Receptor-type tyrosine-protein phosphatase C

NameReceptor-type tyrosine-protein phosphatase C
Synonyms3.1.3.48 CD45 L-CA Leukocyte common antigen T200
Gene NamePTPRC
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009279|Receptor-type tyrosine-protein phosphatase C
MYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPAST
FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGT
DTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPA
RTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYN
KETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPG
VEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPE
HEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNF
TLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKS
APPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVK
DLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIY
DLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPR
VFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKY
IAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVK
INQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFS
NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQY
ILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI
GNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASF
IMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQT
YGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQ
VVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVK
ALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCV
NPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Number of residues1304
Molecular Weight147253.075
Theoretical pINone
GO Classification
Functions
    transmembrane receptor protein tyrosine phosphatase activity
protein kinase binding
protein tyrosine phosphatase activity
Processes
    hematopoietic progenitor cell differentiation
positive regulation of stem cell proliferation
positive regulation of T cell proliferation
negative regulation of protein kinase activity
stem cell development
T cell receptor signaling pathway
negative regulation of cell adhesion involved in substrate-bound cell migration
protein dephosphorylation
negative regulation of cytokine-mediated signaling pathway
axon guidance
release of sequestered calcium ion into cytosol
T cell differentiation
dephosphorylation
bone marrow development
positive regulation of B cell proliferation
cell cycle phase transition
cell surface receptor signaling pathway
positive regulation of protein kinase activity
immunoglobulin biosynthetic process
B cell proliferation
B cell receptor signaling pathway
negative regulation of T cell mediated cytotoxicity
defense response to virus
regulation of cell cycle
positive regulation of antigen receptor-mediated signaling pathway
peptidyl-tyrosine dephosphorylation
positive regulation of hematopoietic stem cell migration
Components
    cell surface
extracellular exosome
external side of plasma membrane
integral component of plasma membrane
intracellular
membrane
plasma membrane
membrane raft
focal adhesion
General FunctionTransmembrane receptor protein tyrosine phosphatase activity
Specific FunctionProtein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Transmembrane Regions576-597
GenBank Protein ID
UniProtKB IDP08575
UniProtKB Entry NamePTPRC_HUMAN
Cellular LocationMembrane
Gene sequence
None
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:9666
Chromosome LocationNone
LocusNone
References
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  2. Streuli M, Hall LR, Saga Y, Schlossman SF, Saito H: Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens. J Exp Med. 1987 Nov 1;166(5):1548-66.[2824653 ]
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  4. Tsai AY, Streuli M, Saito H: Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA. Mol Cell Biol. 1989 Oct;9(10):4550-5.[2531281 ]
  5. Hall LR, Streuli M, Schlossman SF, Saito H: Complete exon-intron organization of the human leukocyte common antigen (CD45) gene. J Immunol. 1988 Oct 15;141(8):2781-7.[2971730 ]
  6. Charbonneau H, Tonks NK, Walsh KA, Fischer EH: The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7182-6.[2845400 ]
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  11. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012.[19159218 ]
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  18. Tchilian EZ, Wallace DL, Wells RS, Flower DR, Morgan G, Beverley PC: A deletion in the gene encoding the CD45 antigen in a patient with SCID. J Immunol. 2001 Jan 15;166(2):1308-13.[11145714 ]
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