Solute carrier family 2, facilitated glucose transporter member 4

NameSolute carrier family 2, facilitated glucose transporter member 4
SynonymsGlucose transporter type 4, insulin-responsive GLUT-4 GLUT4
Gene NameSLC2A4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001780|Solute carrier family 2, facilitated glucose transporter member 4
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETW
LGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAV
LGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAI
VIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPA
RKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQL
SGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGM
CGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAM
AVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQIS
AAFHRTPSLLEQEVKPSTELEYLGPDEND
Number of residues509
Molecular Weight54786.79
Theoretical pI6.94
GO Classification
Functions
    glucose transmembrane transporter activity
D-glucose transmembrane transporter activity
Processes
    hexose transport
cellular response to hypoxia
glucose transmembrane transport
carbohydrate metabolic process
response to ethanol
glucose homeostasis
amylopectin biosynthetic process
brown fat cell differentiation
glucose transport
glucose import
transmembrane transport
membrane organization
cellular response to osmotic stress
small molecule metabolic process
cellular response to insulin stimulus
Components
    trans-Golgi network transport vesicle
cytosol
T-tubule
extracellular exosome
vesicle membrane
perinuclear region of cytoplasm
external side of plasma membrane
membrane
integral component of plasma membrane
multivesicular body
plasma membrane
insulin-responsive compartment
coated pit
clathrin-coated vesicle
membrane raft
endomembrane system
General FunctionGlucose transmembrane transporter activity
Specific FunctionInsulin-regulated facilitative glucose transporter.
Transmembrane Regions25-45 82-102 112-132 143-163 172-192 202-222 288-308 324-344 354-374 385-405 418-438 446-466
GenBank Protein ID307076
UniProtKB IDP14672
UniProtKB Entry NameGTR4_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016243|Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)
ATGCCGTCGGGCTTCCAACAGATAGGCTCCGAAGATGGGGAACCCCCTCAGCAGCGAGTG
ACTGGGACCCTGGTCCTTGCTGTGTTCTCTGCGGTGCTTGGCTCCCTGCAGTTTGGGTAC
AACATTGGGGTCATCAATGCCCCTCAGAAGGTGATTGAACAGAGCTACAATGAGACGTGG
CTGGGGAGGCAGGGGCCTGAGGGACCCAGCTCCATCCCTCCAGGCACCCTCACCACCCTC
TGGGCCCTCTCCGTGGCCATCTTTTCCGTGGGCGGCATGATTTCCTCCTTCCTCATTGGT
ATCATCTCTCAGTGGCTTGGAAGGAAAAGGGCCATGCTGGTCAACAATGTCCTGGCGGTG
CTGGGGGGCAGCCTCATGGGCCTGGCCAATGCTGCTGCCTCCTATGAAATGCTCATCCTT
GGACGATTCCTCATTGGCGCCTACTCAGGGCTGACATCAGGGCTGGTGCCCATGTACGTG
GGGGAGATTGCTCCCACTCACCTGCGGGGCGCCCTGGGGACGCTCAACCAACTGGCCATT
GTTATCGGCATTCTGATCGCCCAGGTGCTGGGCTTGGAGTCCCTCCTGGGCACTGCCAGC
CTGTGGCCACTGCTCCTGGGCCTCACAGTGCTACCTGCCCTCCTGCAGCTGGTCCTGCTG
CCCTTCTGTCCCGAGAGCCCCCGCTACCTCTACATCATCCAGAATCTCGAGGGGCCTGCC
AGAAAGAGTCTGAAGCGCCTGACAGGCTGGGCCGATGTTTCTGGAGTGCTGGCTGAGCTG
AAGGATGAGAAGCGGAAGCTGGAGCGTGAGCGGCCACTGTCCCTGCTCCAGCTCCTGGGC
AGCCGTACCCACCGGCAGCCCCTGATCATTGCGGTCGTGCTGCAGCTGAGCCAGCAGCTC
TCTGGCATCAATGCTGTTTTCTATTATTCGACCAGCATCTTCGAGACAGCAGGGGTAGGC
CAGCCTGCCTATGCCACCATAGGAGCTGGTGTGGTCAACACAGTCTTCACCTTGGTCTCG
GTGTTGTTGGTGGAGCGGGCGGGGCGCCGGACGCTCCATCTCCTGGGCCTGGCGGGCATG
TGTGGCTGTGCCATCCTGATGACTGTGGCTCTGCTCCTGCTGGAGCGAGTTCCAGCCATG
AGCTACGTCTCCATTGTGGCCATCTTTGGCTTCGTGGCATTTTTTGAGATTGGCCCTGGC
CCCATTCCTTGGTTCATCGTGGCCGAGCTCTTCAGCCAGGGACCCCGCCCGGCAGCCATG
GCTGTGGCTGGTTTCTCCAACTGGACGAGCAACTTCATCATTGGCATGGGTTTCCAGTAT
GTTGCGGAGGCTATGGGGCCCTACGTCTTCCTTCTATTTGCGGTCCTCCTGCTGGGCTTC
TTCATCTTCACCTTCTTAAGAGTACCTGAAACTCGAGGCCGGACGTTTGACCAGATCTCA
GCTGCCTTCCACCGGACACCCTCTCTTTTAGAGCAGGAGGTGAAACCCAGCACAGAACTT
GAGTATTTAGGGCCAGATGAGAACGACTGA
GenBank Gene IDM20747
GeneCard IDNone
GenAtlas IDSLC2A4
HGNC IDHGNC:11009
Chromosome Location17
Locus17p13
References
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  2. Choi WH, O'Rahilly S, Buse JB, Rees A, Morgan R, Flier JS, Moller DE: Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. Diabetes. 1991 Dec;40(12):1712-8.[1756912 ]
  3. Fukumoto H, Kayano T, Buse JB, Edwards Y, Pilch PF, Bell GI, Seino S: Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. J Biol Chem. 1989 May 15;264(14):7776-9.[2656669 ]
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  6. Chiaramonte R, Martini R, Taramelli R, Comi P: Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter. Gene. 1993 Aug 25;130(2):307-8.[7916714 ]
  7. Verhey KJ, Birnbaum MJ: A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts. J Biol Chem. 1994 Jan 28;269(4):2353-6.[8300557 ]
  8. Lalioti VS, Vergarajauregui S, Pulido D, Sandoval IV: The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1. J Biol Chem. 2002 May 31;277(22):19783-91. Epub 2002 Feb 12.[11842083 ]
  9. Lisinski I, Matsumoto H, Yver DR, Schurmann A, Cushman SW, Al-Hasani H: Identification and characterization of p49/STRAP as a novel GLUT4-binding protein. Biochem Biophys Res Commun. 2006 Jun 16;344(4):1179-85. Epub 2006 Apr 21.[16647043 ]
  10. Jeyaraj S, Boehmer C, Lang F, Palmada M: Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4. Biochem Biophys Res Commun. 2007 May 11;356(3):629-35. Epub 2007 Mar 12.[17382906 ]
  11. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.[18669648 ]
  12. Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat Biotechnol. 2009 Apr;27(4):378-86. doi: 10.1038/nbt.1532. Epub 2009 Apr 6.[19349973 ]
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  14. O'Rahilly S, Krook A, Morgan R, Rees A, Flier JS, Moller DE: Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population. Diabetologia. 1992 May;35(5):486-9.[1521731 ]

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