Proto-oncogene tyrosine-protein kinase Src

NameProto-oncogene tyrosine-protein kinase Src
Synonyms2.7.10.2 p60-Src pp60c-src Proto-oncogene c-Src SRC1
Gene NameSRC
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037090|Proto-oncogene tyrosine-protein kinase Src
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Number of residues536
Molecular Weight59834.295
Theoretical pI7.47
GO Classification
Functions
    phosphoprotein binding
enzyme binding
integrin binding
heme binding
receptor binding
SH3/SH2 adaptor activity
protein tyrosine kinase activity
ATP binding
kinase activity
ephrin receptor binding
non-membrane spanning protein tyrosine kinase activity
ion channel binding
SH2 domain binding
protein kinase activity
hormone receptor binding
growth factor receptor binding
scaffold protein binding
kinase binding
Processes
    negative regulation of intrinsic apoptotic signaling pathway
blood coagulation
cellular response to reactive oxygen species
neurotrophin TRK receptor signaling pathway
regulation of vascular permeability
cellular response to progesterone stimulus
positive regulation of ERK1 and ERK2 cascade
innate immune response
uterus development
oogenesis
Ras protein signal transduction
positive regulation of protein serine/threonine kinase activity
positive regulation of integrin activation
protein autophosphorylation
peptidyl-tyrosine autophosphorylation
viral process
negative regulation of protein homooligomerization
stimulatory C-type lectin receptor signaling pathway
regulation of bone resorption
regulation of caveolin-mediated endocytosis
transforming growth factor beta receptor signaling pathway
branching involved in mammary gland duct morphogenesis
peptidyl-tyrosine phosphorylation
positive regulation of protein kinase B signaling
regulation of cell-cell adhesion
vascular endothelial growth factor receptor signaling pathway
bone resorption
regulation of cell projection assembly
negative regulation of extrinsic apoptotic signaling pathway
osteoclast development
positive regulation of peptidyl-tyrosine phosphorylation
response to interleukin-1
membrane organization
cellular response to fluid shear stress
signal complex assembly
negative regulation of anoikis
regulation of cell proliferation
negative regulation of focal adhesion assembly
regulation of cell cycle
negative regulation of telomerase activity
integrin-mediated signaling pathway
stress fiber assembly
T cell costimulation
signal transduction
positive regulation of podosome assembly
leukocyte migration
progesterone receptor signaling pathway
regulation of epithelial cell migration
intracellular signal transduction
regulation of early endosome to late endosome transport
regulation of podosome assembly
positive regulation of canonical Wnt signaling pathway
substrate adhesion-dependent cell spreading
small GTPase mediated signal transduction
positive regulation of lamellipodium morphogenesis
positive regulation of epithelial cell migration
axon guidance
forebrain development
regulation of intracellular estrogen receptor signaling pathway
fibroblast growth factor receptor signaling pathway
negative regulation of mitochondrial depolarization
cell differentiation
negative regulation of apoptotic process
cell cycle
negative regulation of telomere maintenance via telomerase
epidermal growth factor receptor signaling pathway
ephrin receptor signaling pathway
cell adhesion
regulation of protein binding
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to peptide hormone stimulus
platelet activation
angiotensin-activated signaling pathway involved in heart process
cellular response to platelet-derived growth factor stimulus
Fc-gamma receptor signaling pathway involved in phagocytosis
protein destabilization
Components
    actin filament
nucleus
mitochondrial inner membrane
cytosol
extracellular exosome
cytoplasm
plasma membrane
extrinsic component of cytoplasmic side of plasma membrane
mitochondrion
perinuclear region of cytoplasm
lysosome
ruffle membrane
caveola
late endosome
General FunctionSh3/sh2 adaptor activity
Specific FunctionNon-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors. Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of ADRBK1, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-128'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Required for podosome formation (By similarity).
