Thyroid hormone receptor alpha

NameThyroid hormone receptor alpha
Synonymsc-erbA-1 c-erbA-alpha EAR-7 EAR7 ERBA1 NR1A1 Nuclear receptor subfamily 1 group A member 1 THRA1 THRA2 V-erbA-related protein 7
Gene NameTHRA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001370|Thyroid hormone receptor alpha
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
Number of residues490
Molecular Weight54815.055
Theoretical pI6.85
GO Classification
Functions
    steroid receptor RNA activator RNA binding
TBP-class protein binding
thyroid hormone receptor activity
transcription factor binding
transcription regulatory region DNA binding
thyroid hormone binding
protein domain specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
sequence-specific DNA binding
zinc ion binding
chromatin DNA binding
steroid hormone receptor activity
intronic transcription regulatory region DNA binding
transcription factor activity, sequence-specific DNA binding
Processes
    positive regulation of transcription from RNA polymerase II promoter
female courtship behavior
response to drug
embryonic organ development
kidney development
intracellular receptor signaling pathway
positive regulation of female receptivity
response to nutrient levels
negative regulation of DNA-templated transcription, initiation
regulation of heart contraction
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
Type I pneumocyte differentiation
brain development
regulation of myeloid cell apoptotic process
cartilage condensation
positive regulation of myotube differentiation
adrenal gland development
regulation of thyroid hormone mediated signaling pathway
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cytoplasmic sequestering of transcription factor
liver development
negative regulation of sequence-specific DNA binding transcription factor activity
gene expression
erythrocyte differentiation
hormone-mediated signaling pathway
negative regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
thyroid gland development
ossification
response to cold
regulation of lipid catabolic process
learning or memory
digestive tract development
Components
    mitochondrion
cytosol
nucleoplasm
nucleus
General FunctionZinc ion binding
Specific FunctionIsoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Transmembrane Regions
GenBank Protein ID825639
UniProtKB IDP10827
UniProtKB Entry NameTHA_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016176|Thyroid hormone receptor alpha (THRA)
ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGG
TCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCA
GGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA
ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACA
ATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGAC
AAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG
GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAG
AACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCC
ACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC
CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCC
ATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAG
ATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC
GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCC
CTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATG
GCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT
GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAG
GCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAG
AGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT
CCGCACTTCTGGCCCAAGCTGCTGATGAAGGGTCCGCAGGTCCGGCAGCTTGAGCAGCAG
CTTGGTGAAGCGGGAAGTCTCCAAGGGCCGGTTCTTCAGCACCAGAGCCCGAAGAGCCCG
CAGCAGCGTCTCCTGGAGCTGCTCCACCGAAGCGGAATTCTCCATGCCCGAGCGGTCTGT
GGGGAAGACGACAGCAGTGAGGCGGACTCCCCGAGCTCCTCTGAGGAGGAACCGGAGGTC
TGCGAGGACCTGGCAGGCAATGCAGCCTCTCCCTGA
GenBank Gene IDX55074
GeneCard IDNone
GenAtlas IDTHRA
HGNC IDHGNC:11796
Chromosome Location17
Locus17q11.2
References
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