Retinoic acid receptor gamma
Name | Retinoic acid receptor gamma |
---|---|
Synonyms | NR1B3 Nuclear receptor subfamily 1 group B member 3 RAR-gamma |
Gene Name | RARG |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0000287|Retinoic acid receptor gamma MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA |
Number of residues | 454 |
Molecular Weight | 50341.405 |
Theoretical pI | 7.52 |
GO Classification |
Functions
DNA binding retinoic acid receptor activity retinoid X receptor binding transcription factor activity, sequence-specific DNA binding zinc ion binding steroid hormone receptor activity RNA polymerase II regulatory region sequence-specific DNA binding Processes
anterior/posterior pattern specification negative regulation of apoptotic process retinoic acid receptor signaling pathway embryonic camera-type eye development negative regulation of cell proliferation embryonic eye morphogenesis glandular epithelial cell development positive regulation of transcription from RNA polymerase II promoter face development trachea cartilage development positive regulation of cell proliferation gene expression growth plate cartilage chondrocyte growth negative regulation of transcription from RNA polymerase II promoter regulation of myeloid cell differentiation transcription initiation from RNA polymerase II promoter Harderian gland development regulation of myelination response to retinoic acid prostate gland epithelium morphogenesis neural tube closure canonical Wnt signaling pathway regulation of cell size negative regulation of chondrocyte differentiation positive regulation of apoptotic process positive regulation of programmed cell death cellular response to retinoic acid embryonic hindlimb morphogenesis retinal pigment epithelium development multicellular organism growth Components
nucleus integral component of membrane transcription factor complex nucleoplasm nuclear chromatin |
General Function | Zinc ion binding |
Specific Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). |
Transmembrane Regions | |
GenBank Protein ID | 306887 |
UniProtKB ID | P13631 |
UniProtKB Entry Name | RARG_HUMAN |
Cellular Location | Nucleus |
Gene sequence | >lcl|BSEQ0020450|Retinoic acid receptor gamma (RARG) ATGGCCACCAATAAGGAGCGACTCTTTGCGGCTGGTGCCCTGGGGCCTGGATCTGGCTAC CCAGGGGCAGGTTTCCCCTTCGCCTTCCCAGGGGCACTCAGGGGGTCTCCGCCTTTCGAG ATGCTGAGCCCTAGCTTCCGGGGCCTGGGCCAGCCTGACCTCCCCAAGGAGATGGCCTCT CTGTCGGTGGAGACACAGAGCACCAGCTCAGAGGAGATGGTGCCCAGCTCGCCCTCGCCC CCTCCGCCTCCTCGGGTCTACAAGCCATGCTTCGTGTGCAATGACAAGTCCTCTGGCTAC CACTATGGGGTCAGCTCTTGTGAAGGCTGCAAGGGCTTCTTTCGCCGAAGCATCCAGAAG AACATGGTGTACACGTGTCACCGCGACAAAAACTGTATCATCAACAAGGTGACCAGGAAT CGCTGCCAGTACTGCCGGCTACAGAAGTGCTTCGAAGTGGGCATGTCCAAGGAAGCTGTG CGAAATGACCGGAACAAGAAGAAGAAAGAGGTGAAGGAAGAAGGGTCACCTGACAGCTAT GAGCTGAGCCCTCAGTTAGAAGAGCTCATCACCAAGGTCAGCAAAGCCCATCAGGAGACT TTCCCCTCGCTCTGCCAGCTGGGCAAGTATACCACGAACTCCAGTGCAGACCACCGCGTG CAGCTGGATCTGGGGCTGTGGGACAAGTTCAGTGAGCTGGCTACCAAGTGCATCATCAAG ATCGTGGAGTTTGCCAAGCGGTTGCCTGGCTTTACAGGGCTCAGCATTGCTGACCAGATC ACTCTGCTCAAAGCTGCCTGCCTAGATATCCTGATGCTGCGTATCTGCACAAGGTACACC CCAGAGCAGGACACCATGACCTTCTCCGACGGGCTGACCCTGAACCGGACCCAGATGCAC AATGCCGGCTTCGGGCCCCTCACAGACCTTGTCTTTGCCTTTGCTGGGCAGCTCCTGCCC CTGGAGATGGATGACACCGAGACAGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGAC CGCATGGACCTGGAGGAGCCCGAAAAAGTGGACAAGCTGCAGGAGCCACTGCTGGAAGCC CTGAGGCTGTACGCCCGGCGCCGGCGGCCCAGCCAGCCCTACATGTTCCCAAGGATGCTA ATGAAAATCACCGACCTCCGGGGCATCAGCACTAAGGGAGCTGAAAGGGCCATTACTCTG AAGATGGAGATTCCAGGCCCGATGCCTCCCTTAATCCGAGAGATGCTGGAGAACCCTGAA ATGTTTGAGGATGACTCCTCGCAGCCTGGTCCCCACCCCAATGCCTCTAGCGAGGATGAG GTTCCTGGGGGCCAGGGCAAAGGGGGCCTGAAGTCCCCAGCCTGA |
GenBank Gene ID | M24857 |
GeneCard ID | None |
GenAtlas ID | RARG |
HGNC ID | HGNC:9866 |
Chromosome Location | 12 |
Locus | 12q13 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Tetrabutyltin |
347.174 |
||
Triphenyltin |
350.028 |
||
Chlordane |
409.758 |
||
Hydroxytriphenylstannane |
367.035 |
||
Azocyclotin |
436.231 |