Cytochrome P450 2C9


NameCytochrome P450 2C9
Synonyms(R)-limonene 6-monooxygenase (S)-limonene 6-monooxygenase (S)-limonene 7-monooxygenase 1.14.13.- Cholesterol 25-hydroxylase CYP2C10 CYPIIC9 Cytochrome P-450MP Cytochrome P450 MP-4 Cytochrome P450 MP-8 Cytochrome P450 PB-1 S-mephenytoin 4-hydroxylase
Gene NameCYP2C9
OrganismHuman
Amino acid sequence
>lcl|BSEQ0005471|Cytochrome P450 2C9
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
Number of residues490
Molecular Weight55627.365
Theoretical pI7.99
GO Classification
Functions
    steroid hydroxylase activity
    (R)-limonene 6-monooxygenase activity
    oxygen binding
    (S)-limonene 6-monooxygenase activity
    aromatase activity
    (S)-limonene 7-monooxygenase activity
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    caffeine oxidase activity
    drug binding
    oxidoreductase activity
    iron ion binding
    heme binding
    arachidonic acid epoxygenase activity
    monooxygenase activity
Processes
    epoxygenase P450 pathway
    exogenous drug catabolic process
    monocarboxylic acid metabolic process
    cellular amide metabolic process
    small molecule metabolic process
    urea metabolic process
    drug catabolic process
    oxidation-reduction process
    monoterpenoid metabolic process
    steroid metabolic process
    omega-hydroxylase P450 pathway
    xenobiotic metabolic process
    oxidative demethylation
    arachidonic acid metabolic process
    drug metabolic process
Components
    cytoplasm
    endoplasmic reticulum membrane
    intracellular membrane-bounded organelle
General FunctionSteroid hydroxylase activity
Specific FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP11712
UniProtKB Entry NameCP2C9_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0016893|Cytochrome P450 2C9 (CYP2C9)
ATGGATTCTCTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCACTCTGG
AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA
AATATCCTACAGATAGGTATTAAGGACATCAGCAAATCCTTAACCAATCTCTCAAAGGTC
TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGAAACCCATAGTGGTGCTGCATGGATAT
GAAGCAGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCATTTTC
CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATTGTTTTCAGCAATGGAAAGAAATGG
AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC
ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG
GCCTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC
ATTATTTTCCATAAACGTTTTGATTATAAAGATCAGCAATTTCTTAACTTAATGGAAAAG
TTGAATGAAAACATCAAGATTTTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCT
CCTATCATTGATTACTTCCCGGGAACTCACAACAAATTACTTAAAAACGTTGCTTTTATG
AAAAGTTATATTTTGGAAAAAGTAAAAGAACACCAAGAATCAATGGACATGAACAACCCT
CAGGACTTTATTGATTGCTTCCTGATGAAAATGGAGAAGGAAAAGCACAACCAACCATCT
GAATTTACTATTGAAAGCTTGGAAAACACTGCAGTTGACTTGTTTGGAGCTGGGACAGAG
ACGACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA
GCTAAAGTCCAGGAAGAGATTGAACGTGTGATTGGCAGAAACCGGAGCCCCTGCATGCAA
GACAGGAGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATTGAC
CTTCTCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACATTAAATTCAGAAACTATCTC
ATTCCCAAGGGCACAACCATATTAATTTCCCTGACTTCTGTGCTACATGACAACAAAGAA
TTTCCCAACCCAGAGATGTTTGACCCTCATCACTTTCTGGATGAAGGTGGCAATTTTAAG
AAAAGTAAATACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAAGCCCTG
GCCGGCATGGAGCTGTTTTTATTCCTGACCTCCATTTTACAGAACTTTAACCTGAAATCT
CTGGTTGACCCAAAGAACCTTGACACCACTCCAGTTGTCAATGGATTTGCCTCTGTGCCG
CCCTTCTACCAGCTGTGCTTCATTCCTGTCTGA
GenBank Gene IDAY341248
GeneCard IDNone
GenAtlas IDCYP2C9
HGNC IDHGNC:2623
Chromosome Location10
Locus10q24
References
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Related FRC


FRCD ID Name Exact Mass Structure



Fenpropathrin




349.43



Warfarin




308.333



Clotrimazole




344.842



Anidulafungin




1140.254



Ibuprofen




206.285



Omeprazole




345.417



Ochratoxin A




403.815



Aflatoxin M2




330.292



Bensulide




397.503



Bifenazate




300.358



Boscalid




343.207



Cinmethylin




274.404



Clofentezine




303.146



Cloprop




200.618



Diclosulam




406.213



Difenoconazole




406.263



Etoxazole




359.417



Fenhexamid




302.195



Fenitrothion




277.24



Fluazinam




465.089



Flusilazole




315.399



Folpet




296.546



Fosthiazate




283.341



Enilconazole




297.179



Lactofen




461.774



Malathion




330.35



Myclobutanil




288.779



Phosalone




367.799



Prochloraz




376.662



Propiconazole




342.22



Pyraclostrobin




387.82



Pyriproxyfen




321.376



Spiroxamine




297.483



Sulfentrazone




387.183



Tebufenozide




352.478



Tebuthiuron




228.314



Tetraconazole




372.145



Thiabendazole




201.247



Triasulfuron




401.822



Triclosan




289.536



1-Hydroxypyrene




220.271



Butylparaben




194.23



Progesterone




314.469



Atrazine




215.685



Butylate




217.371



Carboxin




235.301



Chlorethoxyfos




335.985



Clomazone




239.699



Coumaphos




362.761



Cyazofamid




324.783



Cyproconazole




291.779



Famoxadone




374.396



Fenarimol




331.196



Forchlorfenuron




247.682



Isazofos




313.737



Novaluron




492.706



Triadimefon




293.751



Triadimenol




295.767



Triflumizole




345.75



Trifluralin




335.283



Triticonazole




317.817



Ethinyl Estradiol




296.41



Celecoxib




381.373



Hexylresorcinol




194.274



Methoxychlor




345.644



Isopimpinellin




246.21



Heratomin




270.284



Asulam




230.238



Bendiocarb




223.228



Sertraline




306.2



Dicumarol




336.299



Clothianidin




249.673



Fenamidone




311.403



Iprodione




330.165



Methidathion




302.318



Metribuzin




214.287



(E)-Monocrotophos




223.16



Napropamide




271.36



Propoxycarbazone-sodium




420.372



Clopyralid




191.995



Hexaconazole




314.21



Prallethrin




300.398



Profenofos




373.626



Rimsulfuron




431.438



Thiram




240.416



Benzidine




184.242



Disulfoton




274.392



Guthion




317.318



Dicofol




370.475



Parathion




291.258



Dimethoate




229.3



(±)-Naled




380.778



Mercuric chloride




271.492



Bisphenol A




228.291



Ethanol




46.07



Rotenone




394.423



Sphondin




216.19



Angelicin




186.16



Isobergapten




216.19



Pimpinellin




246.21



Psoralen




186.16



Isoimperatorin




270.28



Bergamottin




338.403



Methoxsalen




216.19



Imperatorin




270.28



Phellopterin




300.31



Propoxur




209.245



Thiobencarb




257.776



Allethrin




302.414



Resmethrin




338.447



Cypermethrin




416.298



Butachlor




311.85