Metalloproteinase inhibitor 2
Name | Metalloproteinase inhibitor 2 |
---|---|
Synonyms | CSC-21K TIMP-2 Tissue inhibitor of metalloproteinases 2 |
Gene Name | TIMP2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0019753|Metalloproteinase inhibitor 2 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND IYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDG KMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTE KNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP |
Number of residues | 220 |
Molecular Weight | 24398.995 |
Theoretical pI | None |
GO Classification |
Functions
enzyme activator activity metal ion binding protease binding metalloendopeptidase inhibitor activity Processes
response to hormone extracellular matrix disassembly positive regulation of MAPK cascade extracellular matrix organization negative regulation of cell proliferation cellular response to organic substance response to drug positive regulation of adenylate cyclase activity central nervous system development negative regulation of Ras protein signal transduction positive regulation of neuron differentiation negative regulation of membrane protein ectodomain proteolysis negative regulation of mitotic cell cycle regulation of Rap protein signal transduction aging negative regulation of metalloenzyme activity response to cytokine Components
extracellular exosome proteinaceous extracellular matrix extracellular region extracellular space growth cone neuronal cell body cell surface basement membrane |
General Function | Protease binding |
Specific Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. |
Transmembrane Regions | |
GenBank Protein ID | |
UniProtKB ID | P16035 |
UniProtKB Entry Name | TIMP2_HUMAN |
Cellular Location | Secreted |
Gene sequence | >lcl|BSEQ0019754|Metalloproteinase inhibitor 2 (TIMP2) ATGGGCGCCGCGGCCCGCACCCTGCGGCTGGCGCTCGGCCTCCTGCTGCTGGCGACGCTG CTTCGCCCGGCCGACGCCTGCAGCTGCTCCCCGGTGCACCCGCAACAGGCGTTTTGCAAT GCAGATGTAGTGATCAGGGCCAAAGCGGTCAGTGAGAAGGAAGTGGACTCTGGAAACGAC ATTTATGGCAACCCTATCAAGAGGATCCAGTATGAGATCAAGCAGATAAAGATGTTCAAA GGGCCTGAGAAGGATATAGAGTTTATCTACACGGCCCCCTCCTCGGCAGTGTGTGGGGTC TCGCTGGACGTTGGAGGAAAGAAGGAATATCTCATTGCAGGAAAGGCCGAGGGGGACGGC AAGATGCACATCACCCTCTGTGACTTCATCGTGCCCTGGGACACCCTGAGCACCACCCAG AAGAAGAGCCTGAACCACAGGTACCAGATGGGCTGCGAGTGCAAGATCACGCGCTGCCCC ATGATCCCGTGCTACATCTCCTCCCCGGACGAGTGCCTCTGGATGGACTGGGTCACAGAG AAGAACATCAACGGGCACCAGGCCAAGTTCTTCGCCTGCATCAAGAGAAGTGACGGCTCC TGTGCGTGGTACCGCGGCGCGGCGCCCCCCAAGCAGGAGTTTCTCGACATCGAGGACCCA TAA |
GenBank Gene ID | |
GeneCard ID | None |
GenAtlas ID | |
HGNC ID | HGNC:11821 |
Chromosome Location | 17 |
Locus | None |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Chlorothalonil |
265.902 |
||
Niclosamide |
327.117 |
||
Captafol |
349.047 |
||
Propoxur |
209.245 |