithelial cell proliferation involved in salivary gland morphogenesis platelet activation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of STAT protein import into nucleus negative regulation of fat cell differentiation response to drug cytokine-mediated signaling pathway response to cold positive regulation of chemokine production regulation of circadian sleep/wake cycle, non-REM sleep cell redox homeostasis positive regulation of peptidyl-serine phosphorylation positive regulation of leukocyte chemotaxis positive regulation of protein kinase B signaling neutrophil mediated immunity response to antibiotic positive regulation of DNA replication positive regulation of T cell proliferation muscle cell cellular homeostasis negative regulation of protein kinase activity positive regulation of transcription from RNA polymerase II promoter positive regulation of acute inflammatory response positive regulation of immunoglobulin secretion interleukin-6-mediated signaling pathway response to insulin glucose homeostasis positive regulation of osteoblast differentiation defense response to Gram-positive bacterium Components
interleukin-6 receptor complex extracellular space external side of plasma membrane cytoplasm extracellular region |
General Function | Interleukin-6 receptor binding |
Specific Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
Transmembrane Regions | |
GenBank Protein ID | 32674 |
UniProtKB ID | P05231 |
UniProtKB Entry Name | IL6_HUMAN |
Cellular Location | Secreted |
Gene sequence | >lcl|BSEQ0021839|Interleukin-6 (IL6) ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC AGAGCTGTGCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG |
GenBank Gene ID | X04430 |
GeneCard ID | None |
GenAtlas ID | IL6 |
HGNC ID | HGNC:6018 |
Chromosome Location | 7 |
Locus | 7p21 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Chlorothalonil |
265.902 |
||
Fluazinam |
465.089 |
||
Niclosamide |
327.117 |