Macrophage colony-stimulating factor 1


NameMacrophage colony-stimulating factor 1
SynonymsCSF-1 Lanimostim
Gene NameCSF1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037132|Macrophage colony-stimulating factor 1
MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQME
TSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLK
SCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSS
QDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQP
LHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPRPSVGAFNPGMEDILDSAMG
TNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPA
DVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLS
AQPQLSRSHSSGSVLPLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTDTG
HERQSEGSFSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEG
SPLTQDDRQVELPV
Number of residues554
Molecular Weight60178.885
Theoretical pI4.94
GO Classification
Functions
    protein homodimerization activity
    macrophage colony-stimulating factor receptor binding
    growth factor activity
    cytokine activity
Processes
    positive regulation of cell proliferation
    positive regulation of osteoclast differentiation
    regulation of ossification
    monocyte activation
    positive regulation of cellular protein metabolic process
    positive regulation of cell-matrix adhesion
    inflammatory response
    osteoclast proliferation
    positive regulation of macrophage derived foam cell differentiation
    positive regulation of protein kinase activity
    cell proliferation
    positive regulation of macrophage colony-stimulating factor signaling pathway
    positive regulation of gene expression
    homeostasis of number of cells within a tissue
    positive regulation of microglial cell migration
    macrophage differentiation
    positive regulation of macrophage chemotaxis
    positive regulation of monocyte differentiation
    positive regulation of multicellular organism growth
    positive regulation of macrophage differentiation
    positive regulation of mononuclear cell proliferation
    positive regulation of Ras protein signal transduction
    transmembrane receptor protein tyrosine kinase signaling pathway
    positive regulation of odontogenesis of dentin-containing tooth
    branching involved in mammary gland duct morphogenesis
    regulation of macrophage derived foam cell differentiation
    cell differentiation
    hemopoiesis
    developmental process involved in reproduction
    innate immune response
    macrophage colony-stimulating factor signaling pathway
    mammary duct terminal end bud growth
    positive regulation of cell migration
    osteoclast differentiation
    mammary gland fat development
Components
    integral component of membrane
    extracellular exosome
    membrane
    perinuclear region of cytoplasm
    CSF1-CSF1R complex
    plasma membrane
    extracellular space
General FunctionProtein homodimerization activity
Specific FunctionCytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Transmembrane Regions497-517
GenBank Protein ID181144
UniProtKB IDP09603
UniProtKB Entry NameCSF1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010809|Macrophage colony-stimulating factor 1 (CSF1)
ATGACCGCGCCGGGCGCCGCCGGGCGCTGCCCTCCCACGACATGGCTGGGCTCCCTGCTG
TTGTTGGTCTGTCTCCTGGCGAGCAGGAGTATCACCGAGGAGGTGTCGGAGTACTGTAGC
CACATGATTGGGAGTGGACACCTGCAGTCTCTGCAGCGGCTGATTGACAGTCAGATGGAG
ACCTCGTGCCAAATTACATTTGAGTTTGTAGACCAGGAACAGTTGAAAGATCCAGTGTGC
TACCTTAAGAAGGCATTTCTCCTGGTACAAGACATAATGGAGGACACCATGCGCTTCAGA
GATAACACCCCCAATGCCATCGCCATTGTGCAGCTGCAGGAACTCTCTTTGAGGCTGAAG
AGCTGCTTCACCAAGGATTATGAAGAGCATGACAAGGCCTGCGTCCGAACTTTCTATGAG
ACACCTCTCCAGTTGCTGGAGAAGGTCAAGAATGTCTTTAATGAAACAAAGAATCTCCTT
GACAAGGACTGGAATATTTTCAGCAAGAACTGCAACAACAGCTTTGCTGAATGCTCCAGC
CAAGATGTGGTGACCAAGCCTGATTGCAACTGCCTGTACCCCAAAGCCATCCCTAGCAGT
GACCCGGCCTCTGTCTCCCCTCATCAGCCCCTCGCCCCCTCCATGGCCCCTGTGGCTGGC
TTGACCTGGGAGGACTCTGAGGGAACTGAGGGCAGCTCCCTCTTGCCTGGTGAGCAGCCC
CTGCACACAGTGGATCCAGGCAGTGCCAAGCAGCGGCCACCCAGGAGCACCTGCCAGAGC
TTTGAGCCGCCAGAGACCCCAGTTGTCAAGGACAGCACCATCGGTGGCTCACCACAGCCT
CGCCCCTCTGTCGGGGCCTTCAACCCCGGGATGGAGGATATTCTTGACTCTGCAATGGGC
ACTAATTGGGTCCCAGAAGAAGCCTCTGGAGAGGCCAGTGAGATTCCCGTACCCCAAGGG
ACAGAGCTTTCCCCCTCCAGGCCAGGAGGGGGCAGCATGCAGACAGAGCCCGCCAGACCC
AGCAACTTCCTCTCAGCATCTTCTCCACTCCCTGCATCAGCAAAGGGCCAACAGCCGGCA
GATGTAACTGGTACCGCCTTGCCCAGGGTGGGCCCCGTGAGGCCCACTGGCCAGGACTGG
AATCACACCCCCCAGAAGACAGACCATCCATCTGCCCTGCTCAGAGACCCCCCGGAGCCA
GGCTCTCCCAGGATCTCATCACTGCGCCCCCAGGGCCTCAGCAACCCCTCCACCCTCTCT
GCTCAGCCACAGCTTTCCAGAAGCCACTCCTCGGGCAGCGTGCTGCCCCTTGGGGAGCTG
GAGGGCAGGAGGAGCACCAGGGATCGGAGGAGCCCCGCAGAGCCAGAAGGAGGACCAGCA
AGTGAAGGGGCAGCCAGGCCCCTGCCCCGTTTTAACTCCGTTCCTTTGACTGACACAGGC
CATGAGAGGCAGTCCGAGGGATCCTCCAGCCCGCAGCTCCAGGAGTCTGTCTTCCACCTG
CTGGTGCCCAGTGTCATCCTGGTCTTGCTGGCCGTCGGAGGCCTCTTGTTCTACAGGTGG
AGGCGGCGGAGCCATCAAGAGCCTCAGAGAGCGGATTCTCCCTTGGAGCAACCAGAGGGC
AGCCCCCTGACTCAGGATGACAGACAGGTGGAACTGCCAGTGTAG
GenBank Gene IDM11296
GeneCard IDNone
GenAtlas IDCSF1
HGNC IDHGNC:2432
Chromosome Location1
Locus1p21-p13
References
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