Transcription factor AP-1

NameTranscription factor AP-1
SynonymsActivator protein 1 AP1 p39 Proto-oncogene c-Jun V-jun avian sarcoma virus 17 oncogene homolog
Gene NameJUN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016292|Transcription factor AP-1
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Number of residues331
Molecular Weight35675.32
Theoretical pI9.11
GO Classification
Functions
    cAMP response element binding
transcription factor binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription factor binding
R-SMAD binding
enzyme binding
poly(A) RNA binding
RNA polymerase II activating transcription factor binding
GTPase activator activity
transcription regulatory region DNA binding
transcription coactivator activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
RNA polymerase II distal enhancer sequence-specific DNA binding
Processes
    positive regulation of DNA replication
negative regulation of neuron apoptotic process
response to cAMP
MyD88-dependent toll-like receptor signaling pathway
learning
leading edge cell differentiation
response to radiation
response to hydrogen peroxide
MyD88-independent toll-like receptor signaling pathway
cellular response to calcium ion
microglial cell activation
negative regulation of cell proliferation
regulation of sequence-specific DNA binding transcription factor activity
negative regulation by host of viral transcription
membrane depolarization
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
stress-activated MAPK cascade
outflow tract morphogenesis
positive regulation of smooth muscle cell proliferation
toll-like receptor 4 signaling pathway
positive regulation by host of viral transcription
cellular response to potassium ion starvation
response to muscle stretch
toll-like receptor 10 signaling pathway
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
response to mechanical stimulus
toll-like receptor 5 signaling pathway
positive regulation of DNA-templated transcription, initiation
circadian rhythm
toll-like receptor 2 signaling pathway
negative regulation of protein autophosphorylation
regulation of cell death
liver development
toll-like receptor 9 signaling pathway
axon regeneration
release of cytochrome c from mitochondria
cellular response to hormone stimulus
toll-like receptor 3 signaling pathway
SMAD protein signal transduction
transforming growth factor beta receptor signaling pathway
toll-like receptor signaling pathway
positive regulation of cell differentiation
innate immune response
response to lipopolysaccharide
SMAD protein import into nucleus
response to drug
aging
toll-like receptor TLR1
positive regulation of monocyte differentiation
regulation of cell proliferation
positive regulation of GTPase activity
negative regulation of DNA binding
toll-like receptor TLR6
regulation of cell cycle
positive regulation of endothelial cell proliferation
positive regulation of neuron apoptotic process
positive regulation of fibroblast proliferation
Fc-epsilon receptor signaling pathway
angiogenesis
TRIF-dependent toll-like receptor signaling pathway
response to cytokine
positive regulation of transcription, DNA-templated
monocyte differentiation
Components
    nuclear euchromatin
transcription factor complex
cytosol
transcriptional repressor complex
nucleoplasm
nucleus
nuclear chromosome
General FunctionTranscriptional activator activity, rna polymerase ii transcription factor binding
Specific FunctionTranscription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Transmembrane Regions
GenBank Protein ID386839
UniProtKB IDP05412
UniProtKB Entry NameJUN_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016293|Transcription factor AP-1 (JUN)
ATGACTGCAAAGATGGAAACGACCTTCTATGACGATGCCCTCAACGCCTCGTTCCTCCCG
TCCGAGAGCGGACCTTATGGCTACAGTAACCCCAAGATCCTGAAACAGAGCATGACCCTG
AACCTGGCCGACCCAGTGGGGAGCCTGAAGCCGCACCTCCGCGCCAAGAACTCGGACCTC
CTCACCTCGCCCGACGTGGGGCTGCTCAAGCTGGCGTCGCCCGAGCTGGAGCGCCTGATA
ATCCAGTCCAGCAACGGGCACATCACCACCACGCCGACCCCCACCCAGTTCCTGTGCCCC
AAGAACGTGACAGATGAGCAGGAGGGCTTCGCCGAGGGCTTCGTGCGCGCCCTGGCCGAA
CTGCACAGCCAGAACACGCTGCCCAGCGTCACGTCGGCGGCGCAGCCGGTCAACGGGGCA
GGCATGGTGGCTCCCGCGGTAGCCTCGGTGGCAGGGGGCAGCGGCAGCGGCGGCTTCAGC
GCCAGCCTGCACAGCGAGCCGCCGGTCTACGCAAACCTCAGCAACTTCAACCCAGGCGCG
CTGAGCAGCGGCGGCGGGGCGCCCTCCTACGGCGCGGCCGGCCTGGCCTTTCCCGCGCAA
CCCCAGCAGCAGCAGCAGCCGCCGCACCACCTGCCCCAGCAGATGCCCGTGCAGCACCCG
CGGCTGCAGGCCCTGAAGGAGGAGCCTCAGACAGTGCCCGAGATGCCCGGCGAGACACCG
CCCCTGTCCCCCATCGACATGGAGTCCCAGGAGCGGATCAAGGCGGAGAGGAAGCGCATG
AGGAACCGCATCGCTGCCTCCAAGTGCCGAAAAAGGAAGCTGGAGAGAATCGCCCGGCTG
GAGGAAAAAGTGAAAACCTTGAAAGCTCAGAACTCGGAGCTGGCGTCCACGGCCAACATG
CTCAGGGAACAGGTGGCACAGCTTAAACAGAAAGTCATGAACCACGTTAACAGTGGGTGC
CAACTCATGCTAACGCAGCAGTTGCAAACATTTTGA
GenBank Gene IDJ04111
GeneCard IDNone
GenAtlas IDJUN
HGNC IDHGNC:6204
Chromosome Location1
Locus1p32-p31
References
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