Fibroblast growth factor 4

NameFibroblast growth factor 4
SynonymsFGF-4 HBGF-4 Heparin secretory-transforming protein 1 Heparin-binding growth factor 4 HST HST-1 HSTF-1 HSTF1 KS3 Transforming protein KS3
Gene NameFGF4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000649|Fibroblast growth factor 4
MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPV
AAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSP
VERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIA
LSKNGKTKKGNRVSPTMKVTHFLPRL
Number of residues206
Molecular Weight22047.355
Theoretical pI10.19
GO Classification
Functions
    heparin binding
growth factor activity
Processes
    odontogenesis of dentin-containing tooth
regulation of endothelial cell chemotaxis to fibroblast growth factor
activation of MAPKK activity
phosphatidylinositol-mediated signaling
stem cell population maintenance
fibroblast growth factor receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
signal transduction
insulin receptor signaling pathway
MAPK cascade
apoptotic process involved in morphogenesis
negative regulation of apoptotic process
cartilage condensation
small GTPase mediated signal transduction
neurotrophin TRK receptor signaling pathway
chondroblast differentiation
cell-cell signaling
positive regulation of transcription from RNA polymerase II promoter
cranial suture morphogenesis
axon guidance
Ras protein signal transduction
embryonic hindlimb morphogenesis
epidermal growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
mesenchymal cell proliferation
innate immune response
positive regulation of cell proliferation
positive regulation of cell division
Fc-epsilon receptor signaling pathway
Components
    intracellular
extracellular region
General FunctionHeparin binding
Specific FunctionPlays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
Transmembrane Regions
GenBank Protein ID386788
UniProtKB IDP08620
UniProtKB Entry NameFGF4_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0018940|Fibroblast growth factor 4 (FGF4)
ATGTCGGGGCCCGGGACGGCCGCGGTAGCGCTGCTCCCGGCGGTCCTGCTGGCCTTGCTG
GCGCCCTGGGCGGGCCGAGGGGGCGCCGCCGCACCCACTGCACCCAACGGCACGCTGGAG
GCCGAGCTGGAGCGCCGCTGGGAGAGCCTGGTGGCGCTCTCGTTGGCGCGCCTGCCGGTG
GCAGCGCAGCCCAAGGAGGCGGCCGTCCAGAGCGGCGCCGGCGACTACCTGCTGGGCATC
AAGCGGCTGCGGCGGCTCTACTGCAACGTGGGCATCGGCTTCCACCTCCAGGCGCTCCCC
GACGGCCGCATCGGCGGCGCGCACGCGGACACCCGCGACAGCCTGCTGGAGCTCTCGCCC
GTGGAGCGGGGCGTGGTGAGCATCTTCGGCGTGGCCAGCCGGTTCTTCGTGGCCATGAGC
AGCAAGGGCAAGCTCTATGGCTCGCCCTTCTTCACCGATGAGTGCACGTTCAAGGAGATT
CTCCTTCCCAACAACTACAACGCCTACGAGTCCTACAAGTACCCCGGCATGTTCATCGCC
CTGAGCAAGAATGGGAAGACCAAGAAGGGGAACCGAGTGTCGCCCACCATGAAGGTCACC
CACTTCCTCCCCAGGCTGTGA
GenBank Gene IDJ02986
GeneCard IDNone
GenAtlas IDFGF4
HGNC IDHGNC:3682
Chromosome Location11
Locus11q13.3
References
  1. Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M: Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996 Jun 21;271(25):15292-7.[8663044 ]
  2. Turner N, Grose R: Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer. 2010 Feb;10(2):116-29. doi: 10.1038/nrc2780.[20094046 ]
  3. Delli Bovi P, Curatola AM, Kern FG, Greco A, Ittmann M, Basilico C: An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell. 1987 Aug 28;50(5):729-37.[2957062 ]
  4. Mayshar Y, Rom E, Chumakov I, Kronman A, Yayon A, Benvenisty N: Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal. Stem Cells. 2008 Mar;26(3):767-74. doi: 10.1634/stemcells.2007-1037. Epub 2008 Jan 10.[18192227 ]
  5. Yoshida T, Miyagawa K, Odagiri H, Sakamoto H, Little PF, Terada M, Sugimura T: Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7305-9.[2959959 ]
  6. Taira M, Yoshida T, Miyagawa K, Sakamoto H, Terada M, Sugimura T: cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci U S A. 1987 May;84(9):2980-4.[2953031 ]
  7. Bellosta P, Iwahori A, Plotnikov AN, Eliseenkova AV, Basilico C, Mohammadi M: Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. Mol Cell Biol. 2001 Sep;21(17):5946-57.[11486033 ]

Related FRC

FRCD ID Name Exact Mass Structure




F04718



Heparin


340.31