Glutathione peroxidase 1
Name | Glutathione peroxidase 1 |
---|---|
Synonyms | 1.11.1.9 Cellular glutathione peroxidase GPx-1 |
Gene Name | GPX1 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037083|Glutathione peroxidase 1 MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMN ELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGA GAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYS RRFQTIDIEPDIEALLSQGPSCA |
Number of residues | 203 |
Molecular Weight | 22087.94 |
Theoretical pI | 6.5 |
GO Classification |
Functions
SH3 domain binding phospholipid-hydroperoxide glutathione peroxidase activity glutathione binding glutathione peroxidase activity selenium binding Processes
response to glucose blood vessel endothelial cell migration protein oxidation response to toxic substance heart contraction hydrogen peroxide catabolic process regulation of gene expression, epigenetic endothelial cell development regulation of neuron apoptotic process positive regulation of fibril organization positive regulation of protein kinase B signaling vasodilation interaction with symbiont arachidonic acid metabolic process response to xenobiotic stimulus angiogenesis involved in wound healing regulation of mammary gland epithelial cell proliferation cellular response to oxidative stress myoblast proliferation lipoxygenase pathway skeletal muscle fiber development response to folic acid response to symbiotic bacterium response to estradiol negative regulation of release of cytochrome c from mitochondria purine nucleotide catabolic process negative regulation of inflammatory response to antigenic stimulus response to gamma radiation response to hydrogen peroxide aging triglyceride metabolic process sensory perception of sound fat cell differentiation response to selenium ion negative regulation of cysteine-type endopeptidase activity involved in apoptotic process intrinsic apoptotic signaling pathway in response to oxidative stress response to nicotine response to reactive oxygen species negative regulation of extrinsic apoptotic signaling pathway via death domain receptors UV protection temperature homeostasis cell redox homeostasis nucleobase-containing small molecule metabolic process regulation of proteasomal protein catabolic process glutathione metabolic process small molecule metabolic process response to lipid hydroperoxide skeletal muscle tissue regeneration purine nucleobase metabolic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Components
cytosol extracellular exosome cytoplasm mitochondrion nucleus mitochondrial matrix |
General Function | Sh3 domain binding |
Specific Function | Protects the hemoglobin in erythrocytes from oxidative breakdown. |
Transmembrane Regions | |
GenBank Protein ID | 577777 |
UniProtKB ID | P07203 |
UniProtKB Entry Name | GPX1_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0020489|Glutathione peroxidase 1 (GPX1) ATGTGTGCTGCTCGGCTAGCGGCGGCGGCGGCGGCGGCCCAGTCGGTGTATGCCTTCTCG GCGCGCCCGCTGGCCGGCGGGGAGCCTGTGAGCCTGGGCTCCCTGCGGGGCAAGGTACTA CTTATCGAGAATGTGGCGTCCCTCTGAGGCACCACGGTCCGGGACTACACCCAGATGAAC GAGCTGCAGCGGCGCCTCGGACCCCGGGGCCTGGTGGTGCTCGGCTTCCCGTGCAACCAG TTTGGGCATCAGGAGAACGCCAAGAACGAAGAGATTCTGAATTCCCTCAAGTACGTCCGG CCTGGTGGTGGGTTCGAGCCCAACTTCATGCTCTTCGAGAAGTGCGAGGTGAACGGTGCG GGGGCGCACCCTCTCTTCGCCTTCCTGCGGGAGGCCCTGCCAGCTCCCAGCGACGACGCC ACCGCGCTTATGACCGACCCCAAGCTCATCACCTGGTCTCCGGTGTGTCGCAACGATGTT GCCTGGAACTTTGAGAAGTTCCTGGTGGGCCCTGACGGTGTGCCCCTACGCAGGTACAGC CGCCGCTTCCAGACCATTGACATCGAGCCTGACATCGAAGCCCTGCTGTCTCAAGGGCCC AGCTGTGCCTAG |
GenBank Gene ID | Y00433 |
GeneCard ID | None |
GenAtlas ID | GPX1 |
HGNC ID | HGNC:4553 |
Chromosome Location | 3 |
Locus | 3p21.3 |
References |
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