G2/mitotic-specific cyclin-B1


NameG2/mitotic-specific cyclin-B1
SynonymsCCNB
Gene NameCCNB1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009795|G2/mitotic-specific cyclin-B1
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM
PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI
LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ
LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP
KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP
LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE
WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS
ALVQDLAKAVAKV
Number of residues433
Molecular Weight48337.06
Theoretical pINone
GO Classification
Functions
    patched binding
    protein kinase binding
    histone kinase activity
Processes
    response to drug
    positive regulation of fibroblast proliferation
    response to mechanical stimulus
    ventricular cardiac muscle cell development
    cellular response to organic cyclic compound
    regulation of cell cycle
    mitotic metaphase plate congression
    positive regulation of mitotic cell cycle
    digestive tract development
    cell division
    positive regulation of attachment of spindle microtubules to kinetochore
    G1/S transition of mitotic cell cycle
    positive regulation of cardiac muscle cell proliferation
    protein complex assembly
    negative regulation of gene expression
    oocyte maturation
    in utero embryonic development
    tissue regeneration
    mitotic nuclear envelope disassembly
    cellular response to iron(III) ion
    spermatogenesis
    negative regulation of protein phosphorylation
    histone H3-S10 phosphorylation involved in chromosome condensation
    regulation of mitotic cell cycle spindle assembly checkpoint
    mitotic spindle stabilization
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
    cellular response to fatty acid
    G2/M transition of mitotic cell cycle
    positive regulation of mRNA 3'-end processing
    positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
    positive regulation of histone phosphorylation
    mitotic cell cycle
    regulation of chromosome condensation
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
    cellular response to hypoxia
    response to DDT
Components
    centrosome
    condensed nuclear chromosome outer kinetochore
    cytosol
    nucleoplasm
    spindle pole
    cytoplasm
    membrane
    nucleus
General FunctionProtein kinase binding
Specific FunctionEssential for the control of the cell cycle at the G2/M (mitosis) transition.
Transmembrane Regions
GenBank Protein ID
UniProtKB IDP14635
UniProtKB Entry NameCCNB1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013916|G2/mitotic-specific cyclin-B1 (CCNB1)
ATGGCGCTCCGAGTCACCAGGAACTCGAAAATTAATGCTGAAAATAAGGCGAAGATCAAC
ATGGCAGGCGCAAAGCGCGTTCCTACGGCCCCTGCTGCAACCTCCAAGCCCGGACTGAGG
CCAAGAACAGCTCTTGGGGACATTGGTAACAAAGTCAGTGAACAACTGCAGGCCAAAATG
CCTATGAAGAAGGAAGCAAAACCTTCAGCTACTGGAAAAGTCATTGATAAAAAACTACCA
AAACCTCTTGAAAAGGTACCTATGCTGGTGCCAGTGCCAGTGTCTGAGCCAGTGCCAGAG
CCAGAACCTGAGCCAGAACCTGAGCCTGTTAAAGAAGAAAAACTTTCGCCTGAGCCTATT
TTGGTTGATACTGCCTCTCCAAGCCCAATGGAAACATCTGGATGTGCCCCTGCAGAAGAA
GACCTGTGTCAGGCTTTCTCTGATGTAATTCTTGCAGTAAATGATGTGGATGCAGAAGAT
GGAGCTGATCCAAACCTTTGTAGTGAATATGTGAAAGATATTTATGCTTATCTGAGACAA
CTTGAGGAAGAGCAAGCAGTCAGACCAAAATACCTACTGGGTCGGGAAGTCACTGGAAAC
ATGAGAGCCATCCTAATTGACTGGCTAGTACAGGTTCAAATGAAATTCAGGTTGTTGCAG
GAGACCATGTACATGACTGTCTCCATTATTGATCGGTTCATGCAGAATAATTGTGTGCCC
AAGAAGATGCTGCAGCTGGTTGGTGTCACTGCCATGTTTATTGCAAGCAAATATGAAGAA
ATGTACCCTCCAGAAATTGGTGACTTTGCTTTTGTGACTGACAACACTTATACTAAGCAC
CAAATCAGACAGATGGAAATGAAGATTCTAAGAGCTTTAAACTTTGGTCTGGGTCGGCCT
CTACCTTTGCACTTCCTTCGGAGAGCATCTAAGATTGGAGAGGTTGATGTCGAGCAACAT
ACTTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATGACATGGTGCACTTTCCT
CCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAAAATTCTGGATAATGGTGAA
TGGACACCAACTCTACAACATTACCTGTCATATACTGAAGAATCTCTTCTTCCAGTTATG
CAGCACCTGGCTAAGAATGTAGTCATGGTAAATCAAGGACTTACAAAGCACATGACTGTC
AAGAACAAGTATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGAATTCT
GCACTAGTTCAAGATTTAGCCAAGGCTGTGGCAAAGGTGTAA
GenBank Gene ID
GeneCard IDNone
GenAtlas ID
HGNC IDHGNC:1579
Chromosome Location5
LocusNone
References
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