Transmembrane Regions
GenBank Protein ID10635153
UniProtKB IDP12931
UniProtKB Entry NameSRC_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021959|Proto-oncogene tyrosine-protein kinase Src (SRC)
ATGGGTAGCAACAAGAGCAAGCCCAAGGATGCCAGCCAGCGGCGCCGCAGCCTGGAGCCC
GCCGAGAACGTGCACGGCGCTGGCGGGGGCGCTTTCCCCGCCTCGCAGACCCCCAGCAAG
CCAGCCTCGGCCGACGGCCACCGCGGCCCCAGCGCGGCCTTCGCCCCCGCGGCCGCCGAG
CCCAAGCTGTTCGGAGGCTTCAACTCCTCGGACACCGTCACCTCCCCGCAGAGGGCGGGC
CCGCTGGCCGGTGGAGTGACCACCTTTGTGGCCCTCTATGACTATGAGTCTAGGACGGAG
ACAGACCTGTCCTTCAAGAAAGGCGAGCGGCTCCAGATTGTCAACAACACAGAGGGAGAC
TGGTGGCTGGCCCACTCGCTCAGCACAGGACAGACAGGCTACATCCCCAGCAACTACGTG
GCGCCCTCCGACTCCATCCAGGCTGAGGAGTGGTATTTTGGCAAGATCACCAGACGGGAG
TCAGAGCGGTTACTGCTCAATGCAGAGAACCCGAGAGGGACCTTCCTCGTGCGAGAAAGT
GAGACCACGAAAGGTGCCTACTGCCTCTCAGTGTCTGACTTCGACAACGCCAAGGGCCTC
AACGTGAAGCACTACAAGATCCGCAAGCTGGACAGCGGCGGCTTCTACATCACCTCCCGC
ACCCAGTTCAACAGCCTGCAGCAGCTGGTGGCCTACTACTCCAAACACGCCGATGGCCTG
TGCCACCGCCTCACCACCGTGTGCCCCACGTCCAAGCCGCAGACTCAGGGCCTGGCCAAG
GATGCCTGGGAGATCCCTCGGGAGTCGCTGCGGCTGGAGGTCAAGCTGGGCCAGGGCTGC
TTTGGCGAGGTGTGGATGGGGACCTGGAACGGTACCACCAGGGTGGCCATCAAAACCCTG
AAGCCTGGCACGATGTCTCCAGAGGCCTTCCTGCAGGAGGCCCAGGTCATGAAGAAGCTG
AGGCATGAGAAGCTGGTGCAGTTGTATGCTGTGGTTTCAGAGGAGCCCATTTACATCGTC
ACGGAGTACATGAGCAAGGGGAGTTTGCTGGACTTTCTCAAGGGGGAGACAGGCAAGTAC
CTGCGGCTGCCTCAGCTGGTGGACATGGCTGCTCAGATCGCCTCAGGCATGGCGTACGTG
GAGCGGATGAACTACGTCCACCGGGACCTTCGTGCAGCCAACATCCTGGTGGGAGAGAAC
CTGGTGTGCAAAGTGGCCGACTTTGGGCTGGCTCGGCTCATTGAAGACAATGAGTACACG
GCGCGGCAAGGTGCCAAATTCCCCATCAAGTGGACGGCTCCAGAAGCTGCCCTCTATGGC
CGCTTCACCATCAAGTCGGACGTGTGGTCCTTCGGGATCCTGCTGACTGAGCTCACCACA
AAGGGACGGGTGCCCTACCCTGGGATGGTGAACCGCGAGGTGCTGGACCAGGTGGAGCGG
GGCTACCGGATGCCCTGCCCGCCGGAGTGTCCCGAGTCCCTGCACGACCTCATGTGCCAG
TGCTGGCGGAAGGAGCCTGAGGAGCGGCCCACCTTCGAGTACCTGCAGGCCTTCCTGGAG
GACTACTTCACGTCCACCGAGCCCCAGTACCAGCCCGGGGAGAACCTCTAG
GenBank Gene IDAL133293
GeneCard IDNone
GenAtlas IDSRC
HGNC IDHGNC:11283
Chromosome Location20
Locus20q12-q13
References
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