Methylated-DNA--protein-cysteine methyltransferase
Name | Methylated-DNA--protein-cysteine methyltransferase |
---|---|
Synonyms | 2.1.1.63 6-O-methylguanine-DNA methyltransferase MGMT O-6-methylguanine-DNA-alkyltransferase |
Gene Name | MGMT |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0010800|Methylated-DNA--protein-cysteine methyltransferase MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG LGGSSGLAGAWLKGAGATSGSPPAGRN |
Number of residues | 207 |
Molecular Weight | 21645.83 |
Theoretical pI | 8.23 |
GO Classification |
Functions
methylated-DNA-[protein]-cysteine S-methyltransferase activity DNA-methyltransferase activity damaged DNA binding methyltransferase activity calcium ion binding DNA binding Processes
cellular response to ionizing radiation DNA dealkylation involved in DNA repair cellular response to oxidative stress positive regulation of DNA repair response to toxic substance regulation of cysteine-type endopeptidase activity involved in apoptotic process DNA ligation response to ethanol mammary gland epithelial cell differentiation response to drug response to folic acid DNA repair negative regulation of cell death DNA methylation cellular response to organic cyclic compound Components
nucleoplasm membrane nucleus |
General Function | Methyltransferase activity |
Specific Function | Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |
Transmembrane Regions | |
GenBank Protein ID | 34559 |
UniProtKB ID | P16455 |
UniProtKB Entry Name | MGMT_HUMAN |
Cellular Location | Nucleus |
Gene sequence | >lcl|BSEQ0002276|624 bp ATGGACAAGGATTGTGAAATGAAACGCACCACACTGGACAGCCCTTTGGGGAAGCTGGAG CTGTCTGGTTGTGAGCAGGGTCTGCACGAAATAAAGCTCCTGGGCAAGGGGACGTCTGCA GCTGATGCCGTGGAGGTCCCAGCCCCCGCTGCGGTTCTCGGAGGTCCGGAGCCCCTGATG CAGTGCACAGCCTGGCTGAATGCCTATTTCCACCAGCCCGAGGCTATCGAAGAGTTCCCC GTGCCGGCACTTCACCATCCCGTTTTCCAGCAAGAGTCGTTCACCAGACAGGTGTTATGG AAGCTGCTGAAGGTTGTGAAATTCGGAGAAGTGATTTCTTACCAGCAATTAGCAGCCCTG GCAGGCAACCCCAAAGCCGCGCGAGCAGTGGGAGGAGCAATGAGAGGCAATCCTGTCCCC ATCCTCATCCCGTGCCACAGAGTGGTCTGCAGCAGCGGAGCCGTGGGCAACTACTCCGGA GGACTGGCCGTGAAGGAATGGCTTCTGGCCCATGAAGGCCACCGGTTGGGGAAGCCAGGC TTGGGAGGGAGCTCAGGTCTGGCAGGGGCCTGGCTCAAGGGAGCGGGAGCTACCTCGGGC TCCCCGCCTGCTGGCCGAAACTGA |
GenBank Gene ID | X54228 |
GeneCard ID | None |
GenAtlas ID | MGMT |
HGNC ID | HGNC:7059 |
Chromosome Location | None |
Locus | 10q26 |
References |
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Related FRC
FRCD ID | Name | Exact Mass | Structure |
---|---|---|---|
Zinc |
65.38 |
||
L-Cysteine |
121.154 |
||
1,2-Dibromoethane |
187.862 |