Interleukin-8


NameInterleukin-8
SynonymsC-X-C motif chemokine 8 Chemokine (C-X-C motif) ligand 8 Emoctakin GCP-1 Granulocyte chemotactic protein 1 IL-8 IL8 MDNCF MONAP Monocyte-derived neutrophil chemotactic factor Monocyte-derived neutrophil-activating peptide NAP-1 Neutrophil-activating protein 1 Protein 3-10C T-cell chemotactic factor
Gene NameCXCL8
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001913|Interleukin-8
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
Number of residues99
Molecular Weight11097.98
Theoretical pI9.09
GO Classification
Functions
    chemokine activity
    interleukin-8 receptor binding
Processes
    chemotaxis
    angiogenesis
    cellular response to interleukin-1
    regulation of cell adhesion
    cellular response to lipopolysaccharide
    induction of positive chemotaxis
    receptor internalization
    movement of cell or subcellular component
    negative regulation of G-protein coupled receptor protein signaling pathway
    cellular response to fibroblast growth factor stimulus
    embryonic digestive tract development
    signal transduction
    positive regulation of neutrophil chemotaxis
    cellular response to tumor necrosis factor
    endoplasmic reticulum unfolded protein response
    regulation of single stranded viral RNA replication via double stranded DNA intermediate
    cellular protein metabolic process
    PERK-mediated unfolded protein response
    immune response
    response to molecule of bacterial origin
    negative regulation of cell proliferation
    positive regulation of angiogenesis
    G-protein coupled receptor signaling pathway
    response to endoplasmic reticulum stress
    neutrophil chemotaxis
    inflammatory response
    intracellular signal transduction
    chemokine-mediated signaling pathway
    cell cycle arrest
    calcium-mediated signaling
    neutrophil activation
Components
    intracellular
    extracellular region
    extracellular space
General FunctionInterleukin-8 receptor binding
Specific FunctionIL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Transmembrane Regions
GenBank Protein ID34519
UniProtKB IDP10145
UniProtKB Entry NameIL8_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010675|Interleukin-8 (CXCL8)
ATGACTTCCAAGCTGGCCGTGGCTCTCTTGGCAGCCTTCCTGATTTCTGCAGCTCTGTGT
GAAGGTGCAGTTTTGCCAAGGAGTGCTAAAGAACTTAGATGTCAGTGCATAAAGACATAC
TCCAAACCTTTCCACCCCAAATTTATCAAAGAACTGAGAGTGATTGAGAGTGGACCACAC
TGCGCCAACACAGAAATTATTGTAAAGCTTTCTGATGGAAGAGAGCTCTGTCTGGACCCC
AAGGAAAACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGGCTGAGAATTCATAA
GenBank Gene IDY00787
GeneCard IDNone
GenAtlas IDIL8
HGNC IDHGNC:6025
Chromosome Location4
Locus4q13-q21
References
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