Cytochrome c oxidase subunit 8A, mitochondrial

NameCytochrome c oxidase subunit 8A, mitochondrial
SynonymsCOX8 COX8L Cytochrome c oxidase polypeptide VIII-liver/heart Cytochrome c oxidase subunit 8-2
Gene NameCOX8A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012781|Cytochrome c oxidase subunit 8A, mitochondrial
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILS
HLETYRRPE
Number of residues69
Molecular Weight7579.0
Theoretical pI10.83
GO Classification
Functions
    cytochrome-c oxidase activity
Processes
    respiratory electron transport chain
hydrogen ion transmembrane transport
generation of precursor metabolites and energy
positive regulation of defense response to virus by host
xenophagy
mitophagy in response to mitochondrial depolarization
mitochondrial electron transport, cytochrome c to oxygen
gene expression
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
cellular metabolic process
Components
    mitochondrial respiratory chain complex IV
mitochondrial inner membrane
integral component of membrane
General FunctionCytochrome-c oxidase activity
Specific FunctionThis protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Transmembrane Regions37-60
GenBank Protein ID38614453
UniProtKB IDP10176
UniProtKB Entry NameCOX8A_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0012782|Cytochrome c oxidase subunit 8A, mitochondrial (COX8A)
ATGTCCGTCCTGACGCCGCTGCTGCTGCGGGGCTTGACAGGCTCGGCCCGGCGGCTCCCA
GTGCCGCGCGCCAAGATCCATTCGTTGCCGCCGGAGGGGAAGCTTGGGATCATGGAATTG
GCCGTTGGGCTTACCTCCTGCTTCGTGACCTTCCTCCTGCCAGCGGGCTGGATCCTGTCA
CACCTGGAGACCTACAGGAGGCCAGAGTGA
GenBank Gene IDBC063025
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:2294
Chromosome Location11
Locus11q12-q13
References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  2. Rizzuto R, Nakase H, Darras B, Francke U, Fabrizi GM, Mengel T, Walsh F, Kadenbach B, DiMauro S, Schon EA: A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues. J Biol Chem. 1989 Jun 25;264(18):10595-600.[2543673 ]
  3. Van Kuilenburg AB, Muijsers AO, Demol H, Dekker HL, Van Beeumen JJ: Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. FEBS Lett. 1988 Nov 21;240(1-2):127-32.[2847943 ]

Related FRC

FRCD ID Name Exact Mass Structure




F03290



Cyanide


26.018




F03462



Phosphine


33.998




F03880



Methanol


32.042




F03919



Linamarin


247.247




F04323



Mandelonitrile


133.15




F04324



Acrylonitrile


53.064




F04325



Beta-Aminopropionitrile


70.095




F04326



Benzonitrile


103.124




F04327



Benzeneacetonitrile


117.151




F04329



Bromoxynil


276.915




F04332



Chlorfenapyr


407.615




F04333



Chlorothalonil


265.902




F04334



2,6-Dichlorobenzonitrile


172.008




F05174



Thallium


239.83




F02880



Zinc phosphide


264.136




F04322



Acetonitrile


41.053