Tissue factor
Name | Tissue factor |
---|---|
Synonyms | Coagulation factor III TF Thromboplastin |
Gene Name | F3 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0002343|Tissue factor METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS |
Number of residues | 295 |
Molecular Weight | 33067.3 |
Theoretical pI | 7.09 |
GO Classification |
Functions
phospholipid binding protease binding cytokine receptor activity Processes
response to fluid shear stress positive regulation of protein kinase B signaling response to mechanical stimulus positive regulation of positive chemotaxis response to temperature stimulus positive regulation of angiogenesis positive regulation of platelet-derived growth factor receptor signaling pathway aging activation of blood coagulation via clotting cascade positive regulation of cell migration cellular response to hydrogen peroxide activation of plasma proteins involved in acute inflammatory response response to estradiol positive regulation of endothelial cell proliferation response to lipopolysaccharide activation of cysteine-type endopeptidase activity involved in apoptotic process response to low-density lipoprotein particle blood coagulation cytokine-mediated signaling pathway positive regulation of smooth muscle cell migration blood coagulation, extrinsic pathway Components
extracellular space cell surface integral component of membrane extracellular exosome cytoplasm extracellular matrix intrinsic component of external side of plasma membrane plasma membrane |
General Function | Protease binding |
Specific Function | Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. |
Transmembrane Regions | 252-274 |
GenBank Protein ID | 339504 |
UniProtKB ID | P13726 |
UniProtKB Entry Name | TF_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0021656|Tissue factor (F3) ATGGAGACCCCTGCCTGGCCCCGGGTCCCGCGCCCCGAGACCGCCGTCGCTCGGACGCTC CTGCTCGGCTGGGTCTTCGCCCAGGTGGCCGGCGCTTCAGGCACTACAAATACTGTGGCA GCATATAATTTAACTTGGAAATCAACTAATTTCAAGACAATTTTGGAGTGGGAACCCAAA CCCGTCAATCAAGTCTACACTGTTCAAATAAGCACTAAGTCAGGAGATTGGAAAAGCAAA TGCTTTTACACAACAGACACAGAGTGTGACCTCACCGACGAGATTGTGAAGGATGTGAAG CAGACGTACTTGGCACGGGTCTTCTCCTACCCGGCAGGGAATGTGGAGAGCACCGGTTCT GCTGGGGAGCCTCTGTATGAGAACTCCCCAGAGTTCACACCTTACCTGGAGACAAACCTC GGACAGCCAACAATTCAGAGTTTTGAACAGGTGGGAACAAAAGTGAATGTGACCGTAGAA GATGAACGGACTTTAGTCAGAAGGAACAACACTTTCCTAAGCCTCCGGGATGTTTTTGGC AAGGACTTAATTTATACACTTTATTATTGGAAATCTTCAAGTTCAGGAAAGAAATATTCT ACATCATTGGAGCTGTGGTATTTGTGGTCATCATCCTTGTCATCATCCTGGCTATATCTC TACACAAGTGTAGAAAGGCAGGAGTGGGGCAGAGCTGGAAGGAGAACTCCCCACTGA |
GenBank Gene ID | M16553 |
GeneCard ID | None |
GenAtlas ID | F3 |
HGNC ID | HGNC:3541 |
Chromosome Location | 1 |
Locus | 1p22-p21 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Guthion |
317.318 |
||
Dicofol |
370.475 |
||
Tebufenpyrad |
333.86 |
||
Chlorothalonil |
265.902 |
||
Fenamidone |
311.403 |