Retinoic acid receptor alpha

NameRetinoic acid receptor alpha
SynonymsNR1B1 Nuclear receptor subfamily 1 group B member 1 RAR-alpha
Gene NameRARA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001322|Retinoic acid receptor alpha
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Number of residues462
Molecular Weight50770.805
Theoretical pI7.95
GO Classification
Functions
    protein heterodimerization activity
receptor binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
retinoic acid receptor activity
transcription factor binding
protein domain specific binding
retinoic acid-responsive element binding
RNA polymerase II regulatory region sequence-specific DNA binding
zinc ion binding
enzyme binding
alpha-actinin binding
transcription coactivator activity
retinoic acid binding
protein kinase A binding
steroid hormone receptor activity
protein kinase B binding
chromatin DNA binding
Processes
    cellular response to estrogen stimulus
positive regulation of cell cycle
glandular epithelial cell development
chondroblast differentiation
negative regulation of translational initiation
ureteric bud development
negative regulation of transcription from RNA polymerase II promoter
positive regulation of interleukin-13 production
spermatogenesis
cellular response to retinoic acid
negative regulation of tumor necrosis factor production
cellular response to lipopolysaccharide
positive regulation of interleukin-5 production
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
growth plate cartilage development
positive regulation of T-helper 2 cell differentiation
Sertoli cell fate commitment
multicellular organism growth
negative regulation of cartilage development
germ cell development
negative regulation of interferon-gamma production
trachea cartilage development
negative regulation of apoptotic process
positive regulation of binding
positive regulation of interleukin-4 production
limb development
retinoic acid receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of granulocyte differentiation
apoptotic cell clearance
ventricular cardiac muscle cell differentiation
protein phosphorylation
signal transduction
neural tube closure
embryonic camera-type eye development
gene expression
face development
transcription initiation from RNA polymerase II promoter
positive regulation of cell proliferation
response to retinoic acid
outflow tract septum morphogenesis
Components
    nucleoplasm
neuronal cell body
cell surface
actin cytoskeleton
cytoplasm
dendrite
nuclear chromatin
nucleus
General FunctionZinc ion binding
Specific FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
Transmembrane Regions
GenBank Protein ID36157
UniProtKB IDP10276
UniProtKB Entry NameRARA_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016168|Retinoic acid receptor alpha (RARA)
ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCG
GTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCT
CTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCACC
ATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCT
CTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTAT
GGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTTCTTCCGCCGCAGCATCCAGAAGAACATG
GTGTACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGC
CAGTACTGCCGACTGCAGAAGTGCTTTGAAGTGGGCATGTCCAAGGAGTCTGTGAGAAAC
GACCGAAACAAGAAGAAGAAGGAGGTGCCCAAGCCCGAGTGCTCTGAGAGCTACACGCTG
ACGCCGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCT
GCCCTCTGCCAGCTGGGCAAATACACTACGAACAACAGCTCAGAACAACGTGTCTCTCTG
GACATTGACCTCTGGGACAAGTTCAGTGAACTCTCCACCAAGTGCATCATTAAGACTGTG
GAGTTCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTC
CTCAAGGCTGCCTGCCTGGACATCCTGATCCTGCGGATCTGCACGCGGTACACGCCCGAG
CAGGACACCATGACCTTCTCGGACGGGCTGACCCTGAACCGGACCCAGATGCACAACGCT
GGCTTCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAG
ATGGATGATGCGGAGACGGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGACCGCCAG
GACCTGGAGCAGCCGGACCGGGTGGACATGCTGCAGGAGCCGCTGCTGGAGGCGCTAAAG
GTCTACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAG
ATTACTGACCTGCGAAGCATCAGCGCCAAGGGGGCTGAGCGGGTGATCACGCTGAAGATG
GAGATCCCGGGCTCCATGCCGCCTCTCATCCAGGAAATGTTGGAGAACTCAGAGGGCCTG
GACACTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCG
CCAGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCTCCAACAGAAGCAGCCCGGCCACCCAC
TCCCCGTGA
GenBank Gene IDX06614
GeneCard IDNone
GenAtlas IDRARA
HGNC IDHGNC:9864
Chromosome Location17
Locus17q21
References
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