Beta-2 adrenergic receptor

NameBeta-2 adrenergic receptor
SynonymsADRB2R B2AR Beta-2 adrenoceptor Beta-2 adrenoreceptor
Gene NameADRB2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037061|Beta-2 adrenergic receptor
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Number of residues413
Molecular Weight46458.32
Theoretical pI7.44
GO Classification
Functions
    protein homodimerization activity
epinephrine binding
norepinephrine binding
drug binding
potassium channel regulator activity
dopamine binding
beta2-adrenergic receptor activity
Processes
    positive regulation of sodium ion transport
negative regulation of platelet aggregation
regulation of sensory perception of pain
response to estrogen
response to cold
cellular response to hypoxia
liver regeneration
cell-cell signaling
positive regulation of MAPK cascade
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
positive regulation of bone mineralization
endosome to lysosome transport
negative regulation of inflammatory response
mitophagy in response to mitochondrial depolarization
aging
positive regulation of ATPase activity
positive regulation of apoptotic process
positive regulation of vasodilation
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
estrous cycle
negative regulation of smooth muscle contraction
regulation of calcium ion transport
response to progesterone
negative regulation of urine volume
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
receptor-mediated endocytosis
negative regulation of ossification
synaptic transmission, glutamatergic
positive regulation of protein ubiquitination
response to testosterone
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of autophagosome maturation
activation of adenylate cyclase activity
female pregnancy
activation of transmembrane receptor protein tyrosine kinase activity
bone resorption
brown fat cell differentiation
positive regulation of lipophagy
positive regulation of transcription from RNA polymerase II promoter
diaphragm contraction
diet induced thermogenesis
positive regulation of skeletal muscle tissue growth
wound healing
associative learning
negative regulation of angiogenesis
excitatory postsynaptic potential
heat generation
positive regulation of the force of heart contraction by epinephrine
cell surface receptor signaling pathway
response to dexamethasone
positive regulation of potassium ion transport
positive regulation of cell proliferation
negative regulation of multicellular organism growth
response to monoamine
Components
    lysosome
endosome
axon
early endosome
apical plasma membrane
integral component of plasma membrane
neuronal cell body membrane
nucleus
plasma membrane
dendritic spine
receptor complex
sarcolemma
General FunctionProtein homodimerization activity
Specific FunctionBeta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Transmembrane Regions35-58 72-95 107-129 151-174 197-220 275-298 306-329
GenBank Protein ID29371
UniProtKB IDP07550
UniProtKB Entry NameADRB2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0020478|Beta-2 adrenergic receptor (ADRB2)
ATGGGGCAACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATAGAAGCCATGCGCCG
GACCACGACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATG
TCTCTCATCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAG
TTCGAGCGTCTGCAGACGGTCACCAACTACTTCATCACTTCACTGGCCTGTGCTGATCTG
GTCATGGGCCTGGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTTATGAAAATGTGGACT
TTTGGCAACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCGTCACGGCCAGC
ATTGAGACCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCAAG
TACCAGAGCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTG
TCAGGCCTTACCTCCTTCTTGCCCATTCAGATGCACTGGTACCGGGCCACCCACCAGGAA
GCCATCAACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCC
ATTGCCTCTTCCATCGTGTCCTTCTACGTTCCCCTGGTGATCATGGTCTTCGTCTACTCC
AGGGTCTTTCAGGAGGCCAAAAGGCAGCTCCAGAAGATTGACAAATCTGAGGGCCGCTTC
CATGTCCAGAACCTTAGCCAGGTGGAGCAGGATGGGCGGACGGGGCATGGACTCCGCAGA
TCTTCCAAGTTCTGCTTGAAGGAGCACAAAGCCCTCAAGACGTTAGGCATCATCATGGGC
ACTTTCACCCTCTGCTGGCTGCCCTTCTTCATCGTTAACATTGTGCATGTGATCCAGGAT
AACCTCATCCGTAAGGAAGTTTACATCCTCCTAAATTGGATAGGCTATGTCAATTCTGGT
TTCAATCCCCTTATCTACTGCCGGAGCCCAGATTTCAGGATTGCCTTCCAGGAGCTTCTG
TGCCTGCGCAGGTCTTCTTTGAAGGCCTATGGGAATGGCTACTCCAGCAACGGCAACACA
GGGGAGCAGAGTGGATATCACGTGGAACAGGAGAAAGAAAATAAACTGCTGTGTGAAGAC
CTCCCAGGCACGGAAGACTTTGTGGGCCATCAAGGTACTGTGCCTAGCGATAACATTGAT
TCACAAGGGAGGAATTGTAGTACAAATGACTCACTGCTGTAA
GenBank Gene IDY00106
GeneCard IDNone
GenAtlas IDADRB2
HGNC IDHGNC:286
Chromosome Location5
Locus5q31-q32
References
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