Solute carrier family 2, facilitated glucose transporter member 3


NameSolute carrier family 2, facilitated glucose transporter member 3
SynonymsGlucose transporter type 3, brain GLUT-3 GLUT3
Gene NameSLC2A3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017515|Solute carrier family 2, facilitated glucose transporter member 3
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLT
SLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEML
ILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGS
EELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQ
EMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG
VQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYN
GMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLF
PSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGV
MEMNSIEPAKETTTNV
Number of residues496
Molecular Weight53923.785
Theoretical pINone
GO Classification
Functions
    glucose transmembrane transporter activity
    glucose binding
Processes
    vitamin metabolic process
    water-soluble vitamin metabolic process
    L-ascorbic acid metabolic process
    glucose transport
    hexose transport
    small molecule metabolic process
    glucose transmembrane transport
    carbohydrate metabolic process
    transmembrane transport
Components
    plasma membrane
    integral component of membrane
    extracellular exosome
    integral component of plasma membrane
General FunctionGlucose transmembrane transporter activity
Specific FunctionFacilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).
Transmembrane Regions11-32 65-85 91-111 119-142 154-174 184-204 270-290 305-325 332-352 364-389 400-420 430-450
GenBank Protein ID
UniProtKB IDP11169
UniProtKB Entry NameGTR3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017516|Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)
ATGGGGACACAGAAGGTCACCCCAGCTCTGATATTTGCCATCACAGTTGCTACAATCGGC
TCTTTCCAATTTGGCTACAACACTGGGGTCATCAATGCTCCTGAGAAGATCATAAAGGAA
TTTATCAATAAAACTTTGACGGACAAGGGAAATGCCCCACCCTCTGAGGTGCTGCTCACG
TCTCTCTGGTCCTTGTCTGTGGCCATATTTTCCGTCGGGGGTATGATCGGCTCCTTTTCC
GTCGGACTCTTCGTCAACCGCTTTGGCAGGCGCAATTCAATGCTGATTGTCAACCTGTTG
GCTGTCACTGGTGGCTGCTTTATGGGACTGTGTAAAGTAGCTAAGTCGGTTGAAATGCTG
ATCCTGGGTCGCTTGGTTATTGGCCTCTTCTGCGGACTCTGCACAGGTTTTGTGCCCATG
TACATTGGAGAGATCTCGCCTACTGCCCTGCGGGGTGCCTTTGGCACTCTCAACCAGCTG
GGCATCGTTGTTGGAATTCTGGTGGCCCAGATCTTTGGTCTGGAATTCATCCTTGGGTCT
GAAGAGCTATGGCCGCTGCTACTGGGTTTTACCATCCTTCCTGCTATCCTACAAAGTGCA
GCCCTTCCATTTTGCCCTGAAAGTCCCAGATTTTTGCTCATTAACAGAAAAGAAGAGGAG
AATGCTAAGCAGATCCTCCAGCGGTTGTGGGGCACCCAGGATGTATCCCAAGACATCCAG
GAGATGAAAGATGAGAGTGCAAGGATGTCACAAGAAAAGCAAGTCACCGTGCTAGAGCTC
TTTAGAGTGTCCAGCTACCGACAGCCCATCATCATTTCCATTGTGCTCCAGCTCTCTCAG
CAGCTCTCTGGGATCAATGCTGTGTTCTATTACTCAACAGGAATCTTCAAGGATGCAGGT
GTTCAAGAGCCCATCTATGCCACCATCGGCGCGGGTGTGGTTAATACTATCTTCACTGTA
GTTTCTCTATTTCTGGTGGAAAGGGCAGGAAGAAGGACTCTGCATATGATAGGCCTTGGA
GGGATGGCTTTTTGTTCCACGCTCATGACTGTTTCTTTGTTATTAAAGGATAACTATAAT
GGGATGAGCTTTGTCTGTATTGGGGCTATCTTGGTCTTTGTAGCCTTCTTTGAAATTGGA
CCAGGCCCCATTCCCTGGTTTATTGTGGCCGAACTCTTCAGCCAGGGCCCCCGCCCAGCT
GCGATGGCAGTGGCCGGCTGCTCCAACTGGACCTCCAACTTCCTAGTCGGATTGCTCTTC
CCCTCCGCTGCTCACTATTTAGGAGCCTACGTTTTTATTATCTTCACCGGCTTCCTCATT
ACCTTCTTGGCTTTTACCTTCTTCAAAGTCCCTGAGACCCGTGGCAGGACTTTTGAGGAT
ATCACACGGGCCTTTGAAGGGCAGGCACACGGTGCAGATAGATCTGGAAAGGACGGCGTC
ATGGAGATGAACAGCATCGAGCCTGCTAAGGAGACCACCACCAATGTCTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:11007
Chromosome Location12
LocusNone
References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7.[15489334 ]
  2. Kayano T, Fukumoto H, Eddy RL, Fan YS, Byers MG, Shows TB, Bell GI: Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem. 1988 Oct 25;263(30):15245-8.[3170580 ]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21.[14702039 ]
  4. Seatter MJ, De la Rue SA, Porter LM, Gould GW: QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site. Biochemistry. 1998 Feb 3;37(5):1322-6.[9477959 ]
  5. Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, Ren W, Hirata K, Yamamoto M, Fan S, Yan N: Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015 Oct 15;526(7573):391-6. doi: 10.1038/nature14655. Epub 2015 Jul 15.[26176916 ]

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