78 kDa glucose-regulated protein
| Name | 78 kDa glucose-regulated protein |
|---|---|
| Synonyms | BiP Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 GRP-78 GRP78 Heat shock 70 kDa protein 5 Immunoglobulin heavy chain-binding protein |
| Gene Name | HSPA5 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0019062|78 kDa glucose-regulated protein MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL |
| Number of residues | 654 |
| Molecular Weight | 72332.425 |
| Theoretical pI | 4.8 |
| GO Classification |
Functions
unfolded protein binding protein domain specific binding ubiquitin protein ligase binding ATP binding chaperone binding enzyme binding ribosome binding calcium ion binding misfolded protein binding ATPase activity glycoprotein binding Processes
ER-associated ubiquitin-dependent protein catabolic process cellular protein metabolic process cerebellum structural organization positive regulation of protein ubiquitination ER overload response cerebellar Purkinje cell layer development negative regulation of apoptotic process maintenance of protein localization in endoplasmic reticulum substantia nigra development ATF6-mediated unfolded protein response platelet degranulation regulation of ATF6-mediated unfolded protein response protein folding in endoplasmic reticulum regulation of IRE1-mediated unfolded protein response platelet activation toxin transport regulation of PERK-mediated unfolded protein response blood coagulation cellular response to glucose starvation regulation of protein folding in endoplasmic reticulum negative regulation of protein homodimerization activity negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response cellular response to antibiotic positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress PERK-mediated unfolded protein response IRE1-mediated unfolded protein response positive regulation of cell migration activation of signaling protein activity involved in unfolded protein response cellular response to interleukin-4 Components
plasma membrane endoplasmic reticulum membrane midbody integral component of endoplasmic reticulum membrane endoplasmic reticulum chaperone complex mitochondrion membrane smooth endoplasmic reticulum cell surface focal adhesion endoplasmic reticulum-Golgi intermediate compartment extracellular exosome nucleus myelin sheath endoplasmic reticulum endoplasmic reticulum lumen melanosome |
| General Function | Unfolded protein binding |
| Specific Function | Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. |
| Transmembrane Regions | |
| GenBank Protein ID | 386758 |
| UniProtKB ID | P11021 |
| UniProtKB Entry Name | GRP78_HUMAN |
| Cellular Location | Endoplasmic reticulum lumen |
| Gene sequence | >lcl|BSEQ0019063|78 kDa glucose-regulated protein (HSPA5) ATGAAGCTCTCCCTGGTGGCCGCGATGCTGCTGCTGCTCAGCGCGGCGCGGGCCGAGGAG GAGGACAAGAAGGAGGACGTGGGCACGGTGGTCGGCATCGACCTGGGGACCACCTACTCC TGCGTCGGCGTGTTCAAGAACGGCCGCGTGGAGATCATCGCCAACGATCAGGGCAACCGC ATCACGCCGTCCTATGTCGCCTTCACTCCTGAAGGGGAACGTCTGATTGGCGATGCCGCC AAGAACCAGCTCACCTCCAACCCCGAGAACACGGTCTTTGACGCCAAGCGGCTCATCGGC CGCACGTGGAATGACCCGTCTGTGCAGCAGGACATCAAGTTCTTGCCGTTCAAGGTGGTT GAAAAGAAAACTAAACCATACATTCAAGTTGATATTGGAGGTGGGCAAACAAAGACATTT GCTCCTGAAGAAATTTCTGCCATGGTTCTCACTAAAATGAAAGAAACCGCTGAGGCTTAT TTGGGAAAGAAGGTTACCCATGCAGTTGTTACTGTACCAGCCTATTTTAATGATGCCCAA CGCCAAGCAACCAAAGACGCTGGAACTATTGCTGGCCTAAATGTTATGAGGATCATCAAC GAGCCTACGGCAGCTGCTATTGCTTATGGCCTGGATAAGAGGGAGGGGGAGAAGAACATC CTGGTGTTTGACCTGGGTGGCGGAACCTTCGATGTGTCTCTTCTCACCATTGACAATGGT GTCTTCGAAGTTGTGGCCACTAATGGAGATACTCATCTGGGTGGAGAAGACTTTGACCAG CGTGTCATGGAACACTTCATCAAACTGTACAAAAAGAAGACGGGCAAAGATGTCAGGAAA GACAATAGAGCTGTGCAGAAACTCCGGCGCGAGGTAGAAAAGGCCAAACGGGCCCTGTCT TCTCAGCATCAAGCAAGAATTGAAATTGAGTCCTTCTATGAAGGAGAAGACTTTTCTGAG ACCCTGACTCGGGCCAAATTTGAAGAGCTCAACATGGATCTGTTCCGGTCTACTATGAAG CCCGTCCAGAAAGTGTTGGAAGATTCTGATTTGAAGAAGTCTGATATTGATGAAATTGTT CTTGTTGGTGGCTCGACTCGAATTCCAAAGATTCAGCAACTGGTTAAAGAGTTCTTCAAT GGCAAGGAACCATCCCGTGGCATAAACCCAGATGAAGCTGTAGCGTATGGTGCTGCTGTC CAGGCTGGTGTGCTCTCTGGTGATCAAGATACAGGTGACCTGGTACTGCTTGATGTATGT CCCCTTACACTTGGTATTGAAACTGTGGGAGGTGTCATGACCAAACTGATTCCAAGGAAC ACAGTGGTGCCTACCAAGAAGTCTCAGATCTTTTCTACAGCTTCTGATAATCAACCAACT GTTACAATCAAGGTCTATGAAGGTGAAAGACCCCTGACAAAAGACAATCATCTTCTGGGT ACATTTGATCTGACTGGAATTCCTCCTGCTCCTCGTGGGGTCCCACAGATTGAAGTCACC TTTGAGATAGATGTGAATGGTATTCTTCGAGTGACAGCTGAAGACAAGGGTACAGGGAAC AAAAATAAGATCACAATCACCAATGACCAGAATCGCCTGACACCTGAAGAAATCGAAAGG ATGGTTAATGATGCTGAGAAGTTTGCTGAGGAAGACAAAAAGCTCAAGGAGCGCATTGAT ACTAGAAATGAGTTGGAAAGCTATGCCTATTCTCTAAAGAATCAGATTGGAGATAAAGAA AAGCTGGGAGGTAAACTTTCCTCTGAAGATAAGGAGACCATGGAAAAAGCTGTAGAAGAA AAGATTGAATGGCTGGAAAGCCACCAAGATGCTGACATTGAAGACTTCAAAGCTAAGAAG AAGGAACTGGAAGAAATTGTTCAACCAATTATCAGCAAACTCTATGGAAGTGCAGGCCCT CCCCCAACTGGTGAAGAGGATACAGCAGAAAAAGATGAGTTGTAG |
| GenBank Gene ID | M19645 |
| GeneCard ID | None |
| GenAtlas ID | HSPA5 |
| HGNC ID | HGNC:5238 |
| Chromosome Location | 9 |
| Locus | 9q33-q34.1 |
| References |
|
Related FRC
| FRCD ID | Name | Exact Mass | Structure |
|---|---|---|---|
Aspirin |
180.159 